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Mikrobiyata ve Kök Hücre ile Kemik İlişkisi Birlikteliği

Year 2020, Volume: 4 Issue: 1, 26 - 31, 09.03.2020
https://doi.org/10.33716/bmedj.653421

Abstract

Mikrobiyota, deneysel verileri son zamanlarda artan ve klinik uygulamaları olacak şekilde gelişen, bir ürün olma potansiyelindedir. Etkilerini özellikle kök hücre olmak üzere hücre davranışını değiştirerek göstermektedir. Patolojide olan bu değişikliğin anlaşılması, tedavide kullanılmalarının önünü açmaktadır. Barsak mikrobiyotasının en önemli etki gösterdiği ve yaşam kalitesini olumsuz etkileyen hastalıkların başında kemik ile ilgili patolojiler gelmektedir. Bu derlemede mikrobiyota ile kemik ilişkisinin detayları literatürdeki kaynaklar kullanılarak açıklandı. Son yılların mikrobiyota ve kemik ile ilişkili makaleleri incelenerek önemli görülen bilgiler birleştirildi. Barsak mikrobiyotası değişik etkenlere maruz kaldığında, hücrelerin kendileri ve salgıladıkları faktörler de değişerek hemostazın bozulmasına neden olmaktadır. Özellikle biyoinformatik veriler üzerinden alınan bilgilerin deneysel verilerle birleşmesi, mikrobiyatanın kemik patolojilerinde tedavi amaçlı kullanılabileceklerini göstermektedir. Gelişen teknoloji, mikrobiyata gibi maliyetleri düşük, tedavi etkinliği yüksek klinik kullanımı olabilecek ürünlerin oluşmasını sağlayacaktır. Üç boyutlu organoid modelinde olduğu gibi çok daha kolay incelenip ve anlaşılabilecek mikrobiyota etkisi yine kolaylıkla aynı modelle tedavinin etkinliğinde gösterebilecektir. Bunların sonucu olarak yaşam kalitesi düşmüş hastalara yeni umutlar sunabilecektir.

References

  • 1. Tan Y, Wei Z, Chen J, An J, Li M, Zhou L, Men Y, Zhao S. Save your gut save your age: The role of the microbiome in stem cell ageing. J Cell Mol Med. 2019 Jun 17. doi: 10.1111/jcmm.14373. [Epub ahead of print] Review. PubMed PMID: 31207055.
  • 2. Qin Y, Wade PA. Crosstalk between the microbiome and epigenome: messages from bugs. J Biochem. 2018 Feb 1;163(2):105-112.
  • 3. Peck BCE, Shanahan MT, Singh AP, Sethupathy P. Gut Microbial Influences on the Mammalian Intestinal Stem Cell Niche. Stem Cells Int. 2017; 2017:5604727doi: 10.1155/2017/5604727. Epub 2017 Aug 22. Review. PubMed PMID: 28904533; PubMed Central PMCID: PMC5585682.
  • 4. Hou Q, Ye L, Huang L, Yu Q. The Research Progress on Intestinal Stem Cells and Its Relationship with Intestinal Microbiota. Front Immunol. 2017 May 23; 8:599. doi: 10.3389/fimmu.2017.00599. eCollection 2017. Review. PubMed PMID: 28588586; PubMed Central PMCID: PMC5440531.
  • 5. Xiao E, He L, Wu Q, Li J, He Y, Zhao L, Chen S, An J, Liu Y, Chen C, Zhang Y. Microbiota regulates bone marrow mesenchymal stem cell lineage differentiation and immunomodulation. Stem Cell Res Ther. 2017 Sep 29;8(1):213. doi: 10.1186/s13287-017-0670-7. PubMed PMID: 28962644; PubMed Central PMCID: PMC5622543.
  • 6. Hsu E, Pacifici R. From Osteoimmunology to Osteomicrobiology: How the Microbiota and the Immune System Regulate Bone. Calcif Tissue Int. 2018 May;102(5):512-521. doi: 10.1007/s00223-017-0321-0. Epub 2017 Oct 10. Review. PubMed PMID: 29018933; PubMed Central PMCID: PMC5893441.
  • 7- Eggert FM, Levin L. Biology of teeth and implants: Host factors - pathology, regeneration, and the role of stem cells. Quintessence Int. 2018;49(6):497-509. doi: 10.3290/j.qi.a40289. Review. PubMed PMID: 29756133
  • 8. Stedman A, Nigro G, Sansonetti PJ. [Microbiota-intestinal stem cells dialog: a key element for intestinal regeneration]. Med Sci (Paris). 2016 Nov;32(11):983-990. doi: 10.1051/medsci/20163211014. Epub 2016 Dec 23. Review. French. PubMed PMID: 28008839.
  • 9. Bloemendaal AL, Buchs NC, George BD, Guy RJ. Intestinal stem cells and intestinal homeostasis in health and in inflammation: A review. Surgery. 2016 May;159(5):1237-48. doi: 10.1016/j.surg.2016.01.014. Epub 2016 Feb 28. Review. PubMed PMID: 26936524.
  • 10. Bonfini A, Liu X, Buchon N. From pathogens to microbiota: How Drosophila intestinal stem cells react to gut microbes. Dev Comp Immunol. 2016 Nov; 64:22-38. doi: 10.1016/j.dci.2016.02.008. Epub 2016 Feb 6. Review. PubMed PMID: 26855015
  • 11. Dutta D, Heo I, Clevers H. Disease Modeling in Stem Cell-Derived 3D Organoid Systems. Trends Mol Med. 2017 May;23(5):393-410. doi: 10.1016/j.molmed.2017.02.007. Epub 2017 Mar 21. Review. PubMed PMID: 28341301.
  • 12. Cowardin CA, Ahern PP, Kung VL, Hibberd MC, Cheng J, Guruge JL, Sundaresan V Head RD, Barile D, Mills DA, Barratt MJ, Huq S, Ahmed T, Gordon JI. Mechanisms by which sialylated milk oligosaccharides impact bone biology in a gnotobiotic Mouse model of infant undernutrition. Proc Natl Acad Sci U S A. 2019 Jun 11;116(24):11988-11996. doi: 10.1073/pnas.1821770116. Epub 2019 May 28. PubMed PMID: 31138692; PubMed Central PMCID: PMC6575181.
  • 13. Zhao X, Ai J, Mao H, Gao X. Effects of Eclipta prostrata on gut microbiota of SAMP6 mice with osteoporosis. J Med Microbiol. 2019 Mar;68(3):402-416. doi: 10.1099/jmm.0.000936. Epub 2019 Feb 8. PubMed PMID: 30735116.
  • 14. Schepper JD, Collins FL, Rios-Arce ND, Raehtz S, Schaefer L, Gardinier JD, Britton RA, Parameswaran N, McCabe LR. Probiotic Lactobacillus reuteri Prevents Postantibiotic Bone Loss by Reducing Intestinal Dysbiosis and Preventing Barrier Disruption. J Bone Miner Res. 2019 Apr;34(4):681-698. doi: 10.1002/jbmr.3635. Epub 2019 Jan 28. PubMed PMID: 30690795; PubMed Central PMCID: PMC6557403.
  • 15. Nath A, Molnár MA, Csighy A, Kőszegi K, Galambos I, Huszár KP, Koris A, Vatai G. Biological Activities of Lactose-Based Prebiotics and Symbiosis with Probiotics on Controlling Osteoporosis, Blood-Lipid and Glucose Levels. Medicina (Kaunas). 2018 Dec 3;54(6). pii: E98. doi: 10.3390/medicina54060098. Review. PubMed PMID: 30513975; PubMed Central PMCID: PMC6306850.
  • 16. Uchida Y, Irie K, Fukuhara D, Kataoka K, Hattori T, Ono M, Ekuni D, Kubota S, Morita M. Commensal Microbiota Enhance Both Osteoclast and Osteoblast Activities. Molecules. 2018 Jun 23;23(7). pii: E1517. doi: 10.3390/molecules23071517. PubMed PMID: 29937485; PubMed Central PMCID: PMC6100304.
  • 17. KA, Huang E, Westwater C, Kirkwood KL. Commensal Gut Microbiota Immunomodulatory Actions in Bone Marrow and Liver have Catabolic Effects on Skeletal Homeostasis in Health. Sci Rep. 2017 Jul 18;7(1):5747. doi: 10.1038/s41598-017-06126-x. PubMed PMID: 28720797; PubMed Central PMCID: PMC5515851.
  • 18. Luo Y, Chen GL, Hannemann N, Ipseiz N, Krönke G, Bäuerle T, Munos L, Wirtz S, Schett G, Bozec A. Microbiota from Obese Mice Regulate Hematopoietic Stem Cell Differentiation by Altering the Bone Niche. Cell Metab. 2015 Nov 3;22(5):886-94. doi: 10.1016/j.cmet.2015.08.020. Epub 2015 Sep 17. PubMed PMID: 26387866.
  • 19. McCabe L, Britton RA, Parameswaran N. Prebiotic and Probiotic Regulation of Bone Health: Role of the Intestine and its Microbiome. Curr Osteoporos Rep. 2015 Dec;13(6):363-71 doi: 10.1007/s11914-015-0292-x. Review. PubMed PMID: 26419466; PubMed Central PMCID: PMC4623939.

The Relationship of Microbiota with Stem Cell and Bone

Year 2020, Volume: 4 Issue: 1, 26 - 31, 09.03.2020
https://doi.org/10.33716/bmedj.653421

Abstract

The microbiota is a potential product which experimental data and clinical applications have increased recently. The microbiota shows its effects by changing cell behaviors, particularly those of the stem cells. Understanding of these changes in pathology opens the way for their use in treatment. Changes in intestinal microbiota related to bone diseases which also have a negative impact on patient life quality. In this review, the relationship of microbiota with stem cell and bone was explained based on the literature. Microbiota and bone-related articles of the recent years were reviewed, and the information considered important was collected. When the intestinal microbiota is exposed to various factors, stem cells themselves and the factors they secrete change, which causes hemostasis to deteriorate. The combination of experimental and bioinformatics data shows the possible use of microbiota for the treatment of bone pathologies. Developing technology will make it possible to produce products with significant efficiency and low costs in clinical applications. Using three-dimensional organoid model, it will be much easier to understand the effect of microbiota and similar model can be used for the effectiveness of the treatment. As a result, it may offer new hopes to patients with reduced quality of life.

References

  • 1. Tan Y, Wei Z, Chen J, An J, Li M, Zhou L, Men Y, Zhao S. Save your gut save your age: The role of the microbiome in stem cell ageing. J Cell Mol Med. 2019 Jun 17. doi: 10.1111/jcmm.14373. [Epub ahead of print] Review. PubMed PMID: 31207055.
  • 2. Qin Y, Wade PA. Crosstalk between the microbiome and epigenome: messages from bugs. J Biochem. 2018 Feb 1;163(2):105-112.
  • 3. Peck BCE, Shanahan MT, Singh AP, Sethupathy P. Gut Microbial Influences on the Mammalian Intestinal Stem Cell Niche. Stem Cells Int. 2017; 2017:5604727doi: 10.1155/2017/5604727. Epub 2017 Aug 22. Review. PubMed PMID: 28904533; PubMed Central PMCID: PMC5585682.
  • 4. Hou Q, Ye L, Huang L, Yu Q. The Research Progress on Intestinal Stem Cells and Its Relationship with Intestinal Microbiota. Front Immunol. 2017 May 23; 8:599. doi: 10.3389/fimmu.2017.00599. eCollection 2017. Review. PubMed PMID: 28588586; PubMed Central PMCID: PMC5440531.
  • 5. Xiao E, He L, Wu Q, Li J, He Y, Zhao L, Chen S, An J, Liu Y, Chen C, Zhang Y. Microbiota regulates bone marrow mesenchymal stem cell lineage differentiation and immunomodulation. Stem Cell Res Ther. 2017 Sep 29;8(1):213. doi: 10.1186/s13287-017-0670-7. PubMed PMID: 28962644; PubMed Central PMCID: PMC5622543.
  • 6. Hsu E, Pacifici R. From Osteoimmunology to Osteomicrobiology: How the Microbiota and the Immune System Regulate Bone. Calcif Tissue Int. 2018 May;102(5):512-521. doi: 10.1007/s00223-017-0321-0. Epub 2017 Oct 10. Review. PubMed PMID: 29018933; PubMed Central PMCID: PMC5893441.
  • 7- Eggert FM, Levin L. Biology of teeth and implants: Host factors - pathology, regeneration, and the role of stem cells. Quintessence Int. 2018;49(6):497-509. doi: 10.3290/j.qi.a40289. Review. PubMed PMID: 29756133
  • 8. Stedman A, Nigro G, Sansonetti PJ. [Microbiota-intestinal stem cells dialog: a key element for intestinal regeneration]. Med Sci (Paris). 2016 Nov;32(11):983-990. doi: 10.1051/medsci/20163211014. Epub 2016 Dec 23. Review. French. PubMed PMID: 28008839.
  • 9. Bloemendaal AL, Buchs NC, George BD, Guy RJ. Intestinal stem cells and intestinal homeostasis in health and in inflammation: A review. Surgery. 2016 May;159(5):1237-48. doi: 10.1016/j.surg.2016.01.014. Epub 2016 Feb 28. Review. PubMed PMID: 26936524.
  • 10. Bonfini A, Liu X, Buchon N. From pathogens to microbiota: How Drosophila intestinal stem cells react to gut microbes. Dev Comp Immunol. 2016 Nov; 64:22-38. doi: 10.1016/j.dci.2016.02.008. Epub 2016 Feb 6. Review. PubMed PMID: 26855015
  • 11. Dutta D, Heo I, Clevers H. Disease Modeling in Stem Cell-Derived 3D Organoid Systems. Trends Mol Med. 2017 May;23(5):393-410. doi: 10.1016/j.molmed.2017.02.007. Epub 2017 Mar 21. Review. PubMed PMID: 28341301.
  • 12. Cowardin CA, Ahern PP, Kung VL, Hibberd MC, Cheng J, Guruge JL, Sundaresan V Head RD, Barile D, Mills DA, Barratt MJ, Huq S, Ahmed T, Gordon JI. Mechanisms by which sialylated milk oligosaccharides impact bone biology in a gnotobiotic Mouse model of infant undernutrition. Proc Natl Acad Sci U S A. 2019 Jun 11;116(24):11988-11996. doi: 10.1073/pnas.1821770116. Epub 2019 May 28. PubMed PMID: 31138692; PubMed Central PMCID: PMC6575181.
  • 13. Zhao X, Ai J, Mao H, Gao X. Effects of Eclipta prostrata on gut microbiota of SAMP6 mice with osteoporosis. J Med Microbiol. 2019 Mar;68(3):402-416. doi: 10.1099/jmm.0.000936. Epub 2019 Feb 8. PubMed PMID: 30735116.
  • 14. Schepper JD, Collins FL, Rios-Arce ND, Raehtz S, Schaefer L, Gardinier JD, Britton RA, Parameswaran N, McCabe LR. Probiotic Lactobacillus reuteri Prevents Postantibiotic Bone Loss by Reducing Intestinal Dysbiosis and Preventing Barrier Disruption. J Bone Miner Res. 2019 Apr;34(4):681-698. doi: 10.1002/jbmr.3635. Epub 2019 Jan 28. PubMed PMID: 30690795; PubMed Central PMCID: PMC6557403.
  • 15. Nath A, Molnár MA, Csighy A, Kőszegi K, Galambos I, Huszár KP, Koris A, Vatai G. Biological Activities of Lactose-Based Prebiotics and Symbiosis with Probiotics on Controlling Osteoporosis, Blood-Lipid and Glucose Levels. Medicina (Kaunas). 2018 Dec 3;54(6). pii: E98. doi: 10.3390/medicina54060098. Review. PubMed PMID: 30513975; PubMed Central PMCID: PMC6306850.
  • 16. Uchida Y, Irie K, Fukuhara D, Kataoka K, Hattori T, Ono M, Ekuni D, Kubota S, Morita M. Commensal Microbiota Enhance Both Osteoclast and Osteoblast Activities. Molecules. 2018 Jun 23;23(7). pii: E1517. doi: 10.3390/molecules23071517. PubMed PMID: 29937485; PubMed Central PMCID: PMC6100304.
  • 17. KA, Huang E, Westwater C, Kirkwood KL. Commensal Gut Microbiota Immunomodulatory Actions in Bone Marrow and Liver have Catabolic Effects on Skeletal Homeostasis in Health. Sci Rep. 2017 Jul 18;7(1):5747. doi: 10.1038/s41598-017-06126-x. PubMed PMID: 28720797; PubMed Central PMCID: PMC5515851.
  • 18. Luo Y, Chen GL, Hannemann N, Ipseiz N, Krönke G, Bäuerle T, Munos L, Wirtz S, Schett G, Bozec A. Microbiota from Obese Mice Regulate Hematopoietic Stem Cell Differentiation by Altering the Bone Niche. Cell Metab. 2015 Nov 3;22(5):886-94. doi: 10.1016/j.cmet.2015.08.020. Epub 2015 Sep 17. PubMed PMID: 26387866.
  • 19. McCabe L, Britton RA, Parameswaran N. Prebiotic and Probiotic Regulation of Bone Health: Role of the Intestine and its Microbiome. Curr Osteoporos Rep. 2015 Dec;13(6):363-71 doi: 10.1007/s11914-015-0292-x. Review. PubMed PMID: 26419466; PubMed Central PMCID: PMC4623939.
There are 19 citations in total.

Details

Primary Language English
Subjects Clinical Sciences
Journal Section DERLEMELER
Authors

Emine Müge Karakayalı 0000-0001-5779-4102

Mehmet Tuğlu 0000-0002-0569-8415

Publication Date March 9, 2020
Published in Issue Year 2020 Volume: 4 Issue: 1

Cite

APA Karakayalı, E. M., & Tuğlu, M. (2020). The Relationship of Microbiota with Stem Cell and Bone. Balıkesir Medical Journal, 4(1), 26-31. https://doi.org/10.33716/bmedj.653421