Year 2024,
Volume: 7 Issue: 1, 1 - 16, 31.12.2024
Gökçe Nur Devrim
,
Azra Yıldırım
,
Selina Türkmen
,
Yeşim Ateş
,
Sude Yamaç
,
Murat Ihlamur
Abstract
The anal region, which is the end of the digestive system, has a complex anatomical arrangement. Surgeons interested in the anal region need to have the best knowledge about the anatomy of this region and the types of anal cancer that occur. Although anal cancers are rare, they are common, especially among young men. The reason for the increase in the rate of anal cancer is due to the increase in HPV and the high survival rate of individuals with HIV infection. In this study, the reasons why anal cancer occurs, how its formation is detected, what types of anal cancer are, how many stages it is divided into, macroscopic diagnosis of its stages, what kind of findings it contains as well as tumors, and the treatment processes of cancer are discussed.
References
- Aigner, F., & Siegel, R. (2023). [Diagnostics, treatment and aftercare of anal cancer]. Chirurgie (Heidelb), 94(10), 890-898. doi:10.1007/s00104-023-01849-2
- Al Hallak, M. N., & Zouain, N. (2009). Extramammary Perianal Paget's Disease. Case Rep Gastroenterol, 3(3), 332-337. doi:10.1159/000256382
- Cacheux, W., Lievre, A., De La Rochefordiere, A., Dieumegard, B., Cvitkovic, F., Labib, A., & Buecher, B. (2012). Chemotherapy in the treatment of anal canal carcinoma. Dig Liver Dis, 44(10), 803-811. doi:10.1016/j.dld.2012.04.013
- Chumbalkar, V., Jennings, T. A., Ainechi, S., Lee, E. C., & Lee, H. (2016). Extramammary Paget's Disease of Anal Canal Associated With Rectal Adenoma Without Invasive Carcinoma. Gastroenterology Res, 9(6), 99-102. doi:10.14740/gr727e
- Ciombor, K. K., Ernst, R. D., & Brown, G. (2017). Diagnosis and Diagnostic Imaging of Anal Canal Cancer. Surg Oncol Clin N Am, 26(1), 45-55. doi:10.1016/j.soc.2016.07.002
- Cleary, R. K., Schaldenbrand, J. D., Fowler, J. J., Schuler, J. M., & Lampman, R. M. (1999). Perianal Bowen's disease and anal intraepithelial neoplasia: review of the literature. Dis Colon Rectum, 42(7), 945-951. doi:10.1007/bf02237107
- Dandapani, S. V., Eaton, M., Thomas, C. R., Jr., & Pagnini, P. G. (2010). HIV- positive anal cancer: an update for the clinician. J Gastrointest Oncol, 1(1), 34-44. doi:10.3978/j.issn.2078-6891.2010.005
- Dee, E. C., Byrne, J. D., & Wo, J. Y. (2021). Evolution of the Role of Radiotherapy for Anal Cancer. Cancers (Basel), 13(6). doi:10.3390/cancers13061208
- Gami, B., Kubba, F., & Ziprin, P. (2014). Human papilloma virus and squamous cell carcinoma of the anus. Clin Med Insights Oncol, 8, 113-119. doi:10.4137/cmo.S13241
- Gilshtein, H., & Khoury, W. (2015). Surgical management of anal cancer. Minerva Chir, 70(2), 141-145.
- Gondal, T. A., Chaudhary, N., Bajwa, H., Rauf, A., Le, D., & Ahmed, S. (2023). Anal Cancer: The Past, Present and Future. Curr Oncol, 30(3), 3232-3250. doi:10.3390/curroncol30030246
- Grulich, A. E., Poynten, I. M., Machalek, D. A., Jin, F., Templeton, D. J., & Hillman, R. J. (2012). The epidemiology of anal cancer. Sex Health, 9(6), 504-508. doi:10.1071/sh12070
- Hoedema, R. E. (2018). Anal Intraepithelial Neoplasia and Squamous Cell Cancer of the Anus. Clin Colon Rectal Surg, 31(6), 347-352. doi:10.1055/s-0038-1668104
- Jácome, A. A., Morris, V. K., & Eng, C. (2022). The Role of Immunotherapy in the Treatment of Anal Cancer and Future Strategies. Curr Treat Options Oncol, 23(8), 1073-1085. doi:10.1007/s11864-022-00939-3
- Khandwala, P., Singhal, S., Desai, D., Parsi, M., & Potdar, R. (2021). HIV-Associated Anal Cancer. Cureus, 13(5), e14834. doi:10.7759/cureus.14834
- Leonard, D., Beddy, D., & Dozois, E. J. (2011). Neoplasms of anal canal and perianal skin. Clin Colon Rectal Surg, 24(1), 54-63. doi:10.1055/s-0031-1272824
- Maas, M., Tielbeek, J. A. W., & Stoker, J. (2020). Staging of Anal Cancer: Role of MR Imaging. Magn Reson Imaging Clin N Am, 28(1), 127-140. doi:10.1016/j.mric.2019.09.005
- Malaguarnera, G., Madeddu, R., Catania, V. E., Bertino, G., Morelli, L., Perrotta, R. E., & Latteri, S. (2018). Anorectal mucosal melanoma. Oncotarget, 9(9), 8785-8800. doi:10.18632/oncotarget.23835
- Morton, M., Melnitchouk, N., & Bleday, R. (2018). Squamous cell carcinoma of the anal canal. Curr Probl Cancer, 42(5), 486-492. doi:10.1016/j.currproblcancer.2018.11.001
- Palaniappan, V., & Karthikeyan, K. (2022). Bowen's Disease. Indian Dermatol Online J, 13(2), 177-189. doi:10.4103/idoj.idoj_257_21
- Pawlowski, J., & Jones, I. W. (2024). Radiation Therapy for Anal Cancer. In StatPearls. Treasure Island (FL) ineligible companies. Disclosure: William Jones III declares no relevant financial relationships with ineligible companies.: StatPearls Publishing Copyright © 2024, StatPearls Publishing LLC.
- Pessia, B., Romano, L., Giuliani, A., Lazzarin, G., Carlei, F., & Schietroma, M. (2020). Squamous cell anal cancer: Management and therapeutic options. Ann Med Surg (Lond), 55, 36-46. doi:10.1016/j.amsu.2020.04.016
- Phuong, L., & Rajdev, L. (2020). Immunotherapy in Anal Cancer. Curr Oncol Rep, 22(9), 94. doi:10.1007/s11912-020-00946-3
- Pineda, C. E., & Welton, M. L. (2009). Management of anal squamous intraepithelial lesions. Clin Colon Rectal Surg, 22(2), 94-101. doi:10.1055/s-0029-1223840
- Roberts, J. R., Siekas, L. L., & Kaz, A. M. (2017). Anal intraepithelial neoplasia: A review of diagnosis and management. World J Gastrointest Oncol, 9(2), 50-61. doi:10.4251/wjgo.v9.i2.50
- Row, D., & Weiser, M. R. (2009). Anorectal melanoma. Clin Colon Rectal Surg, 22(2), 120-126. doi:10.1055/s-0029-1223844
- Rüschoff, J., Aust, A., Middel, P., & Heinmöller, E. (2011). [Anal cancer: diagnostic and differential diagnostic issues]. Pathologe, 32(4), 336-344. doi:10.1007/s00292-011-1440-4
- Sauter, M., Keilholz, G., Kranzbühler, H., Lombriser, N., Prakash, M., Vavricka, S. R., & Misselwitz, B. (2016). Presenting symptoms predict local staging of anal cancer: a retrospective analysis of 86 patients. BMC Gastroenterol, 16, 46. doi:10.1186/s12876-016-0461-0
- Shenoy, S., Nittala, M., & Assaf, Y. (2019). Anal carcinoma in giant anal condyloma, multidisciplinary approach necessary for optimal outcome: Two case reports and review of literature. World J Gastrointest Oncol, 11(2), 172-180. doi:10.4251/wjgo.v11.i2.172
- Siddharthan, R. V., Lanciault, C., & Tsikitis, V. L. (2019). Anal intraepithelial neoplasia: diagnosis, screening, and treatment. Ann Gastroenterol, 32(3), 257-263. doi:10.20524/aog.2019.0364
- Siegel, R. L., Miller, K. D., Wagle, N. S., & Jemal, A. (2023). Cancer statistics, 2023. CA Cancer J Clin, 73(1), 17-48. doi:10.3322/caac.21763
- Surabhi, V. R., Menias, C. O., Amer, A. M., Elshikh, M., Katabathina, V. S., Hara, A. K., & Siegel, C. L. (2016). Tumors and Tumorlike Conditions of the Anal Canal and Perianal Region: MR Imaging Findings. Radiographics, 36(5), 1339-1353. doi:10.1148/rg.2016150209
- Tchelebi, L. T., Eng, C., Messick, C. A., Hong, T. S., Ludmir, E. B., Kachnic, L. A., & Zaorsky, N. G. (2022). Current treatment and future directions in the management of anal cancer. CA Cancer J Clin, 72(2), 183-195. doi:10.3322/caac.21712
- Uronis, H. E., & Bendell, J. C. (2007). Anal cancer: an overview. Oncologist, 12(5), 524-534. doi:10.1634/theoncologist.12-5-524
- Young, A. N., Jacob, E., Willauer, P., Smucker, L., Monzon, R., & Oceguera, L. (2020). Anal Cancer. Surg Clin North Am, 100(3), 629-634.
Anal Kanserlere Genel Bakış
Year 2024,
Volume: 7 Issue: 1, 1 - 16, 31.12.2024
Gökçe Nur Devrim
,
Azra Yıldırım
,
Selina Türkmen
,
Yeşim Ateş
,
Sude Yamaç
,
Murat Ihlamur
Abstract
Sindirim sisteminin bitişi olan anal bölge karmaşık bir anatomik düzene sahiptir. Anal bölgeyle ilgilenen cerrahların bu bölgenin anatomisi ve gerçekleşen anal kanser biçimleriyle ilgili en iyi şekilde bilgi sahibi olmaları gerekir. Anal kanserler nadir olsa da özellikle genç erkekler arasında yaygın olmaktadır. Anal kanser oranının artışının nedeni HPV artışı ve HIV enfeksiyonlu bireylerin yaşam oranlarının yüksekliğinden kaynaklanmaktadır. Bu çalışmada anal kanserin hangi sebeplerle oluştuğu, oluşumunu nasıl tespit edildiği, anal kanserin hangi türlerinin olduğu, kaç evreye ayrıldığı ve evrelerinin makroskobik tanıları, tümörlerin yanı sıra ayrıca ne tür bulgular içerdiği ve kanserin tedavi süreçlerine değinilmiştir.
References
- Aigner, F., & Siegel, R. (2023). [Diagnostics, treatment and aftercare of anal cancer]. Chirurgie (Heidelb), 94(10), 890-898. doi:10.1007/s00104-023-01849-2
- Al Hallak, M. N., & Zouain, N. (2009). Extramammary Perianal Paget's Disease. Case Rep Gastroenterol, 3(3), 332-337. doi:10.1159/000256382
- Cacheux, W., Lievre, A., De La Rochefordiere, A., Dieumegard, B., Cvitkovic, F., Labib, A., & Buecher, B. (2012). Chemotherapy in the treatment of anal canal carcinoma. Dig Liver Dis, 44(10), 803-811. doi:10.1016/j.dld.2012.04.013
- Chumbalkar, V., Jennings, T. A., Ainechi, S., Lee, E. C., & Lee, H. (2016). Extramammary Paget's Disease of Anal Canal Associated With Rectal Adenoma Without Invasive Carcinoma. Gastroenterology Res, 9(6), 99-102. doi:10.14740/gr727e
- Ciombor, K. K., Ernst, R. D., & Brown, G. (2017). Diagnosis and Diagnostic Imaging of Anal Canal Cancer. Surg Oncol Clin N Am, 26(1), 45-55. doi:10.1016/j.soc.2016.07.002
- Cleary, R. K., Schaldenbrand, J. D., Fowler, J. J., Schuler, J. M., & Lampman, R. M. (1999). Perianal Bowen's disease and anal intraepithelial neoplasia: review of the literature. Dis Colon Rectum, 42(7), 945-951. doi:10.1007/bf02237107
- Dandapani, S. V., Eaton, M., Thomas, C. R., Jr., & Pagnini, P. G. (2010). HIV- positive anal cancer: an update for the clinician. J Gastrointest Oncol, 1(1), 34-44. doi:10.3978/j.issn.2078-6891.2010.005
- Dee, E. C., Byrne, J. D., & Wo, J. Y. (2021). Evolution of the Role of Radiotherapy for Anal Cancer. Cancers (Basel), 13(6). doi:10.3390/cancers13061208
- Gami, B., Kubba, F., & Ziprin, P. (2014). Human papilloma virus and squamous cell carcinoma of the anus. Clin Med Insights Oncol, 8, 113-119. doi:10.4137/cmo.S13241
- Gilshtein, H., & Khoury, W. (2015). Surgical management of anal cancer. Minerva Chir, 70(2), 141-145.
- Gondal, T. A., Chaudhary, N., Bajwa, H., Rauf, A., Le, D., & Ahmed, S. (2023). Anal Cancer: The Past, Present and Future. Curr Oncol, 30(3), 3232-3250. doi:10.3390/curroncol30030246
- Grulich, A. E., Poynten, I. M., Machalek, D. A., Jin, F., Templeton, D. J., & Hillman, R. J. (2012). The epidemiology of anal cancer. Sex Health, 9(6), 504-508. doi:10.1071/sh12070
- Hoedema, R. E. (2018). Anal Intraepithelial Neoplasia and Squamous Cell Cancer of the Anus. Clin Colon Rectal Surg, 31(6), 347-352. doi:10.1055/s-0038-1668104
- Jácome, A. A., Morris, V. K., & Eng, C. (2022). The Role of Immunotherapy in the Treatment of Anal Cancer and Future Strategies. Curr Treat Options Oncol, 23(8), 1073-1085. doi:10.1007/s11864-022-00939-3
- Khandwala, P., Singhal, S., Desai, D., Parsi, M., & Potdar, R. (2021). HIV-Associated Anal Cancer. Cureus, 13(5), e14834. doi:10.7759/cureus.14834
- Leonard, D., Beddy, D., & Dozois, E. J. (2011). Neoplasms of anal canal and perianal skin. Clin Colon Rectal Surg, 24(1), 54-63. doi:10.1055/s-0031-1272824
- Maas, M., Tielbeek, J. A. W., & Stoker, J. (2020). Staging of Anal Cancer: Role of MR Imaging. Magn Reson Imaging Clin N Am, 28(1), 127-140. doi:10.1016/j.mric.2019.09.005
- Malaguarnera, G., Madeddu, R., Catania, V. E., Bertino, G., Morelli, L., Perrotta, R. E., & Latteri, S. (2018). Anorectal mucosal melanoma. Oncotarget, 9(9), 8785-8800. doi:10.18632/oncotarget.23835
- Morton, M., Melnitchouk, N., & Bleday, R. (2018). Squamous cell carcinoma of the anal canal. Curr Probl Cancer, 42(5), 486-492. doi:10.1016/j.currproblcancer.2018.11.001
- Palaniappan, V., & Karthikeyan, K. (2022). Bowen's Disease. Indian Dermatol Online J, 13(2), 177-189. doi:10.4103/idoj.idoj_257_21
- Pawlowski, J., & Jones, I. W. (2024). Radiation Therapy for Anal Cancer. In StatPearls. Treasure Island (FL) ineligible companies. Disclosure: William Jones III declares no relevant financial relationships with ineligible companies.: StatPearls Publishing Copyright © 2024, StatPearls Publishing LLC.
- Pessia, B., Romano, L., Giuliani, A., Lazzarin, G., Carlei, F., & Schietroma, M. (2020). Squamous cell anal cancer: Management and therapeutic options. Ann Med Surg (Lond), 55, 36-46. doi:10.1016/j.amsu.2020.04.016
- Phuong, L., & Rajdev, L. (2020). Immunotherapy in Anal Cancer. Curr Oncol Rep, 22(9), 94. doi:10.1007/s11912-020-00946-3
- Pineda, C. E., & Welton, M. L. (2009). Management of anal squamous intraepithelial lesions. Clin Colon Rectal Surg, 22(2), 94-101. doi:10.1055/s-0029-1223840
- Roberts, J. R., Siekas, L. L., & Kaz, A. M. (2017). Anal intraepithelial neoplasia: A review of diagnosis and management. World J Gastrointest Oncol, 9(2), 50-61. doi:10.4251/wjgo.v9.i2.50
- Row, D., & Weiser, M. R. (2009). Anorectal melanoma. Clin Colon Rectal Surg, 22(2), 120-126. doi:10.1055/s-0029-1223844
- Rüschoff, J., Aust, A., Middel, P., & Heinmöller, E. (2011). [Anal cancer: diagnostic and differential diagnostic issues]. Pathologe, 32(4), 336-344. doi:10.1007/s00292-011-1440-4
- Sauter, M., Keilholz, G., Kranzbühler, H., Lombriser, N., Prakash, M., Vavricka, S. R., & Misselwitz, B. (2016). Presenting symptoms predict local staging of anal cancer: a retrospective analysis of 86 patients. BMC Gastroenterol, 16, 46. doi:10.1186/s12876-016-0461-0
- Shenoy, S., Nittala, M., & Assaf, Y. (2019). Anal carcinoma in giant anal condyloma, multidisciplinary approach necessary for optimal outcome: Two case reports and review of literature. World J Gastrointest Oncol, 11(2), 172-180. doi:10.4251/wjgo.v11.i2.172
- Siddharthan, R. V., Lanciault, C., & Tsikitis, V. L. (2019). Anal intraepithelial neoplasia: diagnosis, screening, and treatment. Ann Gastroenterol, 32(3), 257-263. doi:10.20524/aog.2019.0364
- Siegel, R. L., Miller, K. D., Wagle, N. S., & Jemal, A. (2023). Cancer statistics, 2023. CA Cancer J Clin, 73(1), 17-48. doi:10.3322/caac.21763
- Surabhi, V. R., Menias, C. O., Amer, A. M., Elshikh, M., Katabathina, V. S., Hara, A. K., & Siegel, C. L. (2016). Tumors and Tumorlike Conditions of the Anal Canal and Perianal Region: MR Imaging Findings. Radiographics, 36(5), 1339-1353. doi:10.1148/rg.2016150209
- Tchelebi, L. T., Eng, C., Messick, C. A., Hong, T. S., Ludmir, E. B., Kachnic, L. A., & Zaorsky, N. G. (2022). Current treatment and future directions in the management of anal cancer. CA Cancer J Clin, 72(2), 183-195. doi:10.3322/caac.21712
- Uronis, H. E., & Bendell, J. C. (2007). Anal cancer: an overview. Oncologist, 12(5), 524-534. doi:10.1634/theoncologist.12-5-524
- Young, A. N., Jacob, E., Willauer, P., Smucker, L., Monzon, R., & Oceguera, L. (2020). Anal Cancer. Surg Clin North Am, 100(3), 629-634.