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Transient hyperphosphatasemia following gastroenteritis: avoid over-investigation in otherwise healthy children

Yıl 2025, Cilt: 9 Sayı: 2, 109 - 113, 30.08.2025
https://doi.org/10.33716/bmedj.1617632

Öz

Serum alkaline phosphatase concentration rises in some disease states. On the other hand, benign transient hyperphosphatasemia is most commonly recognized in infants and children younger than 2 years of age. It has also been described in adults. Benign transient hyperphosphatasemia is a self-limiting condition that is usually accompanied by some infectious and allergic disorders. Therefore it is important to keep this entity in mind to avoid unnecessary investigations. Here, we report two children who were diagnosed with benign transient hyperphosphatasemia following gastroenteritis.

Kaynakça

  • Corathers S.D. (2006) The alkaline phosphatase level: nuances of a familiar test. Pediatr Rev., 27:382–384.
  • Crofton P.M. (1988) What is the cause of benign transient hyperphosphatasemia? A study of 35 cases. Clin Chem., 34:335-340.
  • Gualco G., Lava S.A., Garzoni L, et al. (2013) Transient benign hyperphophatasemia. J Pediatr Gastroenterol Nutr., 57:167-171.
  • Huh S.Y., Feldman H.A., Cox JE, Gordon CM. (2009) Prevalence of transient hyperphosphatasemia among healthy infants and toddlers. Pediatrics. 124:703–709.
  • Kraut JR, Metrick M., Maxwell NR, Kaplan MM., (1985) Isoenzyme studies in transient hyperphosphatasemia of infancy. Ten new cases and a review of the literature. Am J Dis Child., 139:736–740.
  • Otero JL, González-Peralta RP, Andres JM, Jolley CD, Novak DA, Haafiz A. (2011) Elevated Alkaline Phosphatase in Children: An Algorithm to Determine When a "Wait and See" Approach is Optimal. Clin Med Insights Pediatr., 5:15-18.
  • Schonhaut B L, Rocha R A. (2017) Hiperfosfatasemia transitoria benigna de la infancia: Serie clínica [Benign transient hyperphosphatasaemia in infants: Clinical series]. Rev Chil Pediatr., 88:169-175. Spanish. Shkalim Zemer V, Hoshen M, Levinsky Y, et al. (2023) Benign transient hyperphosphatasemia in infants and children: a retrospective database study. Eur J Pediatr. 2:1–6.

Transient hyperphosphatasemia following gastroenteritis: avoid over-investigation in otherwise healthy children

Yıl 2025, Cilt: 9 Sayı: 2, 109 - 113, 30.08.2025
https://doi.org/10.33716/bmedj.1617632

Öz

Serum alkalen fosfataz düzeyi bazı hastalık durumlarında yükselir. Öte yandan, beniyn geçici hiperfosfatazemi en sık sütçocuklarında ve 2 yaş altındaki çocuklarda görülür. Erişkinlerde de tanımlanmıştır. Beniyn geçici hiperfosfatazemi kendiliğinden düzelir ve genellikle enfeksiyöz ve allerjik hastalıklara eşlik eder. Bu nedenle, gereksiz incelemelerden kaçınmak için bu durumun akılda tutulması gerekir. Bu makalede gastroenterit sonrası beniyn geçici hiperfosfatazemi gelişen iki çocuk hasta bildirilmektedir.

Kaynakça

  • Corathers S.D. (2006) The alkaline phosphatase level: nuances of a familiar test. Pediatr Rev., 27:382–384.
  • Crofton P.M. (1988) What is the cause of benign transient hyperphosphatasemia? A study of 35 cases. Clin Chem., 34:335-340.
  • Gualco G., Lava S.A., Garzoni L, et al. (2013) Transient benign hyperphophatasemia. J Pediatr Gastroenterol Nutr., 57:167-171.
  • Huh S.Y., Feldman H.A., Cox JE, Gordon CM. (2009) Prevalence of transient hyperphosphatasemia among healthy infants and toddlers. Pediatrics. 124:703–709.
  • Kraut JR, Metrick M., Maxwell NR, Kaplan MM., (1985) Isoenzyme studies in transient hyperphosphatasemia of infancy. Ten new cases and a review of the literature. Am J Dis Child., 139:736–740.
  • Otero JL, González-Peralta RP, Andres JM, Jolley CD, Novak DA, Haafiz A. (2011) Elevated Alkaline Phosphatase in Children: An Algorithm to Determine When a "Wait and See" Approach is Optimal. Clin Med Insights Pediatr., 5:15-18.
  • Schonhaut B L, Rocha R A. (2017) Hiperfosfatasemia transitoria benigna de la infancia: Serie clínica [Benign transient hyperphosphatasaemia in infants: Clinical series]. Rev Chil Pediatr., 88:169-175. Spanish. Shkalim Zemer V, Hoshen M, Levinsky Y, et al. (2023) Benign transient hyperphosphatasemia in infants and children: a retrospective database study. Eur J Pediatr. 2:1–6.
Toplam 7 adet kaynakça vardır.

Ayrıntılar

Birincil Dil İngilizce
Konular Klinik Tıp Bilimleri (Diğer)
Bölüm OLGU SUNUMU
Yazarlar

Gizem Yıldız 0000-0001-9513-6661

Erkam Yıldırım 0000-0002-5574-8214

Meral Torun Bayram 0000-0003-3760-7028

Salih Kavukçu 0000-0002-9959-881X

Alper Soylu 0000-0002-5901-7398

Erken Görünüm Tarihi 28 Ağustos 2025
Yayımlanma Tarihi 30 Ağustos 2025
Gönderilme Tarihi 11 Ocak 2025
Kabul Tarihi 20 Ağustos 2025
Yayımlandığı Sayı Yıl 2025 Cilt: 9 Sayı: 2

Kaynak Göster

APA Yıldız, G., Yıldırım, E., Torun Bayram, M., … Kavukçu, S. (2025). Transient hyperphosphatasemia following gastroenteritis: avoid over-investigation in otherwise healthy children. Balıkesir Medical Journal, 9(2), 109-113. https://doi.org/10.33716/bmedj.1617632