The relationship between the inflammatory markers and arterial distensibility in patients with sarcoidosis

Abstract

Objectives: Sarcoidosis is a multisystem disorder of unknown etiology and is characterized by noncaseating granulomas in organs. The purpose of this study was to test the hypothesis that chronic inflammation may impair arterial function and lead to an increase in arterial pulse wave velocity (PWV) in patients with sarcoidosis. Patients and Methods: We recruited 19 patients (12 women, 7 men) with sarcoidosis, and 19 sex-matched healthy controls. Aortic PWV was determined by using an automatic device, the Complior Colson (France), which allowed on-line pulse wave recording and automatic calculation of PWV. Results: The PWV, glucose, LDL cholesterol, uric acid, high-sensitivity C-reactive protein and erythrocyte sedimentation rate were higher in patients with sarcoidosis than in control subjects (p=0.04, p=0.03, p=0.02, p=0.008, p=0.04, p=0.005, respectively). We found significant correlation between PWV and age (p=0.001, r=0.52), body mass index (p=0.01, r=0.40), systolic blood pressure (p<0.001, r=0.71), diastolic blood pressure (p<0.001, r=0.63), mean blood pressure (p<0.001, r=0.68), pulse pressure (p<0.001, r=0.63), pulse transit time (p<0.001, r=-0.90), total cholesterol (p=0.002, r=0.47) and LDL cholesterol (p=0.001, r=0.51). Conclusion: The carotid-femoral (aortic) PWV was higher in patients with sarcoidosis than in control subjects. PWV is influenced by total cholesterol, LDL cholesterol, age, body-mass index and blood pressure level. Amaç: Sarkoidoz, etyolojisi bilinmeyen, organlarda nonkazeöz granulomlarla karakterize bir multisistem hastalıktır. Bu çalışmanın amacı, kronik inflamasyon arteriyel fonksiyonları bozabilir ve sarkoidozlu hastalarda arteriyel nabız dalga hızında (NDH) artışa yol açabilir hipotezini araştırmaktır. Hastalar ve Yöntemler: Çalışmaya toplam 19 sarkoidozlu hasta (12 kadın, 7 erkek) ve benzer cinsiyette 19 sağlıklı kişiden oluşan kontrol grubu dahil edildi. Aortik NDH, otomatik online nabız dalga kaydına ve nabız dalga hızının otomatik hesaplanmasına imkan veren Complior cihazı (Fransa) kullanılarak hesaplandı. Bulgular: NDH, glükoz, LDL kolesterol, ürik asit, yüksek duyarlıklı C-reaktif protein ve eritrosit sedimentasyon hızı sarkoidozlu hasta grubunda kontrol grubuna göre daha yüksekti (sırası ile p=0.04, p=0.03, p=0.02, p=0.008, p=0.04, p=0.005). NDH ile yaş (p=0.001, r=0.52), vücut kitle indeksi (p=0.01, r=0.40), sistolik kan basıncı (p<0.001, r=0.71), diastolik kan basıncı (p<0.001, r=0.63), ortalama kan basıncı (p<0.001, r=0.68), nabız basıncı (p<0.001, r=0.63), nabız dalgası ilerleme zamanı (p<0.001, r=-0.90), total kolesterol (p=0.002, r=0.47) ve LDL kolesterol (p=0.001, r=0.51) arasında anlamlı korelasyon saptandı. Sonuç: Karotis-femoral (aortik) NDH sarkoidozlu hastalarda kontrollere göre daha yüksekti. NDH total kolesterol, LDL kolesterol, yaş, vücut kitle indeksi ve kan basıncı seviyelerinden etkilenmektedir.

Keywords

• Pulse wave velocity; arterial stiffness; sarcoidosis; blood pressure; inflammation

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