Helicobakter Pylori Enfeksiyonu ve Arteriyel Sertlik Arasındaki İlişki

Yıl 2021, , 151 - 156, 30.11.2021

Fatma Kaplan Efe , Aysun Aybal Kutlugün , Müjgan Tek , Gülçin Güler Şimşek , Oktay Bulur , Mustafa Çağrı Ergün , Betül Ergün

https://doi.org/10.33716/bmedj.1004137

Öz

Öz
Amaç: Çalışmalar, Helicobacter Pylori (Hp) seropozitifliğinin kardiyovasküler hastalıklar ile ilişkisini bulmuş ve Hp enfeksiyonu sırasında kronik inflamasyonun erken evre ateroskleroza neden olduğu gösterilmiştir. Bu çalışmanın amacı, endoskopik mide biyopsisi ile saptanan Hp pozitifliği ile ateroskleroz arasındaki ilişkiyi değerlendirmektir.
Gereç ve Yöntemler: Bu kesitsel çalışmada, hastalar endoskopik mide biyopsi bulgularına göre Hp pozitif (n=48) ve Hp negatif (n=61) olmak üzere 2 gruba ayrılmıştır. Tüm hastalarda augmentasyon indeksi, arteriyel sertlik ve santral kan basıncı Nabız dalga hızı analizi/Ambulatuvar kan basıncı izlemi kullanılarak ölçüldü.
Bulgular: Helicobacter Pylori pozitif grupta augmentasyon indeksi anlamlı olarak daha yüksekti (p=0.020). Santral kan basıncı ve augmentasyon indeksi ile Hp kolonizasyonunun yoğunluğu arasında hiçbir korelasyon yoktu (p=0.070, r=0.263). Ancak yapılan lojistik regresyon analizine göre yaş, BMI, sistolik ve diyastolik kan basıncı, merkezi kan basıncı, glikoz, kreatinin, toplam kolesterol, C-reaktif protein ve pozitif Hp faktörleri arasında pozitif Hp’nin 24.9 üzerinde augmentasyon indeksini tek ön gördürücü faktör olduğu belirlendi (OR: 3.593, 95%CI: 1.341-9,629, p=0.011).
Sonuç: Helicobacter Pylori pozitif saptanan hastalarda ateroskleroz ve arteriyel sertlik riski artmıştır. Ek olarak Hp pozitifliğinin arteryel sertlik için ön gördürücü olduğu izlenmiştir. Hp ile ateroskleroz ilişkinin mekanizmasını detaylandırmak için daha büyük örneklem büyüklüğünde uzun vadeli takip çalışmalarına ihtiyaç vardır.

Anahtar Kelimeler

Helicobacter Pylori, Damar Sertliği, Arterioskleroz, Nabız Dalga Analizi

The Relationship Between Arterial Stiffness and Helicobacter Pylori Infection

Öz

Abstract
Aim:Studies have found the association of Helicobacter Pylori (Hp) seropositivity with cardiovascular diseases and it has been shown that chronic inflammation with Hp may be related to early atherosclerosis. The aim of this study is to evaluate the relationship between Hp positivity detected by endoscopic gastric biopsy and arterial stiffness.
Material and Method: In this cross-sectional study, patients were divided into 2 groups as Hp positive (n=48) and Hp negative (n=61) according to endoscopic gastric biopsy findings. Augmentation index, arterial stiffness and central blood pressure were measured using Pulse wave velocity analysis/Ambulatory blood pressure monitoring in all patients.
Results: Augmentation index was significantly higher in the Hp positive group (p=0.020). There was no correlation between central blood pressure and augmentation index and the intensity of Hp colonization (p=0.070, r=0.263). However, logistic regression analysis revealed that positive Hp (OR: 3.593, 95%CI: 1.341-9,629, p=0.011) was the only variable predictive for an augmentation index > 24.9 among variables including, age, BMI, systolic and diastolic blood pressure, central blood pressure, glucose, creatinine, total cholesterol, C-reactive protein, and positive Hp.
Conclusion: Helicobacter Pylori positive patients with confirmed biopsy have an increased arterial stiffness. Moreover, presence of Hp infection is predictive for an increased arterial stiffness. Regarding the diversity and frequency of Hp worldwide long term follow up studies with larger sample size are needed to elaborate the mechanism of this relationship.

Anahtar Kelimeler

Helicobacter Pylori, Vascular Stiffness, Arteriosclerosis, Pulse Wave Analysis

Kaynakça

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