Öz

Aim: Intraabdominal adhesions continue being a major problem of general surgery, there is no consensus for the treatment. Our aim in this study was to asses and compare the effects of Seprafilm which is often studied with Mesofol which to the best of our knowledge has not been studied in intraabdominal adhesions and Taurolin for which there exists no consensus. Materials and Methods: Thirty male Wistar albino rats were divided into 5 groups. After cecal abrasion; in group;1 no intervention was made (sham), in group 2; 2 ml of saline, in group 3; 2 ml Taurolin %2 was added, in group 4; 2x2 cm Mesofol was inserted beneath the abdominal wall, in group 5; 2x2 cm of Seprafilm was inserted beneath the abdominal wall, Adhesions were evaluated using three different classification systems. Nair classification, grading according to the severity of adhesions classification, and grading according to the affected area classification. Results: Mesofol and Seprafilm were both effective in decreasing intraabdominal adhesions in all classification systems. There is no statistical difference between Mesofol and Seprafilm. Conclusion: Statistically significance in decreasing intra-abdominal adhesions was obtained with both Mesofol and Seprafilm. While Mesofol can be proposed as an agent to degrease intraabdominal adhesions more studies are required

Anahtar Kelimeler

• Intra-abdominal adhesions
• Seprafilm
• Mesofol
• Taurolin

Ameliyat sonrası karın içi yapışıklıkların önlenmesinde Taurolin, Seprafilm ve Mesofolun etkinliklerinin karşılaştırlması

Öz

Amaç: Yapışıklık hala genel cerrahinin önemli sorunlarından biri olmaya devam etmekte olup; tedavide fikir birliği oluşmamıştır. Çalışmanın amacı daha önce pek çok çalışmada kullanılan Seprafilm ile bağırsak yapışıklığı konusunda bildiğimiz kadarı ile kullanılmayan Mezofolün ve hakkında farklı görüşler bulunan Taurolidin etkinliklerini araştırmak ve karşılaştırmaktır. Gereç ve Yöntemler: Otuz adet Wistar-Albino erkek sıçan kullanılarak 5 grup oluşturuldu. Çekal abrasyon sonrası grup 1’de ek işlem yapılmadan karın kapatıldı (sham), grup 2’de karın içerisine 2 ml serum fizyolojik verildi, grup 3’te karın içerisine 2 ml Taurolidin %2 verildi, grup 4’e karın duvarı altına 2x2 cm’lik Mesofol uygulandı, grup 5’te karın duvarı altına 2x2 cm’lik Seprafilm uygulandı. Yapışıklıklar; Nair sınıflaması, yapışıklıkların şiddetine göre derecelendirme, tulan alanın yaygınlığına göre tanımlanmış derecelendirme sistemleri olmak üzere üç farklı derecelendirme sistemi kullanılarak değerlendirilmiştir. Bulgular: Tüm sınıflama sistemlerine göre Mesofol ve Seprafilm karın içi yapışıklıkları önlemede etkili bulunmuştur. Seprafilm ile Mesofol arasında istatistiki olarak anlamlı bir fark yoktur. Sonuç: Mesofol ve Seprafilm kullanımı ile karın içi yapışıklıklarda istatistiki olarak anlamlı azalma tespit edilmiştir. Mesofolün karın içi yapışıklıkların önlenmesi amacı ile kullanılabilecek bir ajan olduğunu düşündürmekle birlikte; daha çok çalışma yapılması gerekmektedir.

Anahtar Kelimeler

• karın içi yapışıklık
• Seprafilm
• Mesofol
• Taurolin

Kaynakça

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