Vitamin B12, Folate and Homocystein Status in Turkish Pregnant Women for each Trimester

Year 2019, Volume: 9 Issue: 2, 42 - 47, 28.06.2019

Pınar Calış Gizem Işık Deniz Karcaaltıncaba

Abstract

Objective: Vitamin B12 (cobalamin) and folate are essential micronutrient for cellular growth and
differentiation. In current sequential study, our aim is to determine the mean B12 and folate levels and
prevalence of B12 and folate deficiency at each trimester in Turkish healthy pregnant women who did not
use any supplementation.
Method: A prospective cross-sectional study was conducted between January-2016 and May-2017.
Singleton pregnancies in the first trimester, not using any vitamin supplementation were included. Blood
samples were collected at 10-14, 20-24 and at last 30-34 gestational weeks and vitamin B12, folate and
homocystein levels were calculated.
Results: In first trimester, we found out that 2.44%, in second trimester 2.41% and in third trimester 2.27%
of patients had vitamin B12 deficiency (B12<126.5 pg/mL). There was statistically significant decrease in
folate and homocystein levels in the second trimester compare to first trimester (p<0.001).
Conclusion: The homocysteine level was found similar in the third compared to first trimester with a gradual
increase from the second trimester value, this could be explained with the decrease in the B12 level in the
third trimester. By the way, deficiency rates for B12 and folate were rare in Turkey after new health policy
compared to other countries even without supplementation.

Keywords

Vitamin B12, Folate, Homocystein, Deficiency rate

TÜRK GEBE POPÜLASYONUNDA 1.2.3. TRİMESTER’DEKİ VIT B12, FOLAT VE HOMOSİSTEİN DÜZEYLERİNİN DEĞERLENDİRİLMESİ

Abstract

Amaç: Vitamin B12 ve folat, hücre büyümesi ve farklılaşması için esansiyel mikronutrientlerdir. Bu kesitsel
çalışmadaki amacımız, vitamin desteği almayan sağlıklı Türk gebe kadınlardaki vitamin B12 ve folat ortalamalarını ve eksiklik prevelanslarını tespit etmektir.
Method: Bu prospektif kesitsel çalışma Ocak 2016- Mayıs 2017 tarihleri arasında gerçekleşmiştir. Birinci
trimesterdeki, vitamin desteği almayan, tekil gebelikler çalışmaya dahil edilmiştir. 10-14, 20-24 ve son olarak 30-34 gestasyonel haftalarda kan örnekleri hastalardan toplanmış ve vitamin B12, folat ve homosistein
seviyeleri hesaplanmıştır.
Sonuç: Vitamin B12 eksikliği (B12<126.5 pg/mL), birinci trimesterde %2.44, ikinci trimesterde %2.41 ve
üçüncü trimesterde %2.27 gebede tespit edilmiştir. Folat ve homosistein seviyelerinde ikinci trimesterde ilk
trimestere göre istatistiki olarak anlamlı düşüş saptanmıştır (p<0.001).
Tartışma: Homosistein seviyesi üçüncü trimesterde ilk trimesterle benzer olmasına rağmen, ikinci trimester
göre hafif bir artış göstermiştir. Sonuç olarak, vitamin desteği bulunmamasına rağmen Türkiye’de yeni sağlık
sistemi politikası ile Vitamin B12 ve folat eksikliği diğer ülkeler ile kıyasla belirgin az olarak bulunmuştur.

Keywords

Vitamin B12, Folat, Homosistein, Eksiklik oranı

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