Sindirim sisteminin bitişi olan anal bölge karmaşık bir anatomik düzene sahiptir. Anal bölgeyle ilgilenen cerrahların bu bölgenin anatomisi ve gerçekleşen anal kanser biçimleriyle ilgili en iyi şekilde bilgi sahibi olmaları gerekir. Anal kanserler nadir olsa da özellikle genç erkekler arasında yaygın olmaktadır. Anal kanser oranının artışının nedeni HPV artışı ve HIV enfeksiyonlu bireylerin yaşam oranlarının yüksekliğinden kaynaklanmaktadır. Bu çalışmada anal kanserin hangi sebeplerle oluştuğu, oluşumunu nasıl tespit edildiği, anal kanserin hangi türlerinin olduğu, kaç evreye ayrıldığı ve evrelerinin makroskobik tanıları, tümörlerin yanı sıra ayrıca ne tür bulgular içerdiği ve kanserin tedavi süreçlerine değinilmiştir.
Aigner, F., & Siegel, R. (2023). [Diagnostics, treatment and aftercare of anal cancer]. Chirurgie (Heidelb), 94(10), 890-898. doi:10.1007/s00104-023-01849-2
Al Hallak, M. N., & Zouain, N. (2009). Extramammary Perianal Paget's Disease. Case Rep Gastroenterol, 3(3), 332-337. doi:10.1159/000256382
Cacheux, W., Lievre, A., De La Rochefordiere, A., Dieumegard, B., Cvitkovic, F., Labib, A., & Buecher, B. (2012). Chemotherapy in the treatment of anal canal carcinoma. Dig Liver Dis, 44(10), 803-811. doi:10.1016/j.dld.2012.04.013
Chumbalkar, V., Jennings, T. A., Ainechi, S., Lee, E. C., & Lee, H. (2016). Extramammary Paget's Disease of Anal Canal Associated With Rectal Adenoma Without Invasive Carcinoma. Gastroenterology Res, 9(6), 99-102. doi:10.14740/gr727e
Ciombor, K. K., Ernst, R. D., & Brown, G. (2017). Diagnosis and Diagnostic Imaging of Anal Canal Cancer. Surg Oncol Clin N Am, 26(1), 45-55. doi:10.1016/j.soc.2016.07.002
Cleary, R. K., Schaldenbrand, J. D., Fowler, J. J., Schuler, J. M., & Lampman, R. M. (1999). Perianal Bowen's disease and anal intraepithelial neoplasia: review of the literature. Dis Colon Rectum, 42(7), 945-951. doi:10.1007/bf02237107
Dandapani, S. V., Eaton, M., Thomas, C. R., Jr., & Pagnini, P. G. (2010). HIV- positive anal cancer: an update for the clinician. J Gastrointest Oncol, 1(1), 34-44. doi:10.3978/j.issn.2078-6891.2010.005
Dee, E. C., Byrne, J. D., & Wo, J. Y. (2021). Evolution of the Role of Radiotherapy for Anal Cancer. Cancers (Basel), 13(6). doi:10.3390/cancers13061208
Gami, B., Kubba, F., & Ziprin, P. (2014). Human papilloma virus and squamous cell carcinoma of the anus. Clin Med Insights Oncol, 8, 113-119. doi:10.4137/cmo.S13241
Gilshtein, H., & Khoury, W. (2015). Surgical management of anal cancer. Minerva Chir, 70(2), 141-145.
Gondal, T. A., Chaudhary, N., Bajwa, H., Rauf, A., Le, D., & Ahmed, S. (2023). Anal Cancer: The Past, Present and Future. Curr Oncol, 30(3), 3232-3250. doi:10.3390/curroncol30030246
Grulich, A. E., Poynten, I. M., Machalek, D. A., Jin, F., Templeton, D. J., & Hillman, R. J. (2012). The epidemiology of anal cancer. Sex Health, 9(6), 504-508. doi:10.1071/sh12070
Hoedema, R. E. (2018). Anal Intraepithelial Neoplasia and Squamous Cell Cancer of the Anus. Clin Colon Rectal Surg, 31(6), 347-352. doi:10.1055/s-0038-1668104
Jácome, A. A., Morris, V. K., & Eng, C. (2022). The Role of Immunotherapy in the Treatment of Anal Cancer and Future Strategies. Curr Treat Options Oncol, 23(8), 1073-1085. doi:10.1007/s11864-022-00939-3
Khandwala, P., Singhal, S., Desai, D., Parsi, M., & Potdar, R. (2021). HIV-Associated Anal Cancer. Cureus, 13(5), e14834. doi:10.7759/cureus.14834
Leonard, D., Beddy, D., & Dozois, E. J. (2011). Neoplasms of anal canal and perianal skin. Clin Colon Rectal Surg, 24(1), 54-63. doi:10.1055/s-0031-1272824
Maas, M., Tielbeek, J. A. W., & Stoker, J. (2020). Staging of Anal Cancer: Role of MR Imaging. Magn Reson Imaging Clin N Am, 28(1), 127-140. doi:10.1016/j.mric.2019.09.005
Malaguarnera, G., Madeddu, R., Catania, V. E., Bertino, G., Morelli, L., Perrotta, R. E., & Latteri, S. (2018). Anorectal mucosal melanoma. Oncotarget, 9(9), 8785-8800. doi:10.18632/oncotarget.23835
Morton, M., Melnitchouk, N., & Bleday, R. (2018). Squamous cell carcinoma of the anal canal. Curr Probl Cancer, 42(5), 486-492. doi:10.1016/j.currproblcancer.2018.11.001
Palaniappan, V., & Karthikeyan, K. (2022). Bowen's Disease. Indian Dermatol Online J, 13(2), 177-189. doi:10.4103/idoj.idoj_257_21
Pessia, B., Romano, L., Giuliani, A., Lazzarin, G., Carlei, F., & Schietroma, M. (2020). Squamous cell anal cancer: Management and therapeutic options. Ann Med Surg (Lond), 55, 36-46. doi:10.1016/j.amsu.2020.04.016
Phuong, L., & Rajdev, L. (2020). Immunotherapy in Anal Cancer. Curr Oncol Rep, 22(9), 94. doi:10.1007/s11912-020-00946-3
Pineda, C. E., & Welton, M. L. (2009). Management of anal squamous intraepithelial lesions. Clin Colon Rectal Surg, 22(2), 94-101. doi:10.1055/s-0029-1223840
Roberts, J. R., Siekas, L. L., & Kaz, A. M. (2017). Anal intraepithelial neoplasia: A review of diagnosis and management. World J Gastrointest Oncol, 9(2), 50-61. doi:10.4251/wjgo.v9.i2.50
Row, D., & Weiser, M. R. (2009). Anorectal melanoma. Clin Colon Rectal Surg, 22(2), 120-126. doi:10.1055/s-0029-1223844
Rüschoff, J., Aust, A., Middel, P., & Heinmöller, E. (2011). [Anal cancer: diagnostic and differential diagnostic issues]. Pathologe, 32(4), 336-344. doi:10.1007/s00292-011-1440-4
Sauter, M., Keilholz, G., Kranzbühler, H., Lombriser, N., Prakash, M., Vavricka, S. R., & Misselwitz, B. (2016). Presenting symptoms predict local staging of anal cancer: a retrospective analysis of 86 patients. BMC Gastroenterol, 16, 46. doi:10.1186/s12876-016-0461-0
Shenoy, S., Nittala, M., & Assaf, Y. (2019). Anal carcinoma in giant anal condyloma, multidisciplinary approach necessary for optimal outcome: Two case reports and review of literature. World J Gastrointest Oncol, 11(2), 172-180. doi:10.4251/wjgo.v11.i2.172
Siddharthan, R. V., Lanciault, C., & Tsikitis, V. L. (2019). Anal intraepithelial neoplasia: diagnosis, screening, and treatment. Ann Gastroenterol, 32(3), 257-263. doi:10.20524/aog.2019.0364
Siegel, R. L., Miller, K. D., Wagle, N. S., & Jemal, A. (2023). Cancer statistics, 2023. CA Cancer J Clin, 73(1), 17-48. doi:10.3322/caac.21763
Surabhi, V. R., Menias, C. O., Amer, A. M., Elshikh, M., Katabathina, V. S., Hara, A. K., & Siegel, C. L. (2016). Tumors and Tumorlike Conditions of the Anal Canal and Perianal Region: MR Imaging Findings. Radiographics, 36(5), 1339-1353. doi:10.1148/rg.2016150209
Tchelebi, L. T., Eng, C., Messick, C. A., Hong, T. S., Ludmir, E. B., Kachnic, L. A., & Zaorsky, N. G. (2022). Current treatment and future directions in the management of anal cancer. CA Cancer J Clin, 72(2), 183-195. doi:10.3322/caac.21712
Uronis, H. E., & Bendell, J. C. (2007). Anal cancer: an overview. Oncologist, 12(5), 524-534. doi:10.1634/theoncologist.12-5-524
Young, A. N., Jacob, E., Willauer, P., Smucker, L., Monzon, R., & Oceguera, L. (2020). Anal Cancer. Surg Clin North Am, 100(3), 629-634.
The anal region, which is the end of the digestive system, has a complex anatomical arrangement. Surgeons interested in the anal region need to have the best knowledge about the anatomy of this region and the types of anal cancer that occur. Although anal cancers are rare, they are common, especially among young men. The reason for the increase in the rate of anal cancer is due to the increase in HPV and the high survival rate of individuals with HIV infection. In this study, the reasons why anal cancer occurs, how its formation is detected, what types of anal cancer are, how many stages it is divided into, macroscopic diagnosis of its stages, what kind of findings it contains as well as tumors, and the treatment processes of cancer are discussed.
Aigner, F., & Siegel, R. (2023). [Diagnostics, treatment and aftercare of anal cancer]. Chirurgie (Heidelb), 94(10), 890-898. doi:10.1007/s00104-023-01849-2
Al Hallak, M. N., & Zouain, N. (2009). Extramammary Perianal Paget's Disease. Case Rep Gastroenterol, 3(3), 332-337. doi:10.1159/000256382
Cacheux, W., Lievre, A., De La Rochefordiere, A., Dieumegard, B., Cvitkovic, F., Labib, A., & Buecher, B. (2012). Chemotherapy in the treatment of anal canal carcinoma. Dig Liver Dis, 44(10), 803-811. doi:10.1016/j.dld.2012.04.013
Chumbalkar, V., Jennings, T. A., Ainechi, S., Lee, E. C., & Lee, H. (2016). Extramammary Paget's Disease of Anal Canal Associated With Rectal Adenoma Without Invasive Carcinoma. Gastroenterology Res, 9(6), 99-102. doi:10.14740/gr727e
Ciombor, K. K., Ernst, R. D., & Brown, G. (2017). Diagnosis and Diagnostic Imaging of Anal Canal Cancer. Surg Oncol Clin N Am, 26(1), 45-55. doi:10.1016/j.soc.2016.07.002
Cleary, R. K., Schaldenbrand, J. D., Fowler, J. J., Schuler, J. M., & Lampman, R. M. (1999). Perianal Bowen's disease and anal intraepithelial neoplasia: review of the literature. Dis Colon Rectum, 42(7), 945-951. doi:10.1007/bf02237107
Dandapani, S. V., Eaton, M., Thomas, C. R., Jr., & Pagnini, P. G. (2010). HIV- positive anal cancer: an update for the clinician. J Gastrointest Oncol, 1(1), 34-44. doi:10.3978/j.issn.2078-6891.2010.005
Dee, E. C., Byrne, J. D., & Wo, J. Y. (2021). Evolution of the Role of Radiotherapy for Anal Cancer. Cancers (Basel), 13(6). doi:10.3390/cancers13061208
Gami, B., Kubba, F., & Ziprin, P. (2014). Human papilloma virus and squamous cell carcinoma of the anus. Clin Med Insights Oncol, 8, 113-119. doi:10.4137/cmo.S13241
Gilshtein, H., & Khoury, W. (2015). Surgical management of anal cancer. Minerva Chir, 70(2), 141-145.
Gondal, T. A., Chaudhary, N., Bajwa, H., Rauf, A., Le, D., & Ahmed, S. (2023). Anal Cancer: The Past, Present and Future. Curr Oncol, 30(3), 3232-3250. doi:10.3390/curroncol30030246
Grulich, A. E., Poynten, I. M., Machalek, D. A., Jin, F., Templeton, D. J., & Hillman, R. J. (2012). The epidemiology of anal cancer. Sex Health, 9(6), 504-508. doi:10.1071/sh12070
Hoedema, R. E. (2018). Anal Intraepithelial Neoplasia and Squamous Cell Cancer of the Anus. Clin Colon Rectal Surg, 31(6), 347-352. doi:10.1055/s-0038-1668104
Jácome, A. A., Morris, V. K., & Eng, C. (2022). The Role of Immunotherapy in the Treatment of Anal Cancer and Future Strategies. Curr Treat Options Oncol, 23(8), 1073-1085. doi:10.1007/s11864-022-00939-3
Khandwala, P., Singhal, S., Desai, D., Parsi, M., & Potdar, R. (2021). HIV-Associated Anal Cancer. Cureus, 13(5), e14834. doi:10.7759/cureus.14834
Leonard, D., Beddy, D., & Dozois, E. J. (2011). Neoplasms of anal canal and perianal skin. Clin Colon Rectal Surg, 24(1), 54-63. doi:10.1055/s-0031-1272824
Maas, M., Tielbeek, J. A. W., & Stoker, J. (2020). Staging of Anal Cancer: Role of MR Imaging. Magn Reson Imaging Clin N Am, 28(1), 127-140. doi:10.1016/j.mric.2019.09.005
Malaguarnera, G., Madeddu, R., Catania, V. E., Bertino, G., Morelli, L., Perrotta, R. E., & Latteri, S. (2018). Anorectal mucosal melanoma. Oncotarget, 9(9), 8785-8800. doi:10.18632/oncotarget.23835
Morton, M., Melnitchouk, N., & Bleday, R. (2018). Squamous cell carcinoma of the anal canal. Curr Probl Cancer, 42(5), 486-492. doi:10.1016/j.currproblcancer.2018.11.001
Palaniappan, V., & Karthikeyan, K. (2022). Bowen's Disease. Indian Dermatol Online J, 13(2), 177-189. doi:10.4103/idoj.idoj_257_21
Pessia, B., Romano, L., Giuliani, A., Lazzarin, G., Carlei, F., & Schietroma, M. (2020). Squamous cell anal cancer: Management and therapeutic options. Ann Med Surg (Lond), 55, 36-46. doi:10.1016/j.amsu.2020.04.016
Phuong, L., & Rajdev, L. (2020). Immunotherapy in Anal Cancer. Curr Oncol Rep, 22(9), 94. doi:10.1007/s11912-020-00946-3
Pineda, C. E., & Welton, M. L. (2009). Management of anal squamous intraepithelial lesions. Clin Colon Rectal Surg, 22(2), 94-101. doi:10.1055/s-0029-1223840
Roberts, J. R., Siekas, L. L., & Kaz, A. M. (2017). Anal intraepithelial neoplasia: A review of diagnosis and management. World J Gastrointest Oncol, 9(2), 50-61. doi:10.4251/wjgo.v9.i2.50
Row, D., & Weiser, M. R. (2009). Anorectal melanoma. Clin Colon Rectal Surg, 22(2), 120-126. doi:10.1055/s-0029-1223844
Rüschoff, J., Aust, A., Middel, P., & Heinmöller, E. (2011). [Anal cancer: diagnostic and differential diagnostic issues]. Pathologe, 32(4), 336-344. doi:10.1007/s00292-011-1440-4
Sauter, M., Keilholz, G., Kranzbühler, H., Lombriser, N., Prakash, M., Vavricka, S. R., & Misselwitz, B. (2016). Presenting symptoms predict local staging of anal cancer: a retrospective analysis of 86 patients. BMC Gastroenterol, 16, 46. doi:10.1186/s12876-016-0461-0
Shenoy, S., Nittala, M., & Assaf, Y. (2019). Anal carcinoma in giant anal condyloma, multidisciplinary approach necessary for optimal outcome: Two case reports and review of literature. World J Gastrointest Oncol, 11(2), 172-180. doi:10.4251/wjgo.v11.i2.172
Siddharthan, R. V., Lanciault, C., & Tsikitis, V. L. (2019). Anal intraepithelial neoplasia: diagnosis, screening, and treatment. Ann Gastroenterol, 32(3), 257-263. doi:10.20524/aog.2019.0364
Siegel, R. L., Miller, K. D., Wagle, N. S., & Jemal, A. (2023). Cancer statistics, 2023. CA Cancer J Clin, 73(1), 17-48. doi:10.3322/caac.21763
Surabhi, V. R., Menias, C. O., Amer, A. M., Elshikh, M., Katabathina, V. S., Hara, A. K., & Siegel, C. L. (2016). Tumors and Tumorlike Conditions of the Anal Canal and Perianal Region: MR Imaging Findings. Radiographics, 36(5), 1339-1353. doi:10.1148/rg.2016150209
Tchelebi, L. T., Eng, C., Messick, C. A., Hong, T. S., Ludmir, E. B., Kachnic, L. A., & Zaorsky, N. G. (2022). Current treatment and future directions in the management of anal cancer. CA Cancer J Clin, 72(2), 183-195. doi:10.3322/caac.21712
Uronis, H. E., & Bendell, J. C. (2007). Anal cancer: an overview. Oncologist, 12(5), 524-534. doi:10.1634/theoncologist.12-5-524
Young, A. N., Jacob, E., Willauer, P., Smucker, L., Monzon, R., & Oceguera, L. (2020). Anal Cancer. Surg Clin North Am, 100(3), 629-634.