Synthesis, Spectroscopic and Theoretical Characterization of Chiral Benzimidazole-Based Schiff Bases

Yıl 2026, Cilt: 9 Sayı: 1, 192 - 205, 15.01.2026

Nuriye Tuna Subaşı

https://doi.org/10.34248/bsengineering.1776780

https://izlik.org/JA45NF56KE

Öz

Schiff bases are versatile compounds widely utilized in organic chemistry, serving as essential intermediates, starting materials, ligands, and catalysts. Their increasing significance in both practical applications and biological studies, particularly the notable bioactivity of their transition metal complexes, has sparked extensive scientific interest. In this context, the present study focuses on synthesizing novel chiral Schiff bases derived from benzimidazole, utilizing natural chiral amino acids as starting points. The condensation of these precursors with 4-(dimethylamino)benzaldehyde yielded four new Schiff base derivatives. To further investigate their potential biological activity, molecular docking studies were performed to examine the binding interactions between the synthesized compounds and selected target proteins. The results indicated that some derivatives showed high binding affinity, implying potential inhibitory activity. These findings highlight the promising pharmacological relevance of the synthesized compounds and support their future exploration in drug discovery research. Moreover, their coordination ability suggests potential applications as ligands in transition metal complexation.

Anahtar Kelimeler

Benzimidazole , Schiff base , Molecular docking , Biological activity

Etik Beyan

No ethics committee approval was obtained for this research as no studies were conducted on animals or humans.

Destekleyen Kurum

Kırşehir Ahi Evran University

Proje Numarası

MMF.A4.23.007

Teşekkür

I would like to thank the Scientific Research Projects Coordination Unit of Kırşehir Ahi Evran University for supporting this study under the project number MMF.A4.23.007. Additionally, I would like to express my deep gratitude to Assoc. Prof. Tuncay Karakurt for his invaluable help and contributions to the theoretical calculations of this research.

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