Triglyceride-Glucose Index is a novel predictor of colorectal cancer

Abstract

Aim: Colorectal cancer is the leading cause of cancer-related mortality. Metabolic syndrome is associated with obesity, pre-diabetes, and dyslipidemia. The purpose of the study was to investigate the effects of TyG Index as a novel biomarker on CRC risk. Material and Method: The study was conducted with 256 people in total, including the CRC (n=124) and Control Groups (n=132). TyG Index was calculated by using fasting triglycerides and glucose with the formula Ln [fasting TGs (mg/dL) x fasting glucose (mg/dL)/2]. The performance of the TyG Index to predict the presence of CRC was also evaluated. Results: Metabolic parameters associated with insulin resistance were found to be at statistically significant levels in the CRC Group. Fasting plasma glucose, triglyceride, insulin, hemoglobin A1c, and GGT were also statistically significant. It was also determined that the cut-off value of the TyG Index for the presence of CRC was 4.49 (AUC = 0.782, sensitivity 77%, specificity = 78.4%, and p=0.002). Conclusion: In the present study, it was found that the TyG Index is associated with the risk of CRC and can be used as a novel biomarker in high-risk CRC cases.

Keywords

• TyG Index
• Colorectal cancer
• Insulin resistance.

Trigliserit-Glikoz İndeksi, kolorektal kanserin yeni bir belirleyicisidir

Abstract

Amaç: Kolorektal kanser, kansere bağlı ölümlerin önde gelen nedenidir. Metabolik sendrom, obezite, pre-diyabet ve dislipidemi ile ilişkilidir. Çalışmanın amacı, yeni bir biyobelirteç olarak TyG İndeksinin KRK riski üzerindeki etkilerini araştırmaktır. Gereç ve Yöntem: Çalışma, KRK (n=124) ve Kontrol Grubu (n=132) olmak üzere toplam 256 kişi ile gerçekleştirildi. TyG İndeksi, Ln [açlık TG'ler (mg/dL) x açlık glikozu (mg/dL)/2] formülü ile açlık trigliseritleri ve glukoz kullanılarak hesaplandı. TyG İndeksinin CRC varlığını tahmin etme performansı da değerlendirildi. Bulgular: İnsülin direnci ile ilişkili metabolik parametrelerin KRK Grubunda istatistiksel olarak anlamlı düzeyde olduğu bulundu. Açlık plazma glukozu, trigliserit, insülin, hemoglobin A1c ve GGT de istatistiksel olarak anlamlıydı. TyG Index'in KRK varlığı için cut-off değerinin de 4,49 olduğu saptandı (EAA=0,782, sensitivite %77, spesifite=%78,4 ve p=0,002). Sonuç: Bu çalışmada, TyG İndeksinin KRK riski ile ilişkili olduğu ve yüksek riskli KRK olgularında yeni bir biyobelirteç olarak kullanılabileceği bulundu.

Keywords

• TyG İndeksi
• Kolorektal kanser
• İnsülin direnci

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