Research Article
BibTex RIS Cite

KÖPEKLERDE ATOPİK DERMATİTİS, LEİSHMANİAZİS VE DEMODİKOZİSTE KLİNİK SKORLAMALARIN ARAŞTIRILMASI

Year 2024, , 62 - 68, 31.12.2024
https://doi.org/10.58833/bozokvetsci.1548515

Abstract

Bu çalışmada, klinik demodikozis, kanin viseral leishmaniasis (KVL) ve atopik dermatitli (Ad) köpeklerde dermatolojik klinik skorlamaların uygulanması ve hastalık prognozuna olan etkisi incelendi. Farklı ırk, yaş ve cinsiyetteki 26 köpek (5 demodikozis, 12 CVL, 9 Ad) değerlendirildi. Her hastalık grubunda kabul görmüş klinik skorlamalar kullanılarak, rutin değerlendirmeler kapsamında hematolojik ve biyokimyasal analizler, deri kazıntısı, hızlı testler ve sitolojik incelemeler yapıldı. Ad’ li köpeklerde en yoğun lezyonlar aksilla ve abdominal bölgede, KVL’li köpeklerde ise en sık lenfadenomegali ve onikogrifozis gözlemlendi. Demodikozisli köpeklerde ise en şiddetli lezyonlar arka bacaklar ve boyun bölgesinde tespit edildi. Çalışmada, veteriner hekimlerin dermatolojik klinik skorlamalar ile hastalığın seyrini ve tedaviye yanıtı objektif olarak değerlendirebileceği ve bu sayede etkili tedavi stratejileri geliştirebileceği sonucuna ulaşıldı.

Ethical Statement

Bu çalışma Aydın Adnan Menderes Üniversitesi Hayvan Deneyleri Yerel Etik Kurulu'nun (HADYEK) 64583101/134 onay numarası ile gerçekleştirilmiştir.

Supporting Institution

Aydın Adnan Menderes Üniversitesi Bilimsel Araştırma Projeleri Birimi -VTF - 23021

Project Number

VTF-23021

Thanks

-

References

  • 1. Dos Santos Nogueira F, Avino VC, Galvis-Ovallos F, Pereira-Chioccola VL, Moreira MAB, et al. Use of miltefosine to treat canine visceral leishmaniasis caused by Leishmania infantum in Brazil. Parasites & Vectors, 2015, 12, 1-11.
  • 2. Dengler B, Mendoza‐Kuznetsova E, Nikolaeva L, Rieger A, Mueller RS. Evaluation Of A Clinical Scoring System For Canine Demodicosis. Veterinary Dermatology, 2021, 32(4), 311-E84.
  • 3. Cugmas B, Olivry T. Evaluation of skin erythema severity by dermatoscopy in dogs with atopic dermatitis. Veterinary Dermatology, 2021, 32(2), 183-e46.
  • 4. Szczepanik M, Wilkołek P, Gołyński M, Sitkowski W, Taszkun I, Toczek W. The influence of treatment with lokivetmab on transepidermal water loss (TEWL) in dogs with spontaneously occurring atopic dermatitis. Veterinary Dermatology, 2019, 30(4), 330-e93.
  • 5. Baneth G, Nachum-Biala Y, Shabat Simon M, Brenner O, Gaier S, et al. Leishmania major infection in a dog with cutaneous manifestations. Parasites & Vectors, 2016, 9, 1-5.
  • 6. Solano-Gallego L, Koutinas A, Miró G, Cardoso L, Pennisi MG, et al. Directions for the diagnosis, clinical staging, treatment and prevention of canine leishmaniosis. Veterinary Parasitology, 2009, 165(1-2), 1-18.
  • 7. Reis AB, Martins-Filho OA, Teixeira-Carvalho A, Giunchetti RC, Carneiro CM, et al. Systemic and compartmentalized immune response in canine visceral leishmaniasis. Veterinary Immunology and Immunopathology, 2009, 128(1-3), 87-95.
  • 8. Meléndez-Lazo A, Ordeix L, Planellas M, Pastor J, Solano-Gallego L. Clinicopathological findings in sick dogs naturally infected with Leishmania infantum: Comparison of five different clinical classification systems. Research in Veterinary Science, 2018, 117, 18-27.
  • 9. Miro G, Cardoso L, Pennisi MG, Oliva G, Baneth G. Canine leishmaniosis–new concepts and insights on an expanding zoonosis: part two. Trends in Parasitology, 2008, 24(8), 371-377.
  • 10. Medkour H, Laidoudi Y, Lafri I, Davoust B, Mekroud A, et al. Canine vector-borne protozoa: Molecular and serological investigation for Leishmania spp., Trypanosoma spp., Babesia spp., and Hepatozoon spp. in dogs from Northern Algeria. Veterinary Parasitology: Regional Studies and Reports, 2020, 19, 100353.
  • 11. Halliwell R. Revised nomenclature for veterinary allergy. Veterinary Immunology and Immunopathology, 2006, 114(3-4), 207-208.
  • 12. Pucheu‐Haston CM, Bizikova P, Eisenschenk MN, Santoro D, Nuttall T, Marsella R. The role of antibodies, autoantigens and food allergens in canine atopic dermatitis. Veterinary Dermatology, 2015, 26(2), 115-e30.
  • 13. Bizikova P, Santoro D, Marsella R, Nuttall T, Eisenschenk MN, Pucheu‐Haston CM. Clinical and histological manifestations of canine atopic dermatitis. Veterinary Dermatology, 2015, 26(2), 79-e24.
  • 14. Favrot C, Steffan J, Seewald W, Picco F. A prospective study on the clinical features of chronic canine atopic dermatitis and its diagnosis. Veterinary Dermatology, 2010, 21, 23–31.
  • 15. Wilhem S, Kovalik M, Favrot C. Breed-associated phenotypes in canine atopic dermatitis. Veterinary Dermatology, 2011, 22, 143–9.
  • 16. Olivry T, Saridomichelakis M, Nuttall T, Bensignor E, Griffin CE, Hill PB. International Committee on Allergic Diseases of Animals (ICADA). Validation of the Canine Atopic Dermatitis Extent and Severity Index (CADESI)-4, a simplified severity scale for assessing skin lesions of atopic dermatitis in dogs. Veterinary Dermatology, 2014, 25(2), 77-85.
  • 17. Mueller RS, Rosenkrantz W, Bensignor E, Karaś-Tęcza J, Paterson T, Shipstone MA. WAVD Clinical consensus guidelines for demodicosis. 2018.
  • 18. Rahman M, Bostami MB, Datta A, Sabuj AAM, Rana EA, et al. Estimation of the prevalence and determination of risk factors associated with demodicosis in dogs. Journal of Advanced Veterinary and Animal Research, 2021, 8(1), 116.
  • 19. Gartner A, Dărăbuș G, Badea C, Hora F, Tilibasa E, Mederle N. Clinical diagnosis in canine demodicosis. A new approach. Scientific Works. Series C. Veterinary Medicine, 2015, LXI (2), 76-80.
  • 20. Gortel K. Update on canine demodicosis. Veterinary Clinics: Small Animal Practice, 2006, 36(1), 229-241.
  • 21. Plant JD, Gortel K, Kovalik M, Polissar NL, Neradilek MB. Development and validation of the Canine Atopic Dermatitis Lesion Index, a scale for the rapid scoring of lesion severity in canine atopic dermatitis. Veterinary Dermatology, 2012, 23, 515–e103.
  • 22. Manna L, Reale S, Vitale F, Gravino AE. Evidence for a relationship between Leishmania load and clinical manifestations. Research in Veterinary Science, 2009, 87(1), 76-78.
  • 23. Silva KRD, Mendonça VRRD, Silva KM, Nascimento LFMD, Mendes-Sousa AF, et al. Scoring clinical signs can help diagnose canine visceral leishmaniasis in a highly endemic area in Brazil. Memórias do Instituto Oswaldo Cruz, 2017, 112(1), 53-63.
  • 24. Beugnet F, Halos L, Larsen D. Efficacy of oral afoxolaner for the treatment of canine generalised demodicosis. Parasite, 2016, 23(14),1-8.
  • 25. Lebon W, Beccati M, Bourdeau P, Brement T, Bruet V, et al. Efficacy of two formulations of afoxolaner (NexGard® and NexGard Spectra®) for the treatment of generalised demodicosis in dogs, in veterinary dermatology referral centers in Europe. Parasites & Vectors, 2018, 11, 1-10.
  • 26. Zanette MF, Lima VF, Laurenti MD, Rossi CN, Vides JP, Vieira RFC. Serological cross-reactivity of Trypanosoma cruzi, Ehrlichia canis, Toxoplasma gondii, Neospora caninum and Babesia canis to Leishmania infantum chagasi tests in dogs. Revista da Sociedada Brasileria de Medicana Tropical, 2014, 47, 105-107.

INVESTIGATION OF CLINICAL SCORING IN DOGS WITH ATOPIC DERMATITIS, LEISHMANIASIS, AND DEMODICOSIS

Year 2024, , 62 - 68, 31.12.2024
https://doi.org/10.58833/bozokvetsci.1548515

Abstract

This study investigates the application of dermatological clinical scoring in dogs with clinical demodicosis, canine visceral leishmaniasis (CVL), and atopic dermatitis (Ad), and its impact on disease prognosis. Twenty-six dogs of different breeds, ages, and genders (5 with demodicosis, 12 with CVL, and 9 with Ad) were evaluated. Accepted clinical scoring systems were used in each group, and routine evaluations included hematological and biochemical analyses, microscopic examination of skin scrapings, rapid tests, and cytological examinations. In dogs with Ad, the most intense lesions were observed in the axillary and abdominal regions, while lymphadenopathy and onychogryphosis were the most common findings in dogs with CVL. In dogs with demodicosis, the most severe lesions were found on the hind limbs and neck. This study concludes that veterinarians can use dermatological clinical scoring to objectively assess disease progression and response to treatment, thereby developing more effective treatment strategies.

Project Number

VTF-23021

References

  • 1. Dos Santos Nogueira F, Avino VC, Galvis-Ovallos F, Pereira-Chioccola VL, Moreira MAB, et al. Use of miltefosine to treat canine visceral leishmaniasis caused by Leishmania infantum in Brazil. Parasites & Vectors, 2015, 12, 1-11.
  • 2. Dengler B, Mendoza‐Kuznetsova E, Nikolaeva L, Rieger A, Mueller RS. Evaluation Of A Clinical Scoring System For Canine Demodicosis. Veterinary Dermatology, 2021, 32(4), 311-E84.
  • 3. Cugmas B, Olivry T. Evaluation of skin erythema severity by dermatoscopy in dogs with atopic dermatitis. Veterinary Dermatology, 2021, 32(2), 183-e46.
  • 4. Szczepanik M, Wilkołek P, Gołyński M, Sitkowski W, Taszkun I, Toczek W. The influence of treatment with lokivetmab on transepidermal water loss (TEWL) in dogs with spontaneously occurring atopic dermatitis. Veterinary Dermatology, 2019, 30(4), 330-e93.
  • 5. Baneth G, Nachum-Biala Y, Shabat Simon M, Brenner O, Gaier S, et al. Leishmania major infection in a dog with cutaneous manifestations. Parasites & Vectors, 2016, 9, 1-5.
  • 6. Solano-Gallego L, Koutinas A, Miró G, Cardoso L, Pennisi MG, et al. Directions for the diagnosis, clinical staging, treatment and prevention of canine leishmaniosis. Veterinary Parasitology, 2009, 165(1-2), 1-18.
  • 7. Reis AB, Martins-Filho OA, Teixeira-Carvalho A, Giunchetti RC, Carneiro CM, et al. Systemic and compartmentalized immune response in canine visceral leishmaniasis. Veterinary Immunology and Immunopathology, 2009, 128(1-3), 87-95.
  • 8. Meléndez-Lazo A, Ordeix L, Planellas M, Pastor J, Solano-Gallego L. Clinicopathological findings in sick dogs naturally infected with Leishmania infantum: Comparison of five different clinical classification systems. Research in Veterinary Science, 2018, 117, 18-27.
  • 9. Miro G, Cardoso L, Pennisi MG, Oliva G, Baneth G. Canine leishmaniosis–new concepts and insights on an expanding zoonosis: part two. Trends in Parasitology, 2008, 24(8), 371-377.
  • 10. Medkour H, Laidoudi Y, Lafri I, Davoust B, Mekroud A, et al. Canine vector-borne protozoa: Molecular and serological investigation for Leishmania spp., Trypanosoma spp., Babesia spp., and Hepatozoon spp. in dogs from Northern Algeria. Veterinary Parasitology: Regional Studies and Reports, 2020, 19, 100353.
  • 11. Halliwell R. Revised nomenclature for veterinary allergy. Veterinary Immunology and Immunopathology, 2006, 114(3-4), 207-208.
  • 12. Pucheu‐Haston CM, Bizikova P, Eisenschenk MN, Santoro D, Nuttall T, Marsella R. The role of antibodies, autoantigens and food allergens in canine atopic dermatitis. Veterinary Dermatology, 2015, 26(2), 115-e30.
  • 13. Bizikova P, Santoro D, Marsella R, Nuttall T, Eisenschenk MN, Pucheu‐Haston CM. Clinical and histological manifestations of canine atopic dermatitis. Veterinary Dermatology, 2015, 26(2), 79-e24.
  • 14. Favrot C, Steffan J, Seewald W, Picco F. A prospective study on the clinical features of chronic canine atopic dermatitis and its diagnosis. Veterinary Dermatology, 2010, 21, 23–31.
  • 15. Wilhem S, Kovalik M, Favrot C. Breed-associated phenotypes in canine atopic dermatitis. Veterinary Dermatology, 2011, 22, 143–9.
  • 16. Olivry T, Saridomichelakis M, Nuttall T, Bensignor E, Griffin CE, Hill PB. International Committee on Allergic Diseases of Animals (ICADA). Validation of the Canine Atopic Dermatitis Extent and Severity Index (CADESI)-4, a simplified severity scale for assessing skin lesions of atopic dermatitis in dogs. Veterinary Dermatology, 2014, 25(2), 77-85.
  • 17. Mueller RS, Rosenkrantz W, Bensignor E, Karaś-Tęcza J, Paterson T, Shipstone MA. WAVD Clinical consensus guidelines for demodicosis. 2018.
  • 18. Rahman M, Bostami MB, Datta A, Sabuj AAM, Rana EA, et al. Estimation of the prevalence and determination of risk factors associated with demodicosis in dogs. Journal of Advanced Veterinary and Animal Research, 2021, 8(1), 116.
  • 19. Gartner A, Dărăbuș G, Badea C, Hora F, Tilibasa E, Mederle N. Clinical diagnosis in canine demodicosis. A new approach. Scientific Works. Series C. Veterinary Medicine, 2015, LXI (2), 76-80.
  • 20. Gortel K. Update on canine demodicosis. Veterinary Clinics: Small Animal Practice, 2006, 36(1), 229-241.
  • 21. Plant JD, Gortel K, Kovalik M, Polissar NL, Neradilek MB. Development and validation of the Canine Atopic Dermatitis Lesion Index, a scale for the rapid scoring of lesion severity in canine atopic dermatitis. Veterinary Dermatology, 2012, 23, 515–e103.
  • 22. Manna L, Reale S, Vitale F, Gravino AE. Evidence for a relationship between Leishmania load and clinical manifestations. Research in Veterinary Science, 2009, 87(1), 76-78.
  • 23. Silva KRD, Mendonça VRRD, Silva KM, Nascimento LFMD, Mendes-Sousa AF, et al. Scoring clinical signs can help diagnose canine visceral leishmaniasis in a highly endemic area in Brazil. Memórias do Instituto Oswaldo Cruz, 2017, 112(1), 53-63.
  • 24. Beugnet F, Halos L, Larsen D. Efficacy of oral afoxolaner for the treatment of canine generalised demodicosis. Parasite, 2016, 23(14),1-8.
  • 25. Lebon W, Beccati M, Bourdeau P, Brement T, Bruet V, et al. Efficacy of two formulations of afoxolaner (NexGard® and NexGard Spectra®) for the treatment of generalised demodicosis in dogs, in veterinary dermatology referral centers in Europe. Parasites & Vectors, 2018, 11, 1-10.
  • 26. Zanette MF, Lima VF, Laurenti MD, Rossi CN, Vides JP, Vieira RFC. Serological cross-reactivity of Trypanosoma cruzi, Ehrlichia canis, Toxoplasma gondii, Neospora caninum and Babesia canis to Leishmania infantum chagasi tests in dogs. Revista da Sociedada Brasileria de Medicana Tropical, 2014, 47, 105-107.
There are 26 citations in total.

Details

Primary Language Turkish
Subjects Veterinary Internal Medicine
Journal Section Research Articles
Authors

Kerem Ural 0000-0003-1867-7143

Selahattin Karaoğlu 0009-0008-2490-4043

Project Number VTF-23021
Publication Date December 31, 2024
Submission Date September 12, 2024
Acceptance Date October 25, 2024
Published in Issue Year 2024

Cite

Vancouver Ural K, Karaoğlu S. KÖPEKLERDE ATOPİK DERMATİTİS, LEİSHMANİAZİS VE DEMODİKOZİSTE KLİNİK SKORLAMALARIN ARAŞTIRILMASI. Bozok Vet Sci. 2024;5(2):62-8.