DİZ OSTEOARTRİT HASTALARINDA SERUM SALUSİN- ΑLFA VE SALUSİN-ΒETA DÜZEYLERİ Serum Salusin-Αlpha and Salusin-Βeta Levels in Patients with Knee Osteoarthritis
Abstract
ÖZET
Giriş: Osteoartrit (OA), yaşlılarda yüksek prevalanslı majör kas-iskelet sistemi hastalığıdır. Eklem kıkırdağının
ağrılı kaybı ile karakterize, poligenik ve çok faktörlüdür. Çalışmamızda diz osteoartrit hastalarında serum
salusin-α ve salusin-β seviyelerini araştırmayı amaçladık.
Gereç ve Yöntemler: Serum örnekleri 38 sağlıklı ve 35 diz osteoartritli bireylerden elde edilmiştir. Serum
örneklerinde ELISA yöntemi ile salusin-α ve salusin-β seviyeleri belirlenmiştir.
Bulgular: Serum salusin-α seviyesi OA grubunda (2569±839 pg/ml), kontrol grubuna (3131±1066 pg/ml)
kıyasla anlamlı olarak azalmıştır (p=0.0136). Benzer şekilde serum salusin-β seviyesi de OA grubunda (708±207
pg/ml) kontrol grubuna (1027±448 pg/ml) oranla düşük olarak bulunmuştur (p=0.0002).
Sonuç: Serum salusin-α ve salusin-β düzeyleri birbirleriyle korele şekilde diz osteoartritli hastalarda azalmıştır.
Diz OA hastalığında serum seviyesi düşük olan salusinlerin hangi moleküler mekanizmalar üzerinden OA
hastalığı ile ilişkili olduğunun anlaşılması için daha ileri araştırmalara ihtiyaç duyulmaktadır.
Anahtar Kelimeler: Osteoartrit; salusin-α; salusin-β ; serum; ELISA
ABSTRACT
Aim: Osteoarthritis (OA) is a major musculoskeletal disease with high prevalence in the elderly. It is
characterised by the painful loss of articular cartilage and is polygenic and multifactorial. In this study, we
aimed to investigate serum salusin-α and salusin-β levels in patients with knee osteoarthritis.
Materials and Methods: Serum samples were obtained from 38 healthy subjects and 35 knee osteoarthrit
patients. Salusin-α and salusin-β levels were determined by ELISA in serum samples.
Results: Serum salusin-α levels were significantly decreased in the OA group (2569±839 pg/ml) compared to
the control group (3131±1066 pg/ml) (p=0.0136). Similarly, serum salusin-β levels were lower in OA group
(708±207 pg/ml) than in control group (1027±448 pg/ml) (p=0.0002).
Conclusion: Serum salusin-α and salusin-β levels decreased in patients with knee osteoarthritis, correlated
with each other. Further investigations are needed to understand the molecular mechanisms associated with
low serum levels of salusins in knee OA.
Keywords: Osteoarthrit; salusin-α; salusin-β ; serum; ELISA
References
- 1. Abramson, S.B., et al., Nitric oxide and inflammatory mediators in the perpetuation of osteoarthritis. Curr Rheumatol Rep, 2001. 3(6): p. 535-41. 2. Peat, G., R. McCarney, and P. Croft, Knee pain and osteoarthritis in older adults: a review of community burden and current use of primary health care. Ann Rheum Dis, 2001. 60(2): p. 91-7. 3. Kraus, V.B., et al., Call for standardized definitions of osteoarthritis and risk stratification for clinical trials and clinical use. Osteoarthritis Cartilage, 2015. 23(8): p. 1233-41. 4. Li, D., G. Xie, and W. Wang, Reactive oxygen species: the 2-edged sword of osteoarthritis. Am J Med Sci, 2012. 344(6): p. 486-90. 5. Henrotin, Y., B. Kurz, and T. Aigner, Oxygen and reactive oxygen species in cartilage degradation: friends or foes? Osteoarthritis Cartilage, 2005. 13(8): p. 643-54. 6. Shichiri, M., et al., Salusins: newly identified bioactive peptides with hemodynamic and mitogenic activities. Nat Med, 2003. 9(9): p. 1166-72. 7. Yu, F., et al., Salusins promote cardiomyocyte growth but does not affect cardiac function in rats. Regul Pept, 2004. 122(3): p. 191-7. 8. Xiao-Hong, Y., et al., Salusins protect neonatal rat cardiomyocytes from serum deprivation-induced cell death through upregulation of GRP78. J Cardiovasc Pharmacol, 2006. 48(2): p. 41-6. 9. Cakir, M., et al., Protective effects of salusin-alpha and salusin-beta on renal ischemia/reperfusion damage and their levels in ischemic acute renal failure. Biotech Histochem, 2017. 92(2): p. 122-133. 10. Citil, C., et al., Brain, liver, and serum salusin-alpha and -beta alterations in Sprague-Dawley rats with or without metabolic synSABAH ÖZCAN ve ark. Osteoartritte Serum Salusin Seviyeleri Bozok Tıp Derg 2020;10(2):184-88 Bozok Med J 2020;10(2):184-88 188 drome. Med Sci Monit, 2014. 20: p. 1326-33.
Abstract
References
- 1. Abramson, S.B., et al., Nitric oxide and inflammatory mediators in the perpetuation of osteoarthritis. Curr Rheumatol Rep, 2001. 3(6): p. 535-41. 2. Peat, G., R. McCarney, and P. Croft, Knee pain and osteoarthritis in older adults: a review of community burden and current use of primary health care. Ann Rheum Dis, 2001. 60(2): p. 91-7. 3. Kraus, V.B., et al., Call for standardized definitions of osteoarthritis and risk stratification for clinical trials and clinical use. Osteoarthritis Cartilage, 2015. 23(8): p. 1233-41. 4. Li, D., G. Xie, and W. Wang, Reactive oxygen species: the 2-edged sword of osteoarthritis. Am J Med Sci, 2012. 344(6): p. 486-90. 5. Henrotin, Y., B. Kurz, and T. Aigner, Oxygen and reactive oxygen species in cartilage degradation: friends or foes? Osteoarthritis Cartilage, 2005. 13(8): p. 643-54. 6. Shichiri, M., et al., Salusins: newly identified bioactive peptides with hemodynamic and mitogenic activities. Nat Med, 2003. 9(9): p. 1166-72. 7. Yu, F., et al., Salusins promote cardiomyocyte growth but does not affect cardiac function in rats. Regul Pept, 2004. 122(3): p. 191-7. 8. Xiao-Hong, Y., et al., Salusins protect neonatal rat cardiomyocytes from serum deprivation-induced cell death through upregulation of GRP78. J Cardiovasc Pharmacol, 2006. 48(2): p. 41-6. 9. Cakir, M., et al., Protective effects of salusin-alpha and salusin-beta on renal ischemia/reperfusion damage and their levels in ischemic acute renal failure. Biotech Histochem, 2017. 92(2): p. 122-133. 10. Citil, C., et al., Brain, liver, and serum salusin-alpha and -beta alterations in Sprague-Dawley rats with or without metabolic synSABAH ÖZCAN ve ark. Osteoartritte Serum Salusin Seviyeleri Bozok Tıp Derg 2020;10(2):184-88 Bozok Med J 2020;10(2):184-88 188 drome. Med Sci Monit, 2014. 20: p. 1326-33.
Details
| Primary Language | Turkish |
|---|---|
| Subjects | Health Care Administration |
| Journal Section | Original Research |
| Authors | |
| Publication Date | June 8, 2020 |
| Published in Issue | Year 2020 Volume: 10 Issue: 2 |