Transient hyperphosphatasemia following gastroenteritis: avoid over-investigation in otherwise healthy children
Yıl 2025,
Cilt: 9 Sayı: 2, 109 - 113, 30.08.2025
Gizem Yıldız
,
Erkam Yıldırım
,
Meral Torun Bayram
,
Salih Kavukçu
,
Alper Soylu
Öz
Serum alkaline phosphatase concentration rises in some disease states. On the other hand, benign transient hyperphosphatasemia is most commonly recognized in infants and children younger than 2 years of age. It has also been described in adults. Benign transient hyperphosphatasemia is a self-limiting condition that is usually accompanied by some infectious and allergic disorders. Therefore it is important to keep this entity in mind to avoid unnecessary investigations. Here, we report two children who were diagnosed with benign transient hyperphosphatasemia following gastroenteritis.
Kaynakça
-
Corathers S.D. (2006) The alkaline phosphatase level: nuances of a familiar test. Pediatr Rev., 27:382–384.
-
Crofton P.M. (1988) What is the cause of benign transient hyperphosphatasemia? A study of 35 cases. Clin Chem., 34:335-340.
-
Gualco G., Lava S.A., Garzoni L, et al. (2013) Transient benign hyperphophatasemia. J Pediatr Gastroenterol Nutr., 57:167-171.
-
Huh S.Y., Feldman H.A., Cox JE, Gordon CM. (2009) Prevalence of transient hyperphosphatasemia among healthy infants and toddlers. Pediatrics. 124:703–709.
-
Kraut JR, Metrick M., Maxwell NR, Kaplan MM., (1985) Isoenzyme studies in transient hyperphosphatasemia of infancy. Ten new cases and a review of the literature. Am J Dis Child., 139:736–740.
-
Otero JL, González-Peralta RP, Andres JM, Jolley CD, Novak DA, Haafiz A. (2011) Elevated Alkaline Phosphatase in Children: An Algorithm to Determine When a "Wait and See" Approach is Optimal. Clin Med Insights Pediatr., 5:15-18.
-
Schonhaut B L, Rocha R A. (2017) Hiperfosfatasemia transitoria benigna de la infancia: Serie clínica [Benign transient hyperphosphatasaemia in infants: Clinical series]. Rev Chil Pediatr., 88:169-175. Spanish.
Shkalim Zemer V, Hoshen M, Levinsky Y, et al. (2023) Benign transient hyperphosphatasemia in infants and children: a retrospective database study. Eur J Pediatr. 2:1–6.
Transient hyperphosphatasemia following gastroenteritis: avoid over-investigation in otherwise healthy children
Yıl 2025,
Cilt: 9 Sayı: 2, 109 - 113, 30.08.2025
Gizem Yıldız
,
Erkam Yıldırım
,
Meral Torun Bayram
,
Salih Kavukçu
,
Alper Soylu
Öz
Serum alkalen fosfataz düzeyi bazı hastalık durumlarında yükselir. Öte yandan, beniyn geçici hiperfosfatazemi en sık sütçocuklarında ve 2 yaş altındaki çocuklarda görülür. Erişkinlerde de tanımlanmıştır. Beniyn geçici hiperfosfatazemi kendiliğinden düzelir ve genellikle enfeksiyöz ve allerjik hastalıklara eşlik eder. Bu nedenle, gereksiz incelemelerden kaçınmak için bu durumun akılda tutulması gerekir. Bu makalede gastroenterit sonrası beniyn geçici hiperfosfatazemi gelişen iki çocuk hasta bildirilmektedir.
Kaynakça
-
Corathers S.D. (2006) The alkaline phosphatase level: nuances of a familiar test. Pediatr Rev., 27:382–384.
-
Crofton P.M. (1988) What is the cause of benign transient hyperphosphatasemia? A study of 35 cases. Clin Chem., 34:335-340.
-
Gualco G., Lava S.A., Garzoni L, et al. (2013) Transient benign hyperphophatasemia. J Pediatr Gastroenterol Nutr., 57:167-171.
-
Huh S.Y., Feldman H.A., Cox JE, Gordon CM. (2009) Prevalence of transient hyperphosphatasemia among healthy infants and toddlers. Pediatrics. 124:703–709.
-
Kraut JR, Metrick M., Maxwell NR, Kaplan MM., (1985) Isoenzyme studies in transient hyperphosphatasemia of infancy. Ten new cases and a review of the literature. Am J Dis Child., 139:736–740.
-
Otero JL, González-Peralta RP, Andres JM, Jolley CD, Novak DA, Haafiz A. (2011) Elevated Alkaline Phosphatase in Children: An Algorithm to Determine When a "Wait and See" Approach is Optimal. Clin Med Insights Pediatr., 5:15-18.
-
Schonhaut B L, Rocha R A. (2017) Hiperfosfatasemia transitoria benigna de la infancia: Serie clínica [Benign transient hyperphosphatasaemia in infants: Clinical series]. Rev Chil Pediatr., 88:169-175. Spanish.
Shkalim Zemer V, Hoshen M, Levinsky Y, et al. (2023) Benign transient hyperphosphatasemia in infants and children: a retrospective database study. Eur J Pediatr. 2:1–6.