SELENYUMUN İNSAN SAĞLIĞI ÜZERİNE ETKİLERİ VE DİYABETES MELLİTUSLA İLİŞKİSİ Effects of Selenium on Human Health and its Relationship With Diabetes Mellitus
Abstract
ÖZET
Selenyum tiroid hormonu metabolizması, antioksidan savunma ve immün sistemin düzenlenmesi
başta olmak üzere vücutta birçok mekanizmada rol alan ve birçok enzime kofaktör olarak
katılan esansiyel bir elementtir. Selenyum eksikliğinin yaşlanma, kanser, insülin direnci, diyabet,
kardiyovasküler ve nörodejeneratif hastalıklar, artmış mortalite riski, immün sistem hastalıklarıyla
ile ilişkili olabileceği belirtilmektedir. Serum selenyum seviyesini istenilen düzeyde tutmak için
selenyumdan zengin olan besinler yeterli miktarda diyette yer almalıdır. Selenyumun diyabetes
mellitus ile ilişkisinde literatürde çelişkili veriler bulunmakta bu nedenle, mekanizması tam olarak
açıklanamamaktadır. Sonuç olarak selenyunum diyabetle ile ilişkisinin hangi düzeyde olduğunun
belirlenmesi için daha fazla çalışma yapılması gerekmektedir.
Anahtar Kelimeler: Selenyum; İnsan Sağlığı; Optimal alım; Diyabetes mellitus
ABSTRACT
Selenium is an essential element involved in many mechanisms in the body, especially in thyroid
hormone metabolism, antioxidant defense and regulation of the immune system, and involved
as a cofactor in many enzymes. It is reported that selenium deficiency might be associated with
aging, cancer, insulin resistance, diabetes, cardiovascular and neurodegenerative diseases, increased
mortality risk and immune system diseases. To keep serum selenium level at desired levels
it should be included in the diet. In the literature, there are contradictory data about the relationship
of selenium with diabetes mellitus, therefore the mechanism cannot be fully explained.
As a conclusion, more studies need to be for determining the level of association with selenium
and diabetes.
Keywords: Selenium; Human health; Optimal intake; Diabetes mellitus
References
- 1. Tajaddini MH, Keikha M, Razzazzadeh A, Kelishadi R. A systematic review on the association of serum selenium and metabolic syndrome. J Res Med Sci. 2015;20:782-9. 2. Iglesias P, Selgas R, Romero S, Díez JJ. Selenium and kidney disease. J Nephrol. 2013;26(2):266-72. 3. Roman M, Jitaru P, Barbante C. Selenium biochemistry and its role for human health. Metallomics. 2014;6(1):25-54. 4. Wang X, Wu H, Long Z, Sun Q, Liu J, Liu Y, Hai C. Differential effect of Se on insulin resistance: regulation of adipogenesis and lipolysis. Molecular and Cellular Biochemistry. 2016;415:89-102. 5. Hurst R, Armah CN, Dainty JR, Hart DJ, Teucher B, Goldson AJ, et al. Establishing optimal selenium status: results of a randomized, double-blind, placebo-controlled trial. The American Journal of Clinical Nutrition. 2010;91(4):923-31. 6. Rayman MP. Food-chain selenium and human health: emphasis on intake. British Journal of Nutrition. 2008;100:254-68. 7. Rayman MP. Selenium and human health. Lancet. 2012;379:1256–68. 8. Bal C, Büyükşekerci M, Ercan M, Hocaoğlu A, Çelik HT, Abuşoğlu S, et al. Farklı selenyum seviyelerinin tiroid hormon sentezi üzerine etkisi. Turk Hij Den Biyol Derg. 2015;72(4):311-6. 9. Duntas LH, Benvenga S. Selenium: an element for life. Endocrine. 2015;48:756-75. 10. Xia Y, Hill KE, Li P, Xu J, Zhou D, Motley AK, et al. Optimization of selenoprotein P and other plasma selenium biomarkers for the assessment of the selenium nutritional requirement: a placebocontrolled, double-blind study of selenomethionine supplementation in selenium-deficient Chinese subjects. The American Journal of Clinical Nutrition. 2010;92(3):525-31.
Abstract
References
- 1. Tajaddini MH, Keikha M, Razzazzadeh A, Kelishadi R. A systematic review on the association of serum selenium and metabolic syndrome. J Res Med Sci. 2015;20:782-9. 2. Iglesias P, Selgas R, Romero S, Díez JJ. Selenium and kidney disease. J Nephrol. 2013;26(2):266-72. 3. Roman M, Jitaru P, Barbante C. Selenium biochemistry and its role for human health. Metallomics. 2014;6(1):25-54. 4. Wang X, Wu H, Long Z, Sun Q, Liu J, Liu Y, Hai C. Differential effect of Se on insulin resistance: regulation of adipogenesis and lipolysis. Molecular and Cellular Biochemistry. 2016;415:89-102. 5. Hurst R, Armah CN, Dainty JR, Hart DJ, Teucher B, Goldson AJ, et al. Establishing optimal selenium status: results of a randomized, double-blind, placebo-controlled trial. The American Journal of Clinical Nutrition. 2010;91(4):923-31. 6. Rayman MP. Food-chain selenium and human health: emphasis on intake. British Journal of Nutrition. 2008;100:254-68. 7. Rayman MP. Selenium and human health. Lancet. 2012;379:1256–68. 8. Bal C, Büyükşekerci M, Ercan M, Hocaoğlu A, Çelik HT, Abuşoğlu S, et al. Farklı selenyum seviyelerinin tiroid hormon sentezi üzerine etkisi. Turk Hij Den Biyol Derg. 2015;72(4):311-6. 9. Duntas LH, Benvenga S. Selenium: an element for life. Endocrine. 2015;48:756-75. 10. Xia Y, Hill KE, Li P, Xu J, Zhou D, Motley AK, et al. Optimization of selenoprotein P and other plasma selenium biomarkers for the assessment of the selenium nutritional requirement: a placebocontrolled, double-blind study of selenomethionine supplementation in selenium-deficient Chinese subjects. The American Journal of Clinical Nutrition. 2010;92(3):525-31.
Details
| Journal Section | Review |
|---|---|
| Authors | |
| Publication Date | December 13, 2017 |
| Published in Issue | Year 2017 Volume: 7 Issue: 4 |