AKUT PULMONER EMBOLİ HASTALARINDA GALECTİN-3 Galectin-3 in Patients with Acute Pulmonary Embolism

Mustafa Çelik; Ahmet Avcı; Recep Karataş; Ahmet Erseçgin; Fikret Keleş; Ahmet Yılmaz; Fatmagül Can; Erdoğan Sökmen; Murat Erer

doi:10.16919/bozoktip.526355

AKUT PULMONER EMBOLİ HASTALARINDA GALECTİN-3 Galectin-3 in Patients with Acute Pulmonary Embolism

Abstract

ÖZET Amaç: Pulmoner emboli (PE) göreceli olarak yaygın bir kardiyovasküler acil durumdur ve spesifik olmayan klinik tablo nedeniyle gözden kaçırılabilecek zor bir tanıdır. PE patogenezi iyi tanımlanmış olmasına rağmen, PE teşhisine yardımcı olabilecek klinik bir biyobelirteçlere ihtiyaç vardır. Teorik olarak, Galectin-3'ün (Gal-3) prokoagülan etkisinden dolayı, PE patogenezinde rol alabileceği düşünülebilir. Bu çalışmanın amacı, akut PE hastalarında Gal-3 düzeyinin önemini göstermek ve PE'nin ekokardiyografik özellikleri ile ilişkisini tanımlamaktır. Yöntem: 2013 - 2014 tarihleri arasında ardışık 40 PE hastası (26 kadın, ort. Yaş 60.93 ± 14.28 yıl) ve 40 yaş uyumlu sağlıklı kontrol çalışmaya dahil edildi. Gal-3, D-dimer ve Troponin I düzeyleri ölçüldü. PE ve kontrol grubundaki tüm hastalara transtorasik ekokardiyografik inceleme yapıldı. Bulgular: Gal-3 ve D-dimer düzeyleri PE' li hastalarda kontrollere göre anlamlı derecede yüksek bulundu. (17.04 ± 6.6 ve 8.22 ± 4.9, p <0.001) Gal-3 seviyeleri, D- dimer (r = 0.595, p <0.001) ve Troponin I değerleri (r = 0.452, p <0.001) ile anlamlı bir korelasyon gösterdi. Gal-3 seviyeleri ekokardiyografik parametrelerle anlamlı korelasyon gösterdi. ROC eğrisi analizinde, %82.5 duyarlılık ve %82.7 özgüllük ile akut PE tanısı için gereken seviye 11.43 ng / ml idi. Eğri altındaki alan % 95 CI 0.79-0.96 (p <0.001) ile 0.88 idi. Sonuç: Bu çalışmada akut PE' li hastalarda Gal-3'ün rolü gösterilmiştir. Gal-3, akut PE' yi teşhis etmek için kullanılabilecek biyobelirteçler arasında yer alabilir. Ancak daha kapsamlı çalışmalara ihtiyaç vardır. Anahtar Kelimeler: Galectin-3; D-dimer; Akut pulmoner emboli; Biyomarker; Ekokardiyografi ABSTRACT Background: Pulmonary embolism (PE) is a relatively common cardiovascular emergency and it is a difficult diagnosis that may be missed because of non-specific clinical presentation. Although the pathogenesis of PE has been well described, there is a clinical need for biomarkers that can aid the diagnosis of PE. Theoretically, because of the procoagulant effect of Galectin-3 (Gal-3), this marker may play a role in the pathogenesis of PE. The aim of the present study is to show the significance of the level of Gal-3 in patients with acute PE and identify a relation to the echocardiographic features of PE. Methods: Between 2013-2014, 40 consecutive PE patients (26 females, mean age 60.93±14.28 years) and 40 age-matched healthy controls were included in this study. Gal-3, D-dimer, and Troponin I were measured. All patients with PE and control subjects underwent transthoracic echocardiographic examination. Results: Gal-3 and D-dimer levels were significantly higher in patients with PE when compared with controls (17.04±6.6 vs 8.22±4.9, p<0.001). Gal-3 levels showed a significant correlation with D-dimer (r=0.595, p<0.001) and Troponin I values (r=0.452, p<0.001). Gal-3 levels showed significant correlation with echocardiographic parameters. In the receiver operating characteristics (ROC) curve analysis, the level required for a diagnosis of acute PE with a sensitivity of 82.5% and specificity of 82.7% was 11.43 ng/ml. The area under the curve was 0.88 with a 95% CI of 0.79-0.96 (p < 0.001). Conclusion: In the present study, we demonstrated the role of Gal-3 in patients with acute PE. Gal-3 can be used to diagnose acute PE. Keywords: Galectin-3; D-dimer; Acute pulmonary embolism; Biomarker; Echocardiography

Keywords

AKUT PULMONER EMBOLİ HASTALARINDA GALECTİN-3 Galectin-3 in Patients with Acute Pulmonary Embolism

References

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Details

Primary Language

Turkish

Subjects

Health Care Administration

Journal Section

Research Article

Authors

Mustafa Çelik ^* This is me
Türkiye

Ahmet Avcı This is me
Türkiye

Recep Karataş This is me
Türkiye

Ahmet Erseçgin This is me
Türkiye

Fikret Keleş This is me
Türkiye

Ahmet Yılmaz
Türkiye

Fatmagül Can This is me
Türkiye

Erdoğan Sökmen This is me
Türkiye

Murat Erer This is me
Türkiye

Publication Date

March 25, 2020

Submission Date

March 1, 2020

Acceptance Date

-

Published in Issue

Year 2020 Volume: 10 Number: 1

DOI

https://doi.org/10.16919/bozoktip.526355

IZ

https://izlik.org/JA26SH52FH

Cite

RIS / Bibtex

APA

Çelik, M., Avcı, A., Karataş, R., Erseçgin, A., Keleş, F., Yılmaz, A., Can, F., Sökmen, E., & Erer, M. (2020). AKUT PULMONER EMBOLİ HASTALARINDA GALECTİN-3 Galectin-3 in Patients with Acute Pulmonary Embolism. Bozok Tıp Dergisi, 10(1), 75-82. https://doi.org/10.16919/bozoktip.526355

AMA

1.Çelik M, Avcı A, Karataş R, et al. AKUT PULMONER EMBOLİ HASTALARINDA GALECTİN-3 Galectin-3 in Patients with Acute Pulmonary Embolism. Bozok Tıp Dergisi. 2020;10(1):75-82. doi:10.16919/bozoktip.526355

Chicago

Çelik, Mustafa, Ahmet Avcı, Recep Karataş, et al. 2020. “AKUT PULMONER EMBOLİ HASTALARINDA GALECTİN-3 Galectin-3 in Patients With Acute Pulmonary Embolism”. Bozok Tıp Dergisi 10 (1): 75-82. https://doi.org/10.16919/bozoktip.526355.

EndNote

Çelik M, Avcı A, Karataş R, Erseçgin A, Keleş F, Yılmaz A, Can F, Sökmen E, Erer M (March 1, 2020) AKUT PULMONER EMBOLİ HASTALARINDA GALECTİN-3 Galectin-3 in Patients with Acute Pulmonary Embolism. Bozok Tıp Dergisi 10 1 75–82.

IEEE

[1]M. Çelik et al., “AKUT PULMONER EMBOLİ HASTALARINDA GALECTİN-3 Galectin-3 in Patients with Acute Pulmonary Embolism”, Bozok Tıp Dergisi, vol. 10, no. 1, pp. 75–82, Mar. 2020, doi: 10.16919/bozoktip.526355.

ISNAD

Çelik, Mustafa - Avcı, Ahmet - Karataş, Recep - Erseçgin, Ahmet - Keleş, Fikret - Yılmaz, Ahmet - Can, Fatmagül - Sökmen, Erdoğan - Erer, Murat. “AKUT PULMONER EMBOLİ HASTALARINDA GALECTİN-3 Galectin-3 in Patients With Acute Pulmonary Embolism”. Bozok Tıp Dergisi 10/1 (March 1, 2020): 75-82. https://doi.org/10.16919/bozoktip.526355.

JAMA

1.Çelik M, Avcı A, Karataş R, Erseçgin A, Keleş F, Yılmaz A, Can F, Sökmen E, Erer M. AKUT PULMONER EMBOLİ HASTALARINDA GALECTİN-3 Galectin-3 in Patients with Acute Pulmonary Embolism. Bozok Tıp Dergisi. 2020;10:75–82.

MLA

Çelik, Mustafa, et al. “AKUT PULMONER EMBOLİ HASTALARINDA GALECTİN-3 Galectin-3 in Patients With Acute Pulmonary Embolism”. Bozok Tıp Dergisi, vol. 10, no. 1, Mar. 2020, pp. 75-82, doi:10.16919/bozoktip.526355.

Vancouver

1.Mustafa Çelik, Ahmet Avcı, Recep Karataş, Ahmet Erseçgin, Fikret Keleş, Ahmet Yılmaz, Fatmagül Can, Erdoğan Sökmen, Murat Erer. AKUT PULMONER EMBOLİ HASTALARINDA GALECTİN-3 Galectin-3 in Patients with Acute Pulmonary Embolism. Bozok Tıp Dergisi. 2020 Mar. 1;10(1):75-82. doi:10.16919/bozoktip.526355