Studies of Glutathione Reductase Inhibitors Activity of Copper(II) Complexes

Year 2019, Volume: 6, 117 - 122, 30.09.2019

Turgay Tunç

https://doi.org/10.35193/bseufbd.577450

Abstract

(S)-(+) - phenylglycinol, (1S, 2R)-2-amino-1,
2-diphenylethanol and (R)-(+)-2-amino-1, 1, 3-triphenylpropanol based chiral
copper (II) complex of Schiff bases were synthesized. The effects of these
compounds on glutathione reductase enzyme were investigated. The best
inhibitory effect was found to belong to complex 3.

Keywords

Schiff bases, copper (II) complexes, Glutathione Reductase

Bakır(II) Komplekslerinin Glutatyon Redüktaz İnhibitor Çalışması

Abstract

(S)-(+)-fenilglisinol, (1S, 2R)
-2-amino-1,2-difeniletanol’in ve
(R)-(+)-2-amino-1,1,3-trifenilpropanol bazlı kiral Schiff bazlarının bakır (II)
kompleksi sentezlendi. Bu bileşiklerin glutatyon redüktaz enzimi üzerindeki
etkileri incelendi. En iyi inhibitör etkisinin kompleks 3'e ait olduğu
belirlenmiştir.

Keywords

Schiff baz, bakır (II) kompleksleri, Glutatyon Redüktaz

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