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Primary Sinonasal Malignant Melanoma: Effect of Clinical and Histopathologic Prognostic Factors on Survival

Yıl 2017, Cilt: 34 Sayı: 3, 255 - 262, 01.05.2017

Sercan Göde Göksel Turhal Ceyda Tarhan Banu Yaman Gülşen Kandiloğlu Kerem Öztürk İsa Kaya Raşit Midilli Bülent Karcı

Öz

Background: Mucosal melanoma is a rare malignancy arising from melanocytes of the mucosal surfaces. The pattern and frequency of oncogenic mutations and histopathological biomarkers have a role on distinct tumour behaviour and survival. Aims: To assess the rate of C-KIT positivity and its effect on survival of surgically treated sinonasal malignant melanoma patients with other histopathological biomarkers and clinical features. Study Design: Retrospective cross-sectional study. Methods: Seventeen sinonasal malignant melanoma patients with a mean age of 65.41 (39-86) years were included. Overall survival and disease-specific survival rates were calculated. The impact of age, gender, stage and extent of the disease, type of surgery, and adjuvant therapies were also taken into consideration. The effect of mitotic index, pigmentation, S100, HMB-45, Melan-A and C-KIT on survival were evaluated. Results: Median tumour size was 20 mm (interquartile range=27.5 mm). Pigmentation was present in 7 (41.2%) cases. Median number of mitoses per millimetre squared was 11 (interquartile range=13). Melan A was positive in 7 (41.2%) patients, ulceration was present in 6 cases (35.3%), and necrosis was present in (47.1%) 8 cases. Six patients (35.3%) were positive for S100, 14 (82.4%) specimens stained positive for HMB-45 and C-KIT (CD117) was positive in 9 cases (52.9%). Three patients (16.7%) developed distant metastasis. Five year overall and disease free survival rates were 61.4% and 43.8%, respectively. Conclusion: Although C-KIT positive sinonasal malignant melanoma patients (52.9%) can be candidates for targeted tumour therapies, the studied clinical or histopathological features along with C-KIT seem to have no significant effect on survival in a small group of patients with sinonasal malignant melanoma.

Anahtar Kelimeler

Malignant melanoma nasal cavity paranasal sinuses C-KIT sinonasal malignancy mucosal melanoma

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Ayrıntılar

Diğer ID JA24KA85PU
Bölüm Araştırma Makalesi
Yazarlar

Sercan Göde Bu kişi benim

Göksel Turhal Bu kişi benim

Ceyda Tarhan Bu kişi benim

Banu Yaman Bu kişi benim

Gülşen Kandiloğlu Bu kişi benim

Kerem Öztürk Bu kişi benim

İsa Kaya Bu kişi benim

Raşit Midilli Bu kişi benim

Bülent Karcı Bu kişi benim

Yayımlanma Tarihi 1 Mayıs 2017
Yayımlandığı Sayı Yıl 2017 Cilt: 34 Sayı: 3

Kaynak Göster

APA Göde, S., Turhal, G., Tarhan, C., Yaman, B., vd. (2017). Primary Sinonasal Malignant Melanoma: Effect of Clinical and Histopathologic Prognostic Factors on Survival. Balkan Medical Journal, 34(3), 255-262.
AMA Göde S, Turhal G, Tarhan C, Yaman B, Kandiloğlu G, Öztürk K, Kaya İ, Midilli R, Karcı B. Primary Sinonasal Malignant Melanoma: Effect of Clinical and Histopathologic Prognostic Factors on Survival. Balkan Medical Journal. Mayıs 2017;34(3):255-262.
Chicago Göde, Sercan, Göksel Turhal, Ceyda Tarhan, Banu Yaman, Gülşen Kandiloğlu, Kerem Öztürk, İsa Kaya, Raşit Midilli, ve Bülent Karcı. “Primary Sinonasal Malignant Melanoma: Effect of Clinical and Histopathologic Prognostic Factors on Survival”. Balkan Medical Journal 34, sy. 3 (Mayıs 2017): 255-62.
EndNote Göde S, Turhal G, Tarhan C, Yaman B, Kandiloğlu G, Öztürk K, Kaya İ, Midilli R, Karcı B (01 Mayıs 2017) Primary Sinonasal Malignant Melanoma: Effect of Clinical and Histopathologic Prognostic Factors on Survival. Balkan Medical Journal 34 3 255–262.
IEEE S. Göde, “Primary Sinonasal Malignant Melanoma: Effect of Clinical and Histopathologic Prognostic Factors on Survival”, Balkan Medical Journal, c. 34, sy. 3, ss. 255–262, 2017.
ISNAD Göde, Sercan vd. “Primary Sinonasal Malignant Melanoma: Effect of Clinical and Histopathologic Prognostic Factors on Survival”. Balkan Medical Journal 34/3 (Mayıs 2017), 255-262.
JAMA Göde S, Turhal G, Tarhan C, Yaman B, Kandiloğlu G, Öztürk K, Kaya İ, Midilli R, Karcı B. Primary Sinonasal Malignant Melanoma: Effect of Clinical and Histopathologic Prognostic Factors on Survival. Balkan Medical Journal. 2017;34:255–262.
MLA Göde, Sercan vd. “Primary Sinonasal Malignant Melanoma: Effect of Clinical and Histopathologic Prognostic Factors on Survival”. Balkan Medical Journal, c. 34, sy. 3, 2017, ss. 255-62.
Vancouver Göde S, Turhal G, Tarhan C, Yaman B, Kandiloğlu G, Öztürk K, Kaya İ, Midilli R, Karcı B. Primary Sinonasal Malignant Melanoma: Effect of Clinical and Histopathologic Prognostic Factors on Survival. Balkan Medical Journal. 2017;34(3):255-62.