Primary Sinonasal Malignant Melanoma: Effect of Clinical and Histopathologic Prognostic Factors on Survival

Sercan Göde; Göksel Turhal; Ceyda Tarhan; Banu Yaman; Gülşen Kandiloğlu; Kerem Öztürk; İsa Kaya; Raşit Midilli; Bülent Karcı

Primary Sinonasal Malignant Melanoma: Effect of Clinical and Histopathologic Prognostic Factors on Survival

Year 2017, Volume: 34 Issue: 3, 255 - 262, 01.05.2017

Sercan Göde Göksel Turhal Ceyda Tarhan Banu Yaman Gülşen Kandiloğlu Kerem Öztürk İsa Kaya Raşit Midilli Bülent Karcı

Abstract

Background: Mucosal melanoma is a rare malignancy arising from melanocytes of the mucosal surfaces. The pattern and frequency of oncogenic mutations and histopathological biomarkers have a role on distinct tumour behaviour and survival. Aims: To assess the rate of C-KIT positivity and its effect on survival of surgically treated sinonasal malignant melanoma patients with other histopathological biomarkers and clinical features. Study Design: Retrospective cross-sectional study. Methods: Seventeen sinonasal malignant melanoma patients with a mean age of 65.41 (39-86) years were included. Overall survival and disease-specific survival rates were calculated. The impact of age, gender, stage and extent of the disease, type of surgery, and adjuvant therapies were also taken into consideration. The effect of mitotic index, pigmentation, S100, HMB-45, Melan-A and C-KIT on survival were evaluated. Results: Median tumour size was 20 mm (interquartile range=27.5 mm). Pigmentation was present in 7 (41.2%) cases. Median number of mitoses per millimetre squared was 11 (interquartile range=13). Melan A was positive in 7 (41.2%) patients, ulceration was present in 6 cases (35.3%), and necrosis was present in (47.1%) 8 cases. Six patients (35.3%) were positive for S100, 14 (82.4%) specimens stained positive for HMB-45 and C-KIT (CD117) was positive in 9 cases (52.9%). Three patients (16.7%) developed distant metastasis. Five year overall and disease free survival rates were 61.4% and 43.8%, respectively. Conclusion: Although C-KIT positive sinonasal malignant melanoma patients (52.9%) can be candidates for targeted tumour therapies, the studied clinical or histopathological features along with C-KIT seem to have no significant effect on survival in a small group of patients with sinonasal malignant melanoma.

Keywords

Malignant melanoma, nasal cavity, paranasal sinuses, C-KIT, sinonasal malignancy, mucosal melanoma

Year 2017, Volume: 34 Issue: 3, 255 - 262, 01.05.2017

Sercan Göde Göksel Turhal Ceyda Tarhan Banu Yaman Gülşen Kandiloğlu Kerem Öztürk İsa Kaya Raşit Midilli Bülent Karcı

Abstract

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Details

Other ID	JA24KA85PU
Journal Section	Research Article
Authors	Sercan Göde This is me Göksel Turhal This is me Ceyda Tarhan This is me Banu Yaman This is me Gülşen Kandiloğlu This is me Kerem Öztürk This is me İsa Kaya This is me Raşit Midilli This is me Bülent Karcı This is me
Publication Date	May 1, 2017
Published in Issue	Year 2017 Volume: 34 Issue: 3

Cite

APA	Göde, S., Turhal, G., Tarhan, C., Yaman, B., et al. (2017). Primary Sinonasal Malignant Melanoma: Effect of Clinical and Histopathologic Prognostic Factors on Survival. Balkan Medical Journal, 34(3), 255-262.
AMA	Göde S, Turhal G, Tarhan C, Yaman B, Kandiloğlu G, Öztürk K, Kaya İ, Midilli R, Karcı B. Primary Sinonasal Malignant Melanoma: Effect of Clinical and Histopathologic Prognostic Factors on Survival. Balkan Medical Journal. May 2017;34(3):255-262.
Chicago	Göde, Sercan, Göksel Turhal, Ceyda Tarhan, Banu Yaman, Gülşen Kandiloğlu, Kerem Öztürk, İsa Kaya, Raşit Midilli, and Bülent Karcı. “Primary Sinonasal Malignant Melanoma: Effect of Clinical and Histopathologic Prognostic Factors on Survival”. Balkan Medical Journal 34, no. 3 (May 2017): 255-62.
EndNote	Göde S, Turhal G, Tarhan C, Yaman B, Kandiloğlu G, Öztürk K, Kaya İ, Midilli R, Karcı B (May 1, 2017) Primary Sinonasal Malignant Melanoma: Effect of Clinical and Histopathologic Prognostic Factors on Survival. Balkan Medical Journal 34 3 255–262.
IEEE	S. Göde, “Primary Sinonasal Malignant Melanoma: Effect of Clinical and Histopathologic Prognostic Factors on Survival”, Balkan Medical Journal, vol. 34, no. 3, pp. 255–262, 2017.
ISNAD	Göde, Sercan et al. “Primary Sinonasal Malignant Melanoma: Effect of Clinical and Histopathologic Prognostic Factors on Survival”. Balkan Medical Journal 34/3 (May 2017), 255-262.
JAMA	Göde S, Turhal G, Tarhan C, Yaman B, Kandiloğlu G, Öztürk K, Kaya İ, Midilli R, Karcı B. Primary Sinonasal Malignant Melanoma: Effect of Clinical and Histopathologic Prognostic Factors on Survival. Balkan Medical Journal. 2017;34:255–262.
MLA	Göde, Sercan et al. “Primary Sinonasal Malignant Melanoma: Effect of Clinical and Histopathologic Prognostic Factors on Survival”. Balkan Medical Journal, vol. 34, no. 3, 2017, pp. 255-62.
Vancouver	Göde S, Turhal G, Tarhan C, Yaman B, Kandiloğlu G, Öztürk K, Kaya İ, Midilli R, Karcı B. Primary Sinonasal Malignant Melanoma: Effect of Clinical and Histopathologic Prognostic Factors on Survival. Balkan Medical Journal. 2017;34(3):255-62.