CLINICAL SIGNIFICANCE OF ALBUMIN/GLOBULIN RATIO FOR SURVIVAL PREDICTION IN ISCHEMIC STROKE PATIENTS IN INTENSIVE CARE Yoğun Bakımdaki İskemik İnme Hastalarında Sağ Kalım Tahmini İçin Albumin/Globulin Oranının Klinik Önemi

Year 2024, Volume: 14 Issue: 4, 269 - 277, 15.12.2024

Hikmet Saçmacı , Tülin Aktürk , Halil Önder

Abstract

ABSTRACT
Objective: Decreased level of serum albumin is shown to be associated with an increased risk of mortality
after stroke. However, the significance of the albumin/globulin ratio (AGR) as a paraclinical marker in determination
of the prognosis of stroke is unclear. In this study, we aimed to examine the potential utility of
AGR in determination of the need of intensive care unit monitorization and prognosis of patients with acute
stroke.
Material and Methods: Sequential samples of all the patients with acute ischemic stroke (AIS) who were
hospitalized between 2018 and 2022 in the mentioned centers were analyzed in this research. The data
regarding the demographic features, stroke subtypes, and laboratory findings including hemogram, and biochemistry
were recorded. AGR, serum osmolality, and colloid osmotic pressure (COP) were also measured.
The survival curves of the patients were constructed using the Kaplan-Meier methods and log-rank tests.
Estimates of survival changes were made by applying the Cox regression analysis.
Results: Ultimately, the data of 328 patients were analyzed. Thirty nine (30.2%) had passed away before
discharge. There were significant differences between the deceased patients and patients surviving in terms
of stroke classification, serum albumin, AGR, CRP, COP, and white blood cell count (p < 0.05). Serum AGR
of 94 patients who were intensive care unit patients showed a statistical difference compared to albumin
(p < 0.05). The Cox’s regression analyses showed that low AGR moderately predicted the mortality of patients.
Conclusion: We found that the AGR provided important data regarding the necessity of critical care monitorization
and prognosis of patients with AIS. Our findings support the potential utility of AGR as a simple, and
useful paralinical laboratory marker in patients with AIS.

Keywords

CLINICAL SIGNIFICANCE OF ALBUMIN/GLOBULIN RATIO FOR SURVIVAL PREDICTION IN ISCHEMIC STROKE PATIENTS IN INTENSIVE CARE, Yoğun Bakımdaki İskemik İnme Hastalarında Sağ Kalım Tahmini İçin Albumin/Globulin Oranının Klinik Önemi, CLINICAL SIGNIFICANCE OF ALBUMIN/GLOBULIN RATIO

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