Case Report
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AKUT KORONER SENDROMLU HASTALARDA ÇOK DAMAR HASTALIĞI İLE KARDİYOVASKÜLER RİSK FAKTÖRLERİ ARASINDAKİ İLİŞKİ The Association Between Multivessel Disease and Cardiovascular Risk Factors in Patients with Acute Coronary Syndrome

Year 2019, Volume: 9 Issue: 4, 131 - 135, 27.12.2019

Abstract

ÖZET
Amaç: Akut koroner sendrom olgularında ciddi darlık olan koroner arter sayısı ile kardiyovasküler risk faktörleri
arasındaki ilişki değerlendirildi.
Yöntemler: Bu çalışma retrospektif olarak dizayn edildi. 2016–2018 tarihleri arasında akut koroner sendrom
sebebiyle koroner anjiografi yapılan 904 hasta çalışmaya dahil edildi. Ciddi koroner arter darlığı olmayan
ve koroner operasyon geçiren hastalar çalışma dışı bırakıldı. Hastalar kritik koroner arter darlıklarına göre
tek damar hastalığı (TDH) ve çok damar hastalığı (ÇDH) olacak şekilde iki gruba ayrıldı. ÇDH ile TDH olanlar
klasik kardiyovasküler risk faktörleri açısından karşılaştırıldı.
Bulgular: Hastaların 544’ünde (%60) ÇDH 365’inde (%40) TDH saptandı. ÇDH olan grupta yaş, hipertansiyon
ve diyabet mellitus istatistiksel olarak daha fazla saptandı (sırasıyla p<0.001, p=0.003, p=0.005). TDH
olan grupta ise erkek cinsiyet, aile öyküsü ve sigara içiciliği istatistiksel olarak daha fazla saptandı (sırasıyla
p=0.006, p<0.001, p<0.001).
Sonuç: Diyabet ve hipertansiyon ÇDH grubunda yüksek saptanırken aile öyküsü ve sigara içiciliği TDH grubunda
yüksek saptandı. Akut koroner sendrom hastalarında bu risk faktörlerin göz önünde bulundurulması
önemlidir.
Anahtar Kelimeler: Koroner arter hastalığı; Kardiyovasküler risk faktörleri; Koroner anjiografi
ABSTRACT
Aim: The relationship between the number of coronary arteries with severe stenosis and cardiovascular
risk factors was evaluated in patients with acute coronary syndrome.
Material-Method: This study was designed retrospectively. 904 patients who underwent coronary
angiography for acute coronary syndrome between 2016–2018 were included in the study. Patients who
underwent coronary bypass surgery and didn’t have severe coronary artery disease were excluded. The
patients were divided into two groups according to critical coronary artery stenosis as single vessel disease
and multiple vessel disease. The relationship between multivessel disease and risk factors was compared.
Results: Multivessel disease was detected in 544 (60%) patients and single vessel disease in 365 (40%)
patients. Age, hypertension and diabetes were found to be higher in multivessel disease (respectively
p<0.001, p=0.003, p=0.005). Male gender, family history and smoking were found to be higher in the single
vessel disease.
Conclusion: Diabetes and hypertension were higher in multivessel disease group, while family history and
smoking were higher in single vessel disease group. It is important to consider these risk factors in patients
with acute coronary syndrome.
Key Words: Coronary artery disease; Cardiovascular risk factors; Coronary angiography

References

  • 1. Onat A, Kaya A, Akbaş Şimşek T, Şimşek B, Tusun E, Karadeniz Y, et al. Twenty-five years of the TARF study: The 2015 survey, and temporal trends in mortality and loss to follow-up. Turk Kardiyol Dern Ars. 2016; 44(5):365-70. 2. Alpert JS, Thygesen K, Antman E, Bassand JP. Myocardial infarction redefined--a consensus document of The Joint European Society of Cardiology/American College of Cardiology Committee for the redefinition of myocardial infarction. J Am Coll Cardiol. 2000; 36(3):959-69. 3. Demir V, Yılmaz S, Ede H, Turan Y. Correlation of Resting Heart Rate with the Severity and Complexity of Coronary Artery Disease: A Single-Center Retrospective Study. Int J Prev Med. 2019; 7;10:104.4. Park DW, Clare RM, Schulte PJ, Pieper KS, Shaw LK, Califf RM, et al. Extent, location, and clinical significance of non-infarct-related coronary artery disease among patients with ST-elevation myocardial infarction. JAMA. 2014; 19;312(19):2019-27. 5. Fox K, GarciaMA, Ardissino D, Buszman P, Camici PG, Crea F, et al. Guidelines on the management of stable angina pectoris: executive summary: The Task Force on the Management of Stable Angina Pectoris of the European Society of Cardiology. Eur Heart J. 2006; 27:1341–81. 6. TEMD Obezite, Lipid Metabolizması, Hipertansiyon Çalışma Grubu. Obezite tanı ve tedavi kılavuzu, Türkiye Endokrinoloji ve Metabolizma Derneği 2017; 11-19. [İnternet: Türkiye Endokrinoloji ve Metabolizma Derneği]. Erişim: http://www.temd.org.tr/files/file/OBEZITE_TTK_web.pdf. 7. Demir V, Samet Y, Akboga MK. Association of lymphocyte-monocyte ratio and monocyte-to-high-density lipoprotein ratio with the presence and severity of rheumatic mitral valve stenosis. Biomark Med. 2017; 11(8):657-63. 8. Alp Ç, Dogru MT, Karadeniz M, Sarak T, Demir V, Çelik Y, et al. Serum pentraxin-3 levels and flow-mediated dilation in dipper and non-dipper hypertension. J Clin Lab Anal. 2019; 33(3):e22718. 9. Kumar A, Cannon CP. Acute coronary syndromes: diagnosis and management. Part I. Mayo Clin Proc. 2009; 84:917–38. 10. Ahmed MH, Awadalla H, Elmadhoun WM, Osman M, Noor SK, Almobarak AO. Prevalence and risk factors for acute coronary syndrome among sudanese individuals with diabetes: a population-based study. Cardiol Res. 2017; 8:184–9. 11. Larifla L, Armand C, Velayoudom-Cephise FL, Weladji G, Michel CT, Blanchet-Deverly A, et al. Distribution of coronary artery disease severity and risk factors in Afro-Caribbeans. Arch Cardiovasc Dis. 2014; 107(4):212-8. 12. Delp MD, Behnke BJ, Spier SA, Wu G, Muller-Delp JM. Ageing diminishes endothelium-dependent vasodilatation and tetrahydrobiopterin content in rat skeletal muscle arterioles. J Physiol. 2008; 15;586(4):1161-8. 13. Veeranna V, Pradhan J, Niraj A, Fakhry H, Afonso L. Traditional cardiovascular risk factors and severity of angiographic coronary artery disease in the elderly. Prev Cardiol. 2010;13(3):135-40. 14. Frei B, Forte TM, Ames BN, Cross CE. Gas phase oxidants of cigarette smoke induce lipid peroxidation and changes in lipoprotein properties in human blood plasma. Protective effects of ascorbic acid. Biochem J. 1991; 1;277 ( Pt 1):133-8. 15. Rival J, Riddle JM, Stein PD. Effects of chronic smoking on platelet function. Thromb Res. 1987; 45:75. 16. Haffner SM, Lehto S, Rönnemaa T, Pyörälä K, Laakso M. Mortality from coronary heart disease in subjects with type 2 diabetes and in nondiabetic subjects with and without prior myocardial infarction. N Engl J Med. 1998; 23;339(4):229-34. 17. Fuster V, Alexander RW O’Rourke R: Hurst’s The Heart. 10. Baskısının Türkçe çevirisi. And Danışmanlık Eğitim Yayıncılık ve Organizasyon Ltd. Şti.1. Basım. 2002; p. 1065-109.
Year 2019, Volume: 9 Issue: 4, 131 - 135, 27.12.2019

Abstract

References

  • 1. Onat A, Kaya A, Akbaş Şimşek T, Şimşek B, Tusun E, Karadeniz Y, et al. Twenty-five years of the TARF study: The 2015 survey, and temporal trends in mortality and loss to follow-up. Turk Kardiyol Dern Ars. 2016; 44(5):365-70. 2. Alpert JS, Thygesen K, Antman E, Bassand JP. Myocardial infarction redefined--a consensus document of The Joint European Society of Cardiology/American College of Cardiology Committee for the redefinition of myocardial infarction. J Am Coll Cardiol. 2000; 36(3):959-69. 3. Demir V, Yılmaz S, Ede H, Turan Y. Correlation of Resting Heart Rate with the Severity and Complexity of Coronary Artery Disease: A Single-Center Retrospective Study. Int J Prev Med. 2019; 7;10:104.4. Park DW, Clare RM, Schulte PJ, Pieper KS, Shaw LK, Califf RM, et al. Extent, location, and clinical significance of non-infarct-related coronary artery disease among patients with ST-elevation myocardial infarction. JAMA. 2014; 19;312(19):2019-27. 5. Fox K, GarciaMA, Ardissino D, Buszman P, Camici PG, Crea F, et al. Guidelines on the management of stable angina pectoris: executive summary: The Task Force on the Management of Stable Angina Pectoris of the European Society of Cardiology. Eur Heart J. 2006; 27:1341–81. 6. TEMD Obezite, Lipid Metabolizması, Hipertansiyon Çalışma Grubu. Obezite tanı ve tedavi kılavuzu, Türkiye Endokrinoloji ve Metabolizma Derneği 2017; 11-19. [İnternet: Türkiye Endokrinoloji ve Metabolizma Derneği]. Erişim: http://www.temd.org.tr/files/file/OBEZITE_TTK_web.pdf. 7. Demir V, Samet Y, Akboga MK. Association of lymphocyte-monocyte ratio and monocyte-to-high-density lipoprotein ratio with the presence and severity of rheumatic mitral valve stenosis. Biomark Med. 2017; 11(8):657-63. 8. Alp Ç, Dogru MT, Karadeniz M, Sarak T, Demir V, Çelik Y, et al. Serum pentraxin-3 levels and flow-mediated dilation in dipper and non-dipper hypertension. J Clin Lab Anal. 2019; 33(3):e22718. 9. Kumar A, Cannon CP. Acute coronary syndromes: diagnosis and management. Part I. Mayo Clin Proc. 2009; 84:917–38. 10. Ahmed MH, Awadalla H, Elmadhoun WM, Osman M, Noor SK, Almobarak AO. Prevalence and risk factors for acute coronary syndrome among sudanese individuals with diabetes: a population-based study. Cardiol Res. 2017; 8:184–9. 11. Larifla L, Armand C, Velayoudom-Cephise FL, Weladji G, Michel CT, Blanchet-Deverly A, et al. Distribution of coronary artery disease severity and risk factors in Afro-Caribbeans. Arch Cardiovasc Dis. 2014; 107(4):212-8. 12. Delp MD, Behnke BJ, Spier SA, Wu G, Muller-Delp JM. Ageing diminishes endothelium-dependent vasodilatation and tetrahydrobiopterin content in rat skeletal muscle arterioles. J Physiol. 2008; 15;586(4):1161-8. 13. Veeranna V, Pradhan J, Niraj A, Fakhry H, Afonso L. Traditional cardiovascular risk factors and severity of angiographic coronary artery disease in the elderly. Prev Cardiol. 2010;13(3):135-40. 14. Frei B, Forte TM, Ames BN, Cross CE. Gas phase oxidants of cigarette smoke induce lipid peroxidation and changes in lipoprotein properties in human blood plasma. Protective effects of ascorbic acid. Biochem J. 1991; 1;277 ( Pt 1):133-8. 15. Rival J, Riddle JM, Stein PD. Effects of chronic smoking on platelet function. Thromb Res. 1987; 45:75. 16. Haffner SM, Lehto S, Rönnemaa T, Pyörälä K, Laakso M. Mortality from coronary heart disease in subjects with type 2 diabetes and in nondiabetic subjects with and without prior myocardial infarction. N Engl J Med. 1998; 23;339(4):229-34. 17. Fuster V, Alexander RW O’Rourke R: Hurst’s The Heart. 10. Baskısının Türkçe çevirisi. And Danışmanlık Eğitim Yayıncılık ve Organizasyon Ltd. Şti.1. Basım. 2002; p. 1065-109.
There are 1 citations in total.

Details

Primary Language Turkish
Subjects Health Care Administration
Journal Section Case Report
Authors

Çağlar Alp

Muhammed Karadeniz This is me

Taner Sarak This is me

Vahit Demir This is me

Publication Date December 27, 2019
Published in Issue Year 2019 Volume: 9 Issue: 4

Cite

APA Alp, Ç., Karadeniz, M., Sarak, T., Demir, V. (2019). AKUT KORONER SENDROMLU HASTALARDA ÇOK DAMAR HASTALIĞI İLE KARDİYOVASKÜLER RİSK FAKTÖRLERİ ARASINDAKİ İLİŞKİ The Association Between Multivessel Disease and Cardiovascular Risk Factors in Patients with Acute Coronary Syndrome. Bozok Tıp Dergisi, 9(4), 131-135.
AMA Alp Ç, Karadeniz M, Sarak T, Demir V. AKUT KORONER SENDROMLU HASTALARDA ÇOK DAMAR HASTALIĞI İLE KARDİYOVASKÜLER RİSK FAKTÖRLERİ ARASINDAKİ İLİŞKİ The Association Between Multivessel Disease and Cardiovascular Risk Factors in Patients with Acute Coronary Syndrome. Bozok Tıp Dergisi. December 2019;9(4):131-135.
Chicago Alp, Çağlar, Muhammed Karadeniz, Taner Sarak, and Vahit Demir. “AKUT KORONER SENDROMLU HASTALARDA ÇOK DAMAR HASTALIĞI İLE KARDİYOVASKÜLER RİSK FAKTÖRLERİ ARASINDAKİ İLİŞKİ The Association Between Multivessel Disease and Cardiovascular Risk Factors in Patients With Acute Coronary Syndrome”. Bozok Tıp Dergisi 9, no. 4 (December 2019): 131-35.
EndNote Alp Ç, Karadeniz M, Sarak T, Demir V (December 1, 2019) AKUT KORONER SENDROMLU HASTALARDA ÇOK DAMAR HASTALIĞI İLE KARDİYOVASKÜLER RİSK FAKTÖRLERİ ARASINDAKİ İLİŞKİ The Association Between Multivessel Disease and Cardiovascular Risk Factors in Patients with Acute Coronary Syndrome. Bozok Tıp Dergisi 9 4 131–135.
IEEE Ç. Alp, M. Karadeniz, T. Sarak, and V. Demir, “AKUT KORONER SENDROMLU HASTALARDA ÇOK DAMAR HASTALIĞI İLE KARDİYOVASKÜLER RİSK FAKTÖRLERİ ARASINDAKİ İLİŞKİ The Association Between Multivessel Disease and Cardiovascular Risk Factors in Patients with Acute Coronary Syndrome”, Bozok Tıp Dergisi, vol. 9, no. 4, pp. 131–135, 2019.
ISNAD Alp, Çağlar et al. “AKUT KORONER SENDROMLU HASTALARDA ÇOK DAMAR HASTALIĞI İLE KARDİYOVASKÜLER RİSK FAKTÖRLERİ ARASINDAKİ İLİŞKİ The Association Between Multivessel Disease and Cardiovascular Risk Factors in Patients With Acute Coronary Syndrome”. Bozok Tıp Dergisi 9/4 (December 2019), 131-135.
JAMA Alp Ç, Karadeniz M, Sarak T, Demir V. AKUT KORONER SENDROMLU HASTALARDA ÇOK DAMAR HASTALIĞI İLE KARDİYOVASKÜLER RİSK FAKTÖRLERİ ARASINDAKİ İLİŞKİ The Association Between Multivessel Disease and Cardiovascular Risk Factors in Patients with Acute Coronary Syndrome. Bozok Tıp Dergisi. 2019;9:131–135.
MLA Alp, Çağlar et al. “AKUT KORONER SENDROMLU HASTALARDA ÇOK DAMAR HASTALIĞI İLE KARDİYOVASKÜLER RİSK FAKTÖRLERİ ARASINDAKİ İLİŞKİ The Association Between Multivessel Disease and Cardiovascular Risk Factors in Patients With Acute Coronary Syndrome”. Bozok Tıp Dergisi, vol. 9, no. 4, 2019, pp. 131-5.
Vancouver Alp Ç, Karadeniz M, Sarak T, Demir V. AKUT KORONER SENDROMLU HASTALARDA ÇOK DAMAR HASTALIĞI İLE KARDİYOVASKÜLER RİSK FAKTÖRLERİ ARASINDAKİ İLİŞKİ The Association Between Multivessel Disease and Cardiovascular Risk Factors in Patients with Acute Coronary Syndrome. Bozok Tıp Dergisi. 2019;9(4):131-5.
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