THE RELATIONSHIP BETWEEN TOCILIZUMAB USE AND EOSINOPHIL COUNT IN PATIENTS WITH RHEUMATOID ARTHRITIS: A RETROSPECTIVE STUDY Romatoid Artritli Hastalarda Tosilizumab Kullanımı ile Eozinofil Sayısı Arasındaki İlişki: Retrospektif Bir Çalışma

Year 2024, Volume: 14 Issue: 4, 215 - 220, 15.12.2024

Elem Yorulmaz , Duygu Geler Külcü

Abstract

ABSTRACT
Objective: This study aimed to determine the relationship between tosilizumab use and eosinophil counts
in patients with rheumatoid arthritis.
Material and Methods: Thirty five patients diagnosed with rheumatoid arthritis (RA) receiving either synthetic
disease-modifying antirheumatic drugs (DMARDs) or tocilizumab treatment were included in this
study. Patient age and disease duration, disease activity parameters and eosinophil values were recorded.
Results: Comparing the eosinophil counts and percentages of the DMARD group with the Tocilizumab
group, any statistically significant differences were found. There was no significant difference in eosinophil
counts and percentages in the DMARD group in repeated measurements. However, in the Tocilizumab
group, there was a significant difference in both parameters.
Conclusion: A significant increase in eosinophil counts was observed in the group receiving tocilizumab
therapy at the 1st month. Therefore, during treatment monitoring, especially in the early stages, attention
should also be paid to eosinophil values.

Keywords

THE RELATIONSHIP BETWEEN TOCILIZUMAB USE AND EOSINOPHIL COUNT IN PATIENTS WITH RHEUMATOID, ARTHRITIS: A RETROSPECTIVE STUDY, Romatoid Artritli Hastalarda Tosilizumab Kullanımı ile Eozinofil Sayısı Arasındaki İlişki: Retrospektif Bir Çalışma

THE RELATIONSHIP BETWEEN TOCILIZUMAB USE AND EOSINOPHIL COUNT IN PATIENTS WITH RHEUMATOID ARTHRITIS: A RETROSPECTIVE STUDY Romatoid Artritli Hastalarda Tosilizumab Kullanımı ile Eozinofil Sayısı Arasındaki İlişki: Retrospektif Bir Çalışma

Abstract

Objective: This study aimed to determine the relationship between tosilizumab use and eosinophil counts
in patients with rheumatoid arthritis.
Material and Methods: Thirty five patients diagnosed with rheumatoid arthritis (RA) receiving either synthetic
disease-modifying antirheumatic drugs (DMARDs) or tocilizumab treatment were included in this
study. Patient age and disease duration, disease activity parameters and eosinophil values were recorded.
Results: Comparing the eosinophil counts and percentages of the DMARD group with the Tocilizumab
group, any statistically significant differences were found. There was no significant difference in eosinophil
counts and percentages in the DMARD group in repeated measurements. However, in the Tocilizumab
group, there was a significant difference in both parameters.
Conclusion: A significant increase in eosinophil counts was observed in the group receiving tocilizumab
therapy at the 1st month. Therefore, during treatment monitoring, especially in the early stages, attention
should also be paid to eosinophil values.

Keywords

THE RELATIONSHIP BETWEEN TOCILIZUMAB USE AND EOSINOPHIL COUNT IN PATIENTS WITH RHEUMATOID ARTHRITIS: A RETROSPECTIVE STUDY, Romatoid Artritli Hastalarda Tosilizumab Kullanımı ile Eozinofil Sayısı Arasındaki İlişki: Retrospektif Bir Çalışma, THE RELATIONSHIP BETWEEN TOCILIZUMAB USE AND EOSINOPHIL COUNT IN PATIENTS WITH RHEUMATOID

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