Studies of Glutathione Reductase Inhibitors Activity of Copper(II) Complexes

Abstract

(S)-(+) - phenylglycinol, (1S, 2R)-2-amino-1, 2-diphenylethanol and (R)-(+)-2-amino-1, 1, 3-triphenylpropanol based chiral copper (II) complex of Schiff bases were synthesized. The effects of these compounds on glutathione reductase enzyme were investigated. The best inhibitory effect was found to belong to complex 3.

Keywords

• Schiff bases,copper (II) complexes,Glutathione Reductase

Bakır(II) Komplekslerinin Glutatyon Redüktaz İnhibitor Çalışması

Abstract

(S)-(+)-fenilglisinol, (1S, 2R) -2-amino-1,2-difeniletanol’in ve (R)-(+)-2-amino-1,1,3-trifenilpropanol bazlı kiral Schiff bazlarının bakır (II) kompleksi sentezlendi. Bu bileşiklerin glutatyon redüktaz enzimi üzerindeki etkileri incelendi. En iyi inhibitör etkisinin kompleks 3'e ait olduğu belirlenmiştir.

Keywords

• Schiff baz,bakır (II) kompleksleri,Glutatyon Redüktaz

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