The Role of Preoperative Neutrophil/Lymphocyte, Lymphocyte/Monocyte and Platelet/Lymphocyte Ratios in the Serous Over Cancer Survival

Year 2021, Volume: 5 Issue: 1, 43 - 53, 28.02.2021

Serap Durmuşoğlu Erben , Fatih Kılıç , Mehmet Ünsal , Okan Aytekin Günsu Kimyon Cömert , Alper Karalök , Osman Türkmen , Ömer Lütfi Tapısız , Taner Turan , Gökhan Tulunay

https://doi.org/10.33716/bmedj.871929

Cited By: 2

Abstract

Aim: The aim of this study was to evaluate the prognostic value of the preoperative systemic inflammatory markers in patients with serous-type ovarian cancer and to reveal their relationship with survival.
Materials and Methods: Data from 86 serous type ovarian cancer patients were evaluated retrospectively. Neutrophil-lymphocyte (NLR), lymphocyte-monocyte (LMR) and platelet-lymphocyte (PLR) ratios were used as preoperative inflammatory markers. The patients were grouped as high or low risk according to NLR, LMR and PLR values. Median values were used as cut-off values for categorizing groups. The effects of NLR, LMR and PLR values on disease-free survival (DFS) and overall survival (OS) with clinical, surgical and pathological variables were investigated.
Results: The median age of the patients was 58.03 years (range; 25-80). The stage of the disease was found as 12 patients stage I-II and 74 patients stage III-IV. The median follow-up was 29.45 months (range; 1-63), during this period 21 (24.4%) patients developed recurrence and 15 (17.4%) patients died due to the disease. The mean DFS time was 46.32 ± 3.00 months and OS time was 51.30 ± 2.43 months in the whole study group. For DFS; omentum metastasis, splenic metastasis, diaphragmatic metastasis, colon metastasis, surgical outcome and adjuvant treatment success and for OS; omentum metastasis, whether the patient received adjuvant therapy and adjuvant treatment success were found to be significant (p<0.05). No statistically significant relationship was found between NLR-LMR-TLR and OS-DFS data (p>0.05).
Conclusion: It was found that preoperative inflammatory markers could not predict disease-free survival and overall survival in serous type ovarian cancer.

Keywords

Inflammatory marker, lymphocyte-monocyte ratio, neutrophil-lymphocyte ratio, platelet-lymphocyte ratio, serous ovarian cancer

Preoperatif Nötrofil/Lenfosit, Lenfosit/Monosit ve Trombosit/Lenfosit Oranlarının Seröz Over Kanseri Sağ Kalımındaki Yeri

Abstract

Amaç: Seröz tip over kanserinde preoperatif sistemik inflamatuar belirteçlerin prognozu predikte etmedeki etkinliğini değerlendirmek ve sağ kalım ile ilişkilerini tanımlamak amaçlandı.
Gereç ve Yöntemler: Çalışma grubu seröz tip over kanseri nedeniyle tedavisi yapılan 86 hastadan oluşturuldu. Hastalara ait veriler retrospektif olarak tarandı. Preoperatif inflamatuar belirteçler olarak nötrofil/lenfosit oranı (NLO), lenfosit/monosit oranı (LMO) ve trombosit/lenfosit oranları (TLO) kullanıldı. Hastalar NLO, LMO ve TLO değerlerine göre yüksek veya düşük riskli olarak gruplandırıldı. Grupları kategorize etmede sınır değer olarak ortanca değerler kullanıldı. Klinik, cerrahi ve patolojik değişkenlerle birlikte NLO, LMO, TLO değerlerinin hastalıksız sağ kalım (HSK) ve genel sağ kalım (GSK) üzerindeki etkisi incelendi.
Bulgular: Hastaların ortanca yaşları 58.03 (aralık; 25-80) yıldı. Evre 12 hastada evre I-II ve 74 hastada evre III-IV’tü. Ortanca takip süresi 29.45 aydı (aralık; 1-63) ve bu süre içerisinde 21 (%24,4) hastada rekürrens geliştiği ve 15 (%17,4) hastanın hastalıktan dolayı öldüğü tespit edildi. Tüm çalışma grubunda ortalama HSK süresi 46.32±3,00 ay ve GSK süresi 51.30±2.43 aydı. HSK için; omentum metastazı, dalak metastazı, diyafragma metastazı, kolon metastazı, cerrahi sonuç ve adjuvant tedavi başarısı, GSK için; omentum metastazı, hastanın adjuvant tedavi alıp almaması ve adjuvan tedavi başarısı anlamlıydı (p<0.05). NLO-LMO-TLO ile GSK ve HSK verileri arasında istatistiksel olarak anlamlı bir ilişki saptanmadı (p>0.05).
Sonuç: Seröz tip over kanserinde, preoperatif inflamatuar belirteçlerin hastalıksız sağ kalımı ve genel sağ kalımı öngörmede yönlendirici olmadığı tespit edilmiştir.

Keywords

İnflamatuar belirteç, Lenfosit/monosit oranı, Nötrofil/lenfosit oranı, Trombosit/lenfosit oranı, Seröz over kanseri

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