The Possible Effects of Nutrition and Microbiota on Depression

Year 2022, , 156 - 165, 28.08.2022

Elif Nida Koç , Emre Duman

https://doi.org/10.46413/boneyusbad.1105519

Abstract

Depression is common mental disorder which affects more than 300 million people worldwide. Treatment of depression’s methods have low positive effect and high side effect on patients. Therefore, new treatment methods have being researched. Studies show that microbiota can affect both occurence and treatment of depression because of secretes neurotransmitter and endocrine, inflammation and immune mechanism, brain derived neurotrophic factor (BDNF), hypothalamic pituitary adrenal (HPA) axis. Nutrition, on the other hand, is an issue that should be considered because of its effect on both the microbiota and depression. Therefore, the effects of nutrition and microbiota on depression have been discussed in the light of the evidence based data.

Keywords

Microbiota, Depression, Nutrition

Beslenme ve Mikrobiyotanın Depresyon Üzerine Olası Etkileri

Abstract

Depresyon, dünya çapında 300 milyondan fazla insanın etkilendiği, yaygın olarak görülen bir duygu durum bozukluğudur. Depresyonu tedavi etmek için uygulanan yöntemlerin olumlu etkilerinin düşük ve yan etki oranlarının yüksek olması farklı tedavi arayışlarına yol açmaktadır. Nörotransmitter ve endokrin salgılar, inflamasyon ve bağışıklık mekanizmaları, beyinden türetilen nörotrofik faktör (BDNF) ve hipotalamus hipofiz adrenal aksı (HPA) gibi faktörler aracılığıyla bağırsak mikrobiyotası ile beyin arasındaki iletişimin depresyon oluşumu ve tedavisinde etkili olabileceği yapılan çalışmalarla ortaya konmuştur. Beslenme ise hem mikrobiyota hem de depresyon üzerindeki etkilerinden dolayı önemsenmesi gereken bir konudur. Bu nedenle beslenmenin ve mikrobiyotanın depresyon üzerine etkileri kanıta dayalı veriler ışığında tartışılmıştır.

Keywords

Mikrobiyota, Depresyon, Beslenme

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