EVALUATION OF RELATIONSHIP BETWEEN PAIN SCORE AND SERUM VITAMIN B12 AND FOLATE LEVELS IN FIBROMYALGIA PATIENTS

Yıl 2018, Cilt: 2 Sayı: 1, 51 - 59, 11.02.2018

Serdar Hıra , Hatice Gülşah Karataş İsmail Haskul Ramazan Gündüz Betül Üstün Müfit Akyüz

Öz

Aim: Fibromyalgia syndrome
(FMS) is a common rheumatologic disorder which is characterized by chronic
widespread musculoskeletal pain and several additional symptoms including
morning stiffness, fatigue, sleep disorder, low pain threshold, cognitive dysfunction,
anxiety and depressive episodes. Folate and vitamin B12 are two metabolically
and clinically related vitamins that share some important functions related to
the one-carbon metabolism and related diseases. Studies have revealed that
vitamin B12 and folate are associated with pain and pain-related disorders. The
aim of this study was to compare serum vitamin B12 and folate levels between
FMS patient group and the control group and to present a new evidence of
pathogenesis FMS disease.

Material and Methods: 46 female FMS outpatients and 46 healthy
individuals were enrolled in the study. Clinical information and biochemical
markers including vitamin B12, folate, erythrocyte sedimentation rate (ESR) and
C-reactive protein (CRP) and visual analogue scale (VAS) scores were obtained
from the patients’ medical files.

Results: There were no significant differences in vitamin B12, folate
and ESR levels between the two groups (p >0.05). Serum CRP levels was
significantly increased in FMS group (p =0.027). There was no correlation
between VAS scores and biochemical markers in patients group.

Conclusions: The results of this study have indicated that vitamin B12
and folate levels are not involved in the pathogenesis of FMS. No relevant
correlations between the perception of pain and one carbon metabolism
biomarkers were observed in FMS patients.

Anahtar Kelimeler

Fibromyalgia, Vitamin B12, Folate, One carbon metabolism, Pain

FİBROMİYALJİ HASTALARINDA VİTAMİN B12 VE FOLAT DÜZEYLERİ İLE AĞRI SKORLARI ARASINDAKİ İLİŞKİNİN İNCELENMESİ

Öz

Amaç: Fibromiyalji sendromu (FMS),
yaygın kas iskelet sistemi ağrısı ile sabah sertliği, yorgunluk, uyku
bozukluğu, düşük ağrı eşiği, bilişsel işlev bozukluğu, anksiyete ve depresif
ataklar gibi ilave semptomlar ile karakterize, yaygın bir romatolojik
bozukluktur. Folat ve B12 vitamini, tek karbon metabolizması ve ilişkili
hastalıklarla ilgili önemli işlevleri paylaşan metabolik ve klinik olarak
birbirleri ile ilişkili vitaminlerdir. Yapılan çalışmalarda, folat ve B12
vitamininin ağrı ve ağrıya bağlı rahatsızlıklarla ilişkili olduğu
gösterilmiştir. Bu çalışmada, FMS hasta grubu ile kontrol grubu arasındaki
serum vitamin B12 ve folat düzeylerini karşılaştırmak ve FMS hastalık
patogenezine yeni kanıtlar sunmayı amaçlamaktayız.

Gereç ve Yöntem: Çalışmaya 46
kadın FMS hastası ve 46 sağlıklı birey alındı. Hastaların dosyalarından B12
vitamini, folat, eritrosit sedimantasyon hızı (ESR) ve C-reaktif protein (CRP)
ve görsel analog skalası (VAS) skorları dahil olmak üzere klinik bilgi ve
biyokimyasal belirteçler elde edildi.

Bulgular: İki grup arasında
vitamin B12, folat ve ESR düzeylerinde anlamlı farklılık olmadığı bulundu (p>
0.05). Serum CRP düzeyleri, FMS grubunda anlamlı olarak arttığı gözlendi (p =
0.027). Hasta grubunda, VAS skorları ile biyokimyasal belirteçler arasında
korelasyon olmadığı gözlendi.

Sonuç: Bu çalışma, B12
vitamini ve folat düzeylerinin FMS patogenezinde yer almadığını göstermiştir.
FMS hastalarında ağrı algılaması ile tek karbon metabolizma belirteçleri
arasında korelasyon gözlenmemiştir.

Anahtar Kelimeler

Vitamin B12, Fibromiyalji, Folat, Tek karbon metabolizması, Ağrı

Kaynakça

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