Elektrokemoterapi ve Veteriner Hekimlikte Kullanım Alanları

Year 2022, Volume: 3 Issue: 1, 5 - 11, 30.06.2022

Ülfet Tandoğan Duygu Tarhan Banu Dokuzeylül Alev Meltem Ercan M. Erman Or

Abstract

Elektrokemoterapi, doksanlı yılların başından itibaren beşeri hekimlikte kullanılmaya başlanan, son yıllarda da veteriner hekimlikte kullanılan önemli ve yeni bir lokal antitümöral tedavi yöntemidir. Elektroporasyon ile kemoterapinin birleşimi, hem kemoterapinin yüksek düzeydeki yan etkilerini minimuma indirmiş hem de elektroporasyon sayesinde, kullanılan kemoterapötik ilaçların sitotoksik etkinliğini maksimum seviyede tutmayı başarmıştır. Elektrokemoterapi uygulamaları 2006 yılından itibaren hem beşeri hekimlikte hem de veteriner hekimlikte Avrupa standartlarında belirlenmiş prosedürlere göre uygulanmaktadır. Veteriner hekimlikte elektrokemoterapi kedi, köpek, at ve son yıllarda egzotik hayvanlarda özellikle kutanöz tümörlerin tedavisinde kullanım alanı bulmuştur. Bu derlemenin amacı, elektrokemoterapinin çalışma mekanizmasını ve veteriner hekimlikte yer bulan uygulamalarını sunarak bu yeni teknik hakkında genel bir bilgi oluşmasına yardımcı olmaktır.

Keywords

Elektrokemoterapi, elektroporasyon, veteriner hekimlik

Electrochemotherapy and Areas of Usage In Veterinary Medicine

Abstract

Electrochemotherapy is an important and new local antitumoral treatment method that has been used in human medicine since the beginning of the nineties and has been used in veterinary medicine in recent years. The combination of electroporation and chemotherapy both minimized the high-level side effects of chemotherapy and managed to keep the cytotoxic efficiency of the chemotherapeutic drugs used at the maximum level. Electrochemotherapy applications have been applied in both human medicine and veterinary medicine according to the procedures of European standards since 2006. In veterinary medicine, electrochemotherapy has been used in the treatment of cutaneous tumors in cats, dogs, horses and in recent years, exotic animals. The aim of this review is to give information about this new technique by presenting the working mechanism of electrochemotherapy and its applications in veterinary medicine.

Keywords

Electrochemotherapy, electroporation, veterinary medicine

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