Boron determination in serum and plasma of rats administered boron citrate

Abstract

Boron is a dynamic trace element that is very important for animal and human biology. Boron citrate is one of the most common forms of boron uptake into metabolism. In this study, the amount of boron was determined by ICP-MS method in both plasma and serum of rats administered boron citrate orally. Boron concentrations in serum and plasma samples taken at different times from rats administered orally 20 mg/kg boron citrate were determined and the graph of change over time was examined. It was observed that serum and plasma boron levels reached the maximum in 0.25 hours after boron citrate was applied, and boron level decreased to normal plasma and serum levels after 48 hours. We think that this study will form the basis for boron analysis and pharmacokinetic properties of boron.

Keywords

• Boron citrate
• ICP-MS
• Plasma
• Rat
• Serum

Bor sitrat uygulanan ratların serum ve plazmalarında bor tayini

Abstract

Bor, hayvan ve insan biyolojisi için çok önemli olan dinamik bir eser elementtir. Bor sitrat, borun metabolizmaya alımındaki en yaygın formlardan biridir. Bu çalışmada oral olarak bor sitrat uygulanan ratların hem plazmalarında hem de serumlarında ICP-MS yöntemi ile bor miktarı tayin edilmiş ve oral olarak 20 mg/kg bor sitrat uygulanan ratlardan farklı zamanlarda alınan serum ve plazma numunelerindeki bor konsantrasyonları tayin edilerek zamana göre değişim grafiği incelenmiştir. Bor sitrat ugulandıkdan sonra 0,25. saatte serum ve plazma bor seviyesinin maksimuma ulaştığı, 48. saatten sonra bor seviyesinin normal plazma ve serum seviyesine indiği görülmüştür. Bu çalışmanın bor analizleri ve borun farmakokinetik özellikleri açısından temel teşkil edeceğini düşünmekteyiz.

Keywords

• bor sitrat
• ICP-MS
• Plazma
• Rat
• Serum

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