Sertoli Leyding Cell Ovarian Tumor in a Patient with Hirsutism

Öz

Hyperandrogenism is a condition of androgen excess that causes symptoms such as hirsutism, acne and alopecia in women. Hirsutism is the increase of male pattern hair growth in androgen sensitive areas in women. There are many causes of hyperandrogenism. Androgen-secreting ovarian and adrenal tumors are among the rare causes of hyperandrogenism. Ovarian or adrenal-induced tumors should be considered especially in cases where the clinical picture progresses rapidly and the levels of androgen accompanied by virilization are very high. A rare cause of hyperandrogenism after bilateral oophorectomy was diagnosed with sertoli leyding cell ovarian tumor in a postmenopausal female patient with isolated total testosterone level of 4.15 ng / mL and no lesion was detected on imaging.

Anahtar Kelimeler

• Hirsutism,testosterone,ovarian tumor,postmenopausal

Hirsutizmli Hastada Sertoli Leyding Hücreli Over Tümörü

Öz

Hiperandrojenizm; kadınlarda hirsutizm, akne, alopesi gibi belirtilere neden olan androjen fazlalığı durumudur. Hirsutizm ise kadınlarda androjene duyarlı bölgelerde erkek tipi kıllanma artışıdır. Hiperandrojenizmin birçok nedeni bulunmaktadır. Androjen salgılayan over ve adrenal tümörler hiperandrojenizmin nadir görülen nedenlerindendir. Özellikle klinik tablonun hızlı ilerlediği, virilizasyon bulgularının eşlik ettiği androjen düzeylerinin çok yüksek olduğu olgularda over ya da adrenal kaynaklı tümörler akla gelmelidir. İzole total testosteron düzeyi 4,15 ng/mL olan ve görüntülemede lezyon saptanmayan postmenopozal kadın hastada bilateral ooforektomi sonrası hiperandrojenizmin nadir bir nedeni sertoli leyding hücreli over tümör tanısı konuldu.

Anahtar Kelimeler

• Hirsutizim,testosteron,over tümörü,postmenopozal

Kaynakça

1. 1. Markovski M, Hall J, Jin M, Laubscher T, Regier L. Approach to the management of idiopathic hirsutism. Can Fam Physician 2012;58;173–7.
2. 2. Blume U. An overview of unwanted female hair. Br J Dermatol 2011;165;19–23.
3. 3. Escobar HF. Diagnosis and management of hirsutism. Ann N Y Acad Sci 2010;1205:166–74.
4. 4. Castelo C, Cancelo MJ Comprehensive clinical management of hirsutism. Gynecol Endocrinol 2010;26:484–93.
5. 5. Paparodis R, Dunaif A. The Hirsute woman: challenges in evaluation and management. Endocr Pract 2011;17:807–18.
6. 6. Robert B. Diagnosis and treatment of hirsutism. Hospital Practice 1973;3; 91-98.
7. 7. Kirschner M. Hirsutism and virilism in women. Special topics in endocrinology and metabolism 1984: 55-93.