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COVID-19 Hastalığında Görülen Ağız Bulguları

Year 2021, , 178 - 184, 31.12.2021
https://doi.org/10.34084/bshr.1030689

Abstract

Sars- Cov-2 virüsü, tüm dünyada hızla yayılım göstermiş, Mart 2020 tarihinden itibaren ise, Dünya Sağlık Örgütü (DSÖ) tarafından, dünya genelinde pandemi ilan edilmiştir. Covid-19'un genel semptomları olarak ateş, yorgunluk, öksürük, kas ağrısı, nefes darlığı, baş ağrısı, boğaz ağrısıdır ve pnömoni görülebilmektedir. Covid-19’da en sık görülen ağız semptomu ise hastaların %45’inde görülen tat bozukluklarıdır. Ayrıca hastalarda, herpetiform ve aft benzeri lezyonlar, kandidiyazis ve Kawasaki benzeri lezyonlar gibi çeşitli oral mukoza lezyonları görülebilmektedir. Bu derleme çalışmasının amacı, Covid-19 hastalığında görülen ağız bulgularını incelemektir.

References

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  • Da Silva Pedrosa M, Sipert CR, Nogueira FN. Altered taste in patients with COVID-19: the potential role of salivary glands. Oral Dis 2021; 27:798–800.
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Oral Symptoms in Covid-19 Disease

Year 2021, , 178 - 184, 31.12.2021
https://doi.org/10.34084/bshr.1030689

Abstract

SARS Cov-2 virus has spread rapidly all over the world, and since March 2020, it has been declared a worldwide pandemic by the World Health Organization (WHO). The general symptoms of COVID-19 are fever, fatigue, cough, myalgia, dyspnea, headache, sore throat and pneumonia. The most common oral symptom in COVID-19 is taste disorders, which is seen in 45% of patients. In addition, various oral mucosal lesions such as herpetiform and aphthous-like lesions, candidiasis and Kawasaki-like lesions can be observed in patients. The purpose of this review study is to examine the mouth findings seen in COVID-19 disease.

References

  • Sağlık Bakanlığı (2020). https://COVID19.saglik.gov.tr/ Eklenti/38597/0/COVID-19 rehberi genel bilgiler epidemiyoloji ve tani pdf, Türkiye Cumhuriyeti Sağlık Bakanlığı, Halk Sağlığı Genel Müdürlüğü, COVID-19 Rehberi, Genel Bilgiler Epidemiyolojı ve Tanı Bölümü, s;5-6, Güncellenme Tarihi:3.09.2020.
  • Corchuelo J, Ulloa FC. Oral manifestations in a patient with a history of asymptomatic COVID-19: Case report. Int J Infect Dis 2020;100:154-7. 7
  • Xu J, Chu M, Zhong F, et al. Digestive symptoms of COVID-19 and expression of ACE2 in digestive tract organs. Cell Death Discov 2020;6:1-8.
  • Martín Carreras-Presas C, Amaro Sánchez J, López-Sánchez AF, et al. Oral vesiculobullous lesions associated with SARS-CoV-2 infection. Oral Dis 2021;27:710-2.
  • Tapia ROC, Labrador AJP, Guimaraes DM, et al. Oral mucosal lesions in patients with SARS-CoV-2 infection. Report of four cases. Are they a true sign of COVID-19 disease? Spec Care Dent 2020;40:555-650.
  • Chary E, Carsuzaa F, Trijolet JP, et al. Prevalence and recovery from olfactory and gustatory dysfunctions in Covid-19 infection: A prospective multicenter study. Am J Rhinol Allergy 2020;34:686-93.
  • Seirafianpour F, Sodagar S, Pour Mohammad A, et al. Cutaneous manifestations and considerations in COVID‐19 pandemic: a systematic review. Dermatol Ther 2020; 33:13986.
  • Dos Santos JA, Normando AGC, Carvalho da Silva RL, et al. Oral mucosal lesions in a COVID-19 patient: New signs or secondary manifestations? Int J Infect Dis 2020;97:326-8.
  • Dos Santos JA, Normando AGC, da Silva RLC, et al. Oral manifestations in patients with COVID-19: A living systematic review. J Dent Res 2021;100:141-54.
  • Aggarwal S, Garcia-Telles N, Aggarwal G, et al. Clinical features, laboratory characteristics, and outcomes of patients hospitalized with coronavirus disease 2019 (COVID-19): early report from the United States. Diagnosis 2020;7:91-96.
  • Dos Santos JA, Normando AGC, Carvalho da Silva RL, et al. Oral Manifestations in Patients with COVID-19: A 6-Month Update. J Dent Res 2021; doi: 10.1177/00220345211029637.
  • Finsterer J, Stollberger C. Causes of hypogeusia/hyposmia in SARSCoV2 infected patients. J Med Virol 2020; 92:1793–1794.
  • Kinnamon SC, Cummings TA. Chemosensory transduction mechanisms in taste. Annu Rev Physiol 1992; 54:715–731.
  • Milanetti E, Miotto M, Di Rienzo L, et al. In-Silico Evidence for a Two Receptor Based Strategy of SARS-CoV-2. Front Mol Biosci 2021; doi: 10.3389/fmolb.2021.690655.
  • Pushpass RG, Pellicciotta N, Kelly C, et al. Reduced salivary mucin binding and glycosylation in older adults influences taste in an in vitro cell model. Nutrients 2019;11:2280.
  • Vaira LA, Salzano G, Fois AG, et al. Potential pathogenesis of ageusia and anosmia in COVID-19 patients. Int Forum Allergy Rhinol 2020; 10:1103–1104.
  • Nataf S. An alteration of the dopamine synthetic pathway is possibly involved in the pathophysiology of COVID-19. J Med Virol 2020; 92:1743–1744.
  • Tsuruoka S, Wakaumi M, Nishiki K, et al. Subclinical alteration of taste sensitivity induced by candesartan in healthy subjects. Br J Clin Pharmacol 2004;57:807–812.
  • Unnikrishnan D, Murakonda P, Dharmarajan TS. If it is not cough, it must be dysgeusia: differing adverse effects of angiotensin-converting enzyme inhibitors in the same individual. J Am Med Dir Assoc 2004;5:107–110.
  • Abubakr N, Salem ZA, Kamel AHM. Oral manifestations in mild-tomoderate cases of COVID-19 viral infection in the adult population. Dent Med Probl 2021; 58:7–15.
  • Biadsee A, Biadsee A, Kassem F, et al. Olfactory and oral manifestations of COVID-19: sex-related symptoms— a potential pathway to early diagnosis. Otolaryngol Head Neck Surg 2020; 163:722–728.
  • Chen L, Zhao J, Peng J, et al. Detection of SARS-CoV-2 in saliva and characterization of oral symptoms in COVID-19 patients. Cell Prolif 2020;53:12923.
  • Fantozzi PJ, Pampena E, Di Vanna D, et al. Xerostomia, gustatory and olfactory dysfunctions in patients with COVID-19. Am J Otolaryngol 2020;41:102721.
  • Sinjari B, D’Ardes D, Santilli M, et al. SARS-CoV-2 and oral manifestation:an observational, human study. J Clin Med 2020; 9:3218.
  • Xu H, Zhong L, Deng J, et al. High expression of ACE2 receptor of 2019-nCoV on the epithelial cells of oral mucosa. Int J Oral Sci 2020;12:1-5.
  • Tsuchiya H. Oral symptoms associated with COVID-19 and their pathogenic mechanisms: A Literature Review. Dent J 2021;9:32.
  • Freni F, Meduri A, Gazia F, et al. Symptomatology in head and neck district in coronavirus disease (COVID-19): a possible neuroinvasive action of SARS-CoV-2. Am J Otolaryngol 2020;41:102612.
  • Reza-Zaldívar EE, Hernández-Sapiéns MA, Minjarez B, et al. Infection mechanism of SARS-COV-2 and its implication on the nervous system. Front Immunol 2021;11:621735.
  • Saniasiaya J. Xerostomia and COVID-19: unleashing Pandora’s box. Ear Nose Throat J 2021;100:139.
  • Belchior Fontenele MN, Pedrosa MDS. Xerostomia and taste alterations in COVID-19. Ear Nose Throat J 2021;100:186–187.
  • Da Silva Pedrosa M, Sipert CR, Nogueira FN. Altered taste in patients with COVID-19: the potential role of salivary glands. Oral Dis 2021; 27:798–800.
  • Riad A, Kassem I, Hockova B, et al. Halitosis in COVID-19 patients. Spec Care Dentist 2021; 41:282–285.
  • Lechien JR, Chetrit A, Chekkoury-Idrissi Y, et al. Parotitis-like symptoms associated with COVID-19, France, March–April 2020. Emerg Infect Dis 2020; 26: 2270–2271.
  • Riad A, Kassem I, Badrah M, et al. Acute parotitis as a presentation of COVID-19? Oral Dis 2020; doi:10.1111/odi.13571
  • Fisher J, Monette DL, Patel KR, et al. COVID-19 associated parotitis. Am J Emerg Med 2021;39:254.e1–254.e3
  • Capaccio P, Pignataro L, Corbellino M, et al. Acute parotitis: a possible precocious clinical manifestation of SARS-CoV-2 infection? Otolaryngol Head Neck Surg 2020;163:182-183.
  • Slots J. Periodontitis: facts, fallacies and the future. Periodontol 2000 2017;75:7-23.
  • Bozoglan A, Ertugrul AS, Taspınar M, et al. Determining the relationship between atherosclerosis and periodontopathogenic microorganisms in chronic periodontitis patients. Acta Odontol Scand 2017;75:233-42.
  • Pitones-Rubio V, Chávez-Cortez EG, Hurtado- Camarena A, et al. Is periodontal disease a risk factor for severe COVID-19 illness? Med Hypotheses 2020;144:109969.
  • Cappuyns I, Gugerli P, Mombelli A. Viruses in periodontal disease-a review. Oral Dis 2005;11:219-9.
  • Badran Z, Gaudin A, Struillou X, et al. Periodontal pockets: A potential reservoir for SARS-CoV-2? Med Hypotheses 2020;143:109907.
  • Herrera D, Serrano J, Roldán S, et al. Is the oral cavity relevant in SARS-CoV-2 pandemic? Clin Oral Investig 2020;24:2925-30.
  • Sampson V. Oral hygiene risk factor. Br Dent J. 2020;228:569.
  • Sahni V, Gupta S. COVID-19 & Periodontitis: The cytokine connection. Med Hypotheses 2020; 144:109908.
  • Bozoğlan A, Yılmaz Bozoğlan M. Periodontal hastalık, SARS-CoV-2 ve ilaçlar. Emingil G, editör. Diş Hastalıkları ve COVID-19. 1. Baskı. Ankara: Türkiye Klinikleri; 2020. p.75-82.
  • Sampson V, Kamona N, Sampson A. Could there be a link between oral hygiene and the severity of SARS-CoV-2 infections? Br Dent J 2020;228:971-5.
  • Toraldo DM, Conte L. Influence of the lung microbiota Dysbiosis in chronic obstructive pulmonary disease exacerbations: the controversial use of corticosteroid and antibiotic treatments and the role of Eosinophils as a disease marker. J Clin Med Res 2019;11:667-675.
  • Scannapieco FA, Genco RJ. Association of periodontal infections with atherosclerotic and pulmonary diseases. J Periodontal Res 1999;34:340-5.
  • Scannapieco FA. Position paper of The American Academy of Periodontology: periodontal disease as a potential risk factor for systemic diseases. J Periodontol 1998;69:841-50.
  • Marouf N, Cai W, Said KN, et al. Association between periodontitis and severity of COVID-19 infection: A case–control study. J Clin Periodontol 2021;48: 483-91.
  • Anand PS, Jadhav P, Kamath KP, et al. A case-control study on the association between periodontitis and coronavirus disease (COVID-19). J Periodontol 2021; doi:10.1002/JPER.21-0272
  • Patel J, Woolley J. Necrotizing periodontal disease: oral manifestation of COVID-19. Oral Dis 2021;27:768-9.
  • Ismail MT, Naser MM. Parotitis as clinical manifestation of COVID-19 infection, emergency physician experience: A case report. Medicine 2020; 9:1089-92.
  • Aghazadeh N, Homayouni M, Sartori-Valinotti JC. Oral vesicles and acral erythema: report of a cutaneous manifestation of COVID-19. Int J Dermatol 2020;59:1153-4.
  • Díaz Rodríguez M, Jimenez Romera A, Villarroel M. Oral manifestations associated with COVID-19. Oral Dis 2020; doi: 10.1111/odi.13555
  • Kammerer T, Walch J, Flaig M, et al. COVID-19 associated herpetic gingivostomatitis. Clin Exp Dermatol 2021;46:174-6.
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There are 86 citations in total.

Details

Primary Language Turkish
Subjects Dentistry
Journal Section Review
Authors

Merve Köseoğlu 0000-0001-9110-9586

Mustafa Altındiş 0000-0003-0411-9669

Publication Date December 31, 2021
Acceptance Date December 6, 2021
Published in Issue Year 2021

Cite

AMA Köseoğlu M, Altındiş M. COVID-19 Hastalığında Görülen Ağız Bulguları. J Biotechnol and Strategic Health Res. December 2021;5(3):178-184. doi:10.34084/bshr.1030689
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