Synthesis, Spectroscopic and Theoretical Characterization of Chiral Benzimidazole-Based Schiff Bases

Abstract

Schiff bases are versatile compounds widely utilized in organic chemistry, serving as essential intermediates, starting materials, ligands, and catalysts. Their increasing significance in both practical applications and biological studies, particularly the notable bioactivity of their transition metal complexes, has sparked extensive scientific interest. In this context, the present study focuses on synthesizing novel chiral Schiff bases derived from benzimidazole, utilizing natural chiral amino acids as starting points. The condensation of these precursors with 4-(dimethylamino)benzaldehyde yielded four new Schiff base derivatives. To further investigate their potential biological activity, molecular docking studies were performed to examine the binding interactions between the synthesized compounds and selected target proteins. The results indicated that some derivatives showed high binding affinity, implying potential inhibitory activity. These findings highlight the promising pharmacological relevance of the synthesized compounds and support their future exploration in drug discovery research. Moreover, their coordination ability suggests potential applications as ligands in transition metal complexation.

Keywords

• Benzimidazole
• Schiff base
• Molecular docking
• Biological activity

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