ASSOCIATION BETWEEN THE STAGE OF DIABETIC RETINOPATHY AND THIOL/DISULFIDE HOMEOSTASIS Diyabetik Retinopati Evresi ile Tiyol/Disülfid Homeostazı Arasındaki İlişki

Year 2024, Volume: 14 Issue: 1, 40 - 43, 15.03.2024

Mehmet Coşkun , İsmail Haskul , Salim Neşelioğlu , Özcan Erel

Abstract

Objective: This study investigate the association between the stage of retinopathy and thiol/disulfide homeostasis
in patients with type 2 diabetes.
Material and Methods: Group 1, 100 diabetic patients without retinopathy; Group 2, 115 patients with nonproliferative
diabetic retinopathy(NPDR); and Group 3, 72 patients with proliferative diabetic retinopathy(
PDR). Disulfide, native thiol levels (NTLs) and total thiol levels(TTLs), disulfide/NT ratio (index 1), disulfide/
TT ratio (index 2) and NT/TT ratio (index 3) of the patients were evaluated. Patients were excluded if
they had cardiovascular or cerebrovascular diseases, or a diagnosis of inflammatory diseases or malignancy,
if they were using any medications including lipid lowering agents, vitamins, or any antioxidants, or if they
had a history of alcohol intake or smoking.
Results: There was no significant difference between the groups in terms of age and gender (p=0.098 and
p=0.16, respectively). No significant difference was observed between the groups with respect to disulfide
levels (p=0.22). NTLs and TTLs were lowest in Group 1 and highest in Group 3. Significant differences
were found in NTLs and TTLs between all groups (for NTLs, p=0.01, p=0.001 and p=0.001, respectively; for
TTLs, p=0.008, p=0.001 and p=0.006, respectively). Index 1, 2 and 3 values were not significantly different
between Group 1 and 2 (p=0.83, p=0.43 and p=0.43, respectively), while significant differences were observed
between Group 1 and 3 and between Group 2 and 3 (for all 3 indexes, p=0.001)
Conclusion: While there was no difference between the groups in terms of disulfide levels, NTL and TTL
were found to be lower as the retinopathy stage increased.

Keywords

ASSOCIATION BETWEEN THE STAGE OF DIABETIC, RETINOPATHY AND THIOL/DISULFIDE HOMEOSTASIS, Diyabetik Retinopati Evresi ile Tiyol/Disülfid Homeostazı Arasındaki İlişki

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