FOTOTERAPİ ALAN HASTALARDA DEMODEX FOLLİCULORUM VE DEMODEX BREVİS TÜRLERİNİN ARAŞTIRILMASI Investigation of Demodex folliculorum and Demodex brevis in Patients Undergoing Phototherapy
Abstract
ÖZET
Amaç: İnsanlarda Demodex folliculorum (DF) ve Demodex brevis (DB) olmak üzere sadece iki Demodex
türü saptanmıştır. Demodex akarları insan vücudunda en sık yüz bölgesinde (alın, yanak, burun ve çene)
bulunurken diğer bölgelerde daha seyrek yerleşirler. Çalışmada fototerapi tedavisi alarak immünsüpresyon
gelişen hastalarda Demodex akarlarının (DF ve DB) görülme sıklığının belirlenmesi amaçlanmıştır.
Gereç ve Yöntem: Çalışmaya dar bant ultraviyole B (UVB) fototerapisi alan 48 hasta ile yaş ve cinsiyet olarak
uyumlu 48 sağlıklı gönüllü kontrol grubu olarak dahil edildi. Katılan tüm bireylerin alın, sağ ve sol yanak, burun,
çene ve sırt bölgesinden standart yüzeyel deri biyopsisi tekniği (SYDB) ile örnekler alınarak ışık mikroskobunda
incelendi. Tanıda cm²'de 5 veya daha fazla akar görülmesi pozitif olarak değerlendirildi.
Bulgular: Fototerapi alan hastaların kontrol grubuna göre daha fazla Demodex akarı ile enfeste olduğu görüldü
(p=0.001). Dar bant UVB fototerapisi alan 48 hastanın 14'ünde DF, 8 hastada DF'ye ek olarak DB'nin pozitif
olduğu belirlendi. Kontrol grubunda ise sadece 1 kişide DF pozitifliği mevcut olup DB tespit edilmedi. Demodex
spp. görülme durumu fototerapi alan grupta kontrol grubuna göre istatistiksel olarak anlamlı bulundu (p<0.05).
Sonuç: Bu çalışmada fototerapinin Demodex akar yoğunluğunu önemli derecede arttırdığı belirlendi. Bu
nedenle, fototerapi alan hastalarda immün sistemin zayıflaması sonucu demodikozise bağlı cilt lezyonlarının
gelişebileceği akılda tutulmalıdır.
Anahtar Sözcükler: Fototerapi; Demodex akarları; Demodex folliculorum; Demodex brevis; İmmünsüpresyon.
ABSTRACT
Objectives: There have been only two species of Demodex identified in humans, namely, Demodex folliculorum
(DF) and Demodex brevis (DB). While Demodex [Acari: Demodicidae] are mostly located in humans on facial
parts including the forehead, cheeks, nose and chin, they occur more sparsely in other areas. The aim of this
study was to establish the prevalence of Demodex in immunosuppressed patients undergoing phototherapy.
Materials and Methods: The study involved 48 patients receiving narrow‐band ultraviolet B (NB-UVB)
phototherapy in addition to 48 healthy volunteers of comparable age and gender as the control group.
Specimens were taken from all participants by using standardized skin-surface biopsy of the forehead, right
and left cheeks, nose, chin and back proximal areas and were inspected with a light microscope. The incidence
of 5 or more mites per cm² was assessed as positive in the diagnosis.
Results: The patients receiving phototherapy were seen to have been more infested with Demodex mites than
the control group (p=0.001). Out of 48 patients treated with NB-UVB therapy, 14 were tested positive for DF
while 8 patients had positive DB apart from DF. As for the control group, only 1 participant had positive DF
while DB was not observed. The incidence of DF infestation was statistically rather significant in the treatment
group receiving phototherapy when compared with the control group (p>0.05).
Conclusion: In this study, it was found that phototherapy increased the Demodex density. Therefore, it should
be remembered that Demodex spp. will increase with the weakening of the immune system and it may cause
skin lesions in patients treated with phototherapy.
Keywords: Phototherapy; Demodex mites; Demodex folliculorum; Demodex brevis; Immunosuppression.
References
- 1. Baima B, Sticherling M. Demodicidosis revisited. Acta Derm Venereol. 2002;82:3-6. 2. Forton FMN. Papulopustular rosacea, skin immunity and Demodex: pityriasis folliculorum as a missing link. J Eur Acad Dermatol Venerol. 2012;26:19-28. 3.Hsu CK, Hsu MM, Lee JY. Demodicosis: a clinicopathological study. J Am Acad Dermatol. 2009;60:453-62. 4. Lacey N, Ní Raghallaigh S, Powell FC. Demodex mites-- commensals, parasites or mutualistic organisms? Dermatology. 2011;222:128-30. 5. Rusiecka-Ziolkowska J, Nokiel M, Fleischer M. Demodex-an old pathogen or a new one? Adv Clin Exp Med. 2014; 23(2):295-8. 6. Sönmez OU, Yalçın ZG, Karakece E, Ciftci IH, Erdem T. Associations between Demodex species infestation and various types of cancer. Acta Parasitol. 2013;58:551-5. 7. İnci M, Kaya ÖA, İnci M, Yula E, Gökçe H, Rifaioğlu MM. ve ark. Ürolojik kanserli hastalarda Demodex folliculorum araştırılması. Turkiye Parazitol Derg. 2012;36:208-10. 8. Ivy SP, Mackall CL, Gore L, Gress RE, Hartley AH. Demodicidosis in childhood acute lymphoblastic leukemia; an opportunistic infection occurring with immunosuppression. J Pediatr. 1995;127:751-4. 9. Aquilina C, Viraben R, Sire S. Ivermectin-responsive Demodex infestation during human immunodeficiency virus infection. A case report and literature review. Dermatology. 2002;205:394-7. 10. Dominey A, Rosen T, Tschen J. Papulonodular demodicidosis associated with acquired immunodeficiency syndrome. J Am Acad Dermatol. 1989;20:197-201.
Abstract
References
- 1. Baima B, Sticherling M. Demodicidosis revisited. Acta Derm Venereol. 2002;82:3-6. 2. Forton FMN. Papulopustular rosacea, skin immunity and Demodex: pityriasis folliculorum as a missing link. J Eur Acad Dermatol Venerol. 2012;26:19-28. 3.Hsu CK, Hsu MM, Lee JY. Demodicosis: a clinicopathological study. J Am Acad Dermatol. 2009;60:453-62. 4. Lacey N, Ní Raghallaigh S, Powell FC. Demodex mites-- commensals, parasites or mutualistic organisms? Dermatology. 2011;222:128-30. 5. Rusiecka-Ziolkowska J, Nokiel M, Fleischer M. Demodex-an old pathogen or a new one? Adv Clin Exp Med. 2014; 23(2):295-8. 6. Sönmez OU, Yalçın ZG, Karakece E, Ciftci IH, Erdem T. Associations between Demodex species infestation and various types of cancer. Acta Parasitol. 2013;58:551-5. 7. İnci M, Kaya ÖA, İnci M, Yula E, Gökçe H, Rifaioğlu MM. ve ark. Ürolojik kanserli hastalarda Demodex folliculorum araştırılması. Turkiye Parazitol Derg. 2012;36:208-10. 8. Ivy SP, Mackall CL, Gore L, Gress RE, Hartley AH. Demodicidosis in childhood acute lymphoblastic leukemia; an opportunistic infection occurring with immunosuppression. J Pediatr. 1995;127:751-4. 9. Aquilina C, Viraben R, Sire S. Ivermectin-responsive Demodex infestation during human immunodeficiency virus infection. A case report and literature review. Dermatology. 2002;205:394-7. 10. Dominey A, Rosen T, Tschen J. Papulonodular demodicidosis associated with acquired immunodeficiency syndrome. J Am Acad Dermatol. 1989;20:197-201.
Details
| Primary Language | Turkish |
|---|---|
| Subjects | Health Care Administration |
| Journal Section | Original Research |
| Authors | |
| Publication Date | June 8, 2020 |
| Published in Issue | Year 2020 Volume: 10 Issue: 2 |