Rarely seen autoimmune polyglandular syndrome; Type 3B complicated with celiac disease

Year 2018, Volume: 2 Issue: 1, 1 - 8, 11.02.2018

Hakan Aydın Zülfükar Bilge Abdullah Algın Hüseyin Avni Fındıklı Bünyamin Aydın

Abstract

Autoimmune
polyglandular syndrome (APS) is a combination of different autoimmune diseases.
APS type 3 is defined by the presence of autoimmune thyroid disease (ATD)
without Addison’s disease and at least one autoimmune disease such as type 1
diabetes mellitus (type 3A), chronic atrophic gastritis, pernicious
anemia,autoimmune hepatitis or celiac disease (type 3B), vitiligo, alopecia, myasthenia
gravis (type 3C), autoimmune rheumatic disorders, vasculitis (type 3D). Celiac
disease (CD) is an immune-mediated disease with a strong genetic influence.
Type 1 diabetes mellitus (T1DM) and ATD are well established and people
suffering from these two diseases are considered at high risk of developing CD.
Here we present a rarely seen case of a 32-year-old woman with  T1 DM and ATD complicated with CD, which is
defined APS type 3B.

Keywords

Autoimmune polyglandular syndrome, Celiac disease, Type 1 diabetes mellitus, Autoimmune thyroid disease

Çölyak hastalığı ile komplike nadir görülen otoimmün poliglandüler sendrom; tip3B

Abstract

Otoimmün poliglandüler
sendrom (OPS) farklı otoimmün hastalıkların kombinasyonudur. Klinik kriterler
baz alınarak OPS'nin dört ana tipi tariflenmiştir.Tip 3 formu; Addison
hastalığı olmadan, otoimmün tiroid hastalıklarından birine Tip 1 diabetes mellitus
(Tip 3A) veya kronik atrofik gastrit, pernisiyöz anemi, çölyak hastalığı,
otoimmün hepatit (Tip 3B), vitiligo,alopesi,myastenia graves (Tip 3C), kollajen
hastalıklar, vaskülit (Tip 3D) gibi otoimmün hastalıkların eşlik ettiği
sendromdur. Çölyak hastalığı (CD), güçlü bir genetik etkiye sahip immün aracılı
bir hastalıktır. Tip 1 diabetes mellitus (T1DM) ve OTH, insanların bu
hastalıklardan etkilendiği ve Çölyak hastalığı gelişimi için yüksek risk
taşıyan iyi tanımlanmış iki hastalıktır. Burada T1DM ve OTH tanıları ile
beraber Çölyak hastalığı ile komplike olmuş 32 yaşında kadın bir hastayı yani
OPS Tip 3B sendromunu sunmaktayız.

Keywords

Otoimmün poliglandüler sendrom, Çölyak hastalığı, Tip 1 diabetes mellitus, Otoimmün tiroid hastalığı

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