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Hastaneye başvuru sırasında elektrolit değerleri COVID-19 hastalarını nasıl etkiler?

Year 2022, Volume: 6 Issue: 1, 1 - 6, 28.02.2022
https://doi.org/10.33716/bmedj.907531

Abstract

Amaç: COVID-19 hastalığı, yaşamı tehdit etmektedir. Şiddetli hastalık seyrini ön görmek, hastalık takibinde önemlidir. Çalışmamızda elektrolit bozukluklarının COVID-19 nedeniyle hastaneye yatırılan hastaların klinik seyrine etkisini değerlendirmeyi amaçladık. Materyal ve metod: COVID-19 tanısı alan ve 11.03.2020-30.05.2020 tarihleri arasında yatarak tedavi gören hastalar çalışmaya alındı. Demografik özellikler, komorbiditeler, semptomlar, klinik seyir, laboratuvar parametreleri ve tedaviler kaydedildi. Sonuç: Çalışmaya 70'i (% 54) kadın 130 COVID-19 hastası dahil edildi. Ortalama yaş 56.6 ± 16.4 yıldı. En sık görülen semptom öksürüktü (% 57). En sık eşlik eden hastalık hipertansiyondu (% 45). Hastaların% 68'inde hiponatremi ve% 29'unda hipokalsemi vardı. Hastaların% 95'i tam iyileşme ile taburcu edildi, % 5'i öldü.Oksijen ihtiyacı ile ileri yaş, erkek cinsiyet, diabetes mellitus varlığı, kardiyovasküler hastalık, göğüs tomografisinde bilateral tutulum, lenfopeni, CRP, düşük kalsiyum seviyesi, hipokalsemi ve sekonder enfeksiyon arasında anlamlı bir ilişki vardı (sırasyla p = 0.024, p= 0,001, p = 0,030, p =0,045, p = 0,002, p = 0,010, p = 0,000, p = 0,022, p = 0,048, p = 0,001). Yoğun bakım ihtiyacı, erkek cinsiyet, düşük kalsiyum seviyesi, hiponatremi ve ikincil enfeksiyon varlığı arasında anlamlı bir ilişki vardı. (sırasıyla, p = 0,045, p = 0,023, p = 0,011 p = 0,001). Hastanede kalış süresi ile düşük kalsiyum seviyesi ve düşük sodyum seviyesi arasında anlamlı ilişki vardı (p = 0,026, p = 0,022). Tartışma: COVID-19'un şiddeti, düşük serum sodyum ve kalsiyum konsantrasyonları ile ilişkili görünmektedir, COVID-19 hastalarının takibinde düzenli elektrolit takibi faydalı olabilir.

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References

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  • Zhou F, Yu T, Du R, et al. Clinical course and risk factors for mortality of adult in patients with COVID-19 in Wuhan, China: a retrospective cohort study. Lancet 2020; 395(10229):1054-62. doi: 10.1016/S0140-6736(20)30566-3.
  • Huang I, Lim MA, Pranata R. Diabetes mellitus is associated with increased mortality and severity of disease in COVID-19 pneumonia - A systematic review, meta-analysis, and meta-regression. Diabetes Metab Syndr. Jul-Aug 2020;14(4):395- 403. doi: 10.1016/j.dsx.2020.04.018.
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  • Singh AK, Gillies CL, Singh R . Prevalence of co-morbidities and their association with mortality in patients with COVID-19: A systematic review and meta-analysis. Diabetes Obes Metab. 2020 Jun 23;10.1111/dom.14124. doi: 10.1111/dom.14124.
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  • Berni A., Malandrino D., Parenti G., Maggi M., Poggesi L., Peri A. Hyponatremia, IL-6, and SARS-CoV-2 (COVID-19) infection: may all fit together? J Endocrinol Invest. 2020
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  • Su H., Yang M., Wan C., Yi L.X., Tang F., Zhu H.Y. Renal histopathological analysis of 26 postmortem findings of patients with COVID-19 in China. Kidney Int. 2020 Jul;98(1):219-227. doi: 10.1016/j.kint.2020.04.003.
  • Yousaf Z., Al-Shokri S.D., Al-Soub H., Mohamed M.F.H. COVID-19-associated SIADH: a clue in the times of pandemic! Am J Physiol Endocrinol Metabol. 2020;318:E882–E885.

How electrolyte values affect COVID-19 patients at the time of application to the hospital?

Year 2022, Volume: 6 Issue: 1, 1 - 6, 28.02.2022
https://doi.org/10.33716/bmedj.907531

Abstract

Aim: COVID-19 disease is life threatening. we aimed to evaluated the effect of electrolyte disturbances on the course of COVID-19 disease. Material and methods: Patients hospitalized with the diagnosis of COVID-19 were included in the study. Demographic characteristics, comorbidities, symptoms, clinical course, and laboratory parameters were recorded. Results: Totally 130 COVID-19 patients, 70 (54%) of whom were female, were included in the study. The mean age was 56.6 ± 16.4 years. The most common symptom was cough (57%) and the accompanying disease hypertension (45%). 68% of the patients had hyponatremia and 29%
had hypocalcemia. 95% of the patients were discharged. 5% died. There was a relationship between the need for oxygen and advanced age, male gender, presence of diabetes mellitus, cardiovascular disease, bilateral involvement in chest CT, lymphopenia, CRP, low calcium level, hypocalcemia, and secondary infection (p = 0.024., p= 0.001, p = 0.030, p = 0.045, p = 0.002, p =0.010, p = 0.000, p = 0.022, p = 0.048, p = 0.001, respectively). There was a relationship between the need for intensive care, male gender, low calcium level, hyponatremia conclusion the presence of secondary infection. (respectively, p = 0.045, p = 0.023, p = 0.011, p = 0.001). There was a correlation between the duration of hospitalization and low calcium level and low sodium level (p = 0.026, p = 0.022). Conclusion: The severity of COVID-19 appears to be associated with
low serum sodium and calcium concentrations, and regular electrolyte monitoring can be useful in follow-up.

References

  • Guan W, Ni Z, Hu Y et al. Clinical Characteristics of Coronavirus Disease 2019 in China. N Engl J Med. 28 2020 Apr 30;382(18):1708-1720. doi: 10.1056
  • Pei G, Zhang Z, Peng J, Liu L, Zhang C, Yu C, et al. Renal Involvement and Early Prognosis in Patients with COVID-19 Pneumonia. Journal of the American Society of Nephrology : JASN. 2020.
  • Lippi G, South AM, Henry BM. Electrolyte imbalances in patients with severe coronavirus disease 2019 (COVID-19). Annals of clinical biochemistry. 2020:4563220922255.
  • Guidance to Covid-19 (SARS Cov2 infection), Turkish Health Ministry (2020)[cited 18.05.2020]. Available from: https://hsgm.saglik.gov.tr/tr/covid-19-i-ngilizce-dokumanlar.html Google Scholar
  • Huang C, Wang Y, Li X et al. Clinicalfeatures of patientsinfectedwith 2019 novelcoronavirus in Wuhan, China. Lancet 2020;395:497-506. doi: 10.1016/S0140- 6736(20)30183-5.
  • Tezcan M.E., Gokce GD, Sen N et al. Baseline electrolyte abnormalities would be related to poor prognosis in hospitalized coronavirus disease 2019 patients New Microbes New Infect. 2020 Sep; 37: 100753. doi: 10.1016/j.nmni.2020.100753
  • Roncon L , Zuin M. Diabetic patients with COVID-19 infection are at higher risk of ICU admission and poor short-term outcome. J Clin Virol. 2020 Jun; 127: 104354. doi: 10.1016/j.jcv.2020.104354
  • Guan WJ, Liang WH, Zhao Y et all. Comorbidity and Its Impact on 1590 Patients With COVID-19 in China: A Nationwide Analysis. Eur Respir J. 2020 May 14;55(5):2000547. doi: 10.1183/13993003.00547-2020
  • Yan Y. Yang Y, Wang F et all. Clinical Characteristics and Outcomes of Patients With Severe COVID-19 With Diabetes. BMJ Open Diabetes Res Care. 2020 Apr;8(1):e001343. doi: 10.1136/bmjdrc-2020-001343.
  • Zoppini G, Fedeli U, Schievano E, Dauriz M, Targher G, Bonora E, Corti MC (2018) Mortality from infectious diseases in diabetes. Nutr Metab Cardiovasc Dis 28:444–450
  • Geerlings SE, Hoepelman AI. Immune dysfunction in patients with diabetes mellitus (DM). FEMS Immunol Med Microbiol 1999; 26: 259–265.
  • Zhou F, Yu T, Du R, et al. Clinical course and risk factors for mortality of adult in patients with COVID-19 in Wuhan, China:a retrospective cohort study. Lancet 2020; 395(10229):1054-62. doi: 10.1016/S0140-6736(20)30566-3.
  • G P Fadini , M L Morieri , E Longato, A Avogaro. Prevalence and Impact of Diabetes Among People Infected With SARSCoV-2. J Endocrinol Invest. 2020 Jun;43(6):867-869.doi: 10.1007/s40618-020-01236-2.
  • Zhou F, Yu T, Du R, et al. Clinical course and risk factors for mortality of adult in patients with COVID-19 in Wuhan, China: a retrospective cohort study. Lancet 2020; 395(10229):1054-62. doi: 10.1016/S0140-6736(20)30566-3.
  • Huang I, Lim MA, Pranata R. Diabetes mellitus is associated with increased mortality and severity of disease in COVID-19 pneumonia - A systematic review, meta-analysis, and meta-regression. Diabetes Metab Syndr. Jul-Aug 2020;14(4):395- 403. doi: 10.1016/j.dsx.2020.04.018.
  • Long C, Xu H, Shen Q et al.Diagnosis of the Coronavirus disease (COVID-19): rRT-PCR or CT? Eur J Radiol. 2020 May;126:108961. doi: 10.1016/j.ejrad.2020.108961.
  • Y, Yang Z, Ai T, Wu S, Xia L.Association of “initial CT” findings with mortality in older patients with coronavirus disease 2019 (COVID-19) . Eur Radiol. 2020 Jun 10;1-8. doi: 10.1007/s00330-020-06969-5
  • Alberici F, Delbarba E, Manenti C et al.Management Of Patients On Dialysis And With Kidney Transplant During SARSCOV-2 (COVID-19) Pandemic In Brescia, Italy.Kidney Int Rep.020 Apr 4;5(5):580-585. doi: 10.1016/j.ekir.2020.04.001.
  • Singh AK, Gillies CL, Singh R . Prevalence of co-morbidities and their association with mortality in patients with COVID-19: A systematic review and meta-analysis. Diabetes Obes Metab. 2020 Jun 23;10.1111/dom.14124. doi: 10.1111/dom.14124.
  • Duan J., Wang X., Chi J., Chen H., Bai L., Hu Q. Correlation between the variables collected at admission and progression to severe cases during hospitalization among COVID-19 patients in Chongqing. J Med Virol. 2020.
  • Chawla A., Sterns R.H., Nigwekar S.U., Cappuccio J.D. Mortality and serum sodium: do patients die from or with hyponatremia? Clin J Am Soc Nephrol. 2011;6:960–965.
  • Berni A., Malandrino D., Parenti G., Maggi M., Poggesi L., Peri A. Hyponatremia, IL-6, and SARS-CoV-2 (COVID-19) infection: may all fit together? J Endocrinol Invest. 2020
  • Abbas AK, Fausto N, Kumar V. Robbins & Cotran Pathologic Basis of Disease, (Robbins Pathology). ISBN:9780808924500;2017
  • Varga Z., Flammer A.J., Steiger P., Haberecker M., Andermatt R., Zinkernagel A.S. Endothelial cell infection and endotheliitis in COVID-19. Lancet. 2020;395(10234):1417–1418.
  • Su H., Yang M., Wan C., Yi L.X., Tang F., Zhu H.Y. Renal histopathological analysis of 26 postmortem findings of patients with COVID-19 in China. Kidney Int. 2020 Jul;98(1):219-227. doi: 10.1016/j.kint.2020.04.003.
  • Yousaf Z., Al-Shokri S.D., Al-Soub H., Mohamed M.F.H. COVID-19-associated SIADH: a clue in the times of pandemic! Am J Physiol Endocrinol Metabol. 2020;318:E882–E885.
There are 26 citations in total.

Details

Primary Language English
Subjects Clinical Sciences
Journal Section RESEARCH ARTICLE
Authors

Kübra Aydın Bahat 0000-0002-2620-9991

Meral Meşe 0000-0002-6104-2058

Publication Date February 28, 2022
Published in Issue Year 2022 Volume: 6 Issue: 1

Cite

APA Aydın Bahat, K., & Meşe, M. (2022). How electrolyte values affect COVID-19 patients at the time of application to the hospital?. Balıkesir Medical Journal, 6(1), 1-6. https://doi.org/10.33716/bmedj.907531