Comparision of Perioperative Fluoropyrimidine, Docetaxel And Oxaliplatin Regimen with Adjuvant Fluoropyrimidine and Oxaliplatine Regimen In Operable Gastric Cancer Patients

Abstract

Aim: As no study has compared perioperative 5-Fluorouracil (5-FU), oxaliplatin, and docetaxel (FLOT) chemotherapy regimens with postoperative adjuvant oral capecitabine and oxaliplatin/5-FU and oxaliplatin (CAPEOX/FOLFOX) chemotherapy regimens, the goal of this study was to compare them in terms of median and overall survival of operable gastric cancers. Methods: This single-center, retrospective study recruited 59 subjects (17 females and 42 males) with at least T2 or more invasive gastric cancers with or without positive lymph node(s). All the patients underwent total or subtotal ((sub) total) gastric resection with D2 lymph node dissection. The Statistical Package for the Social Sciences (IBM SPSS) 26.0 program was used to statistically analyze the research findings. Results: The peri-operative FLOT treatment group with 30 patients displayed significantly more advanced clinical nodal (cN) stage (p<0.005), more comorbidities (p=0.025), and worse Eastern Cooperative Oncology Group (ECOG) performance (p=0.007) during diagnosis than the adjuvant CAPEOX/FOLFOX treatment group (29 patients). The median overall survival (mOS) and median progression free survival (mPFS) were found to be statistically significant (21 vs. 14 months, p=0.018 and 17 versus 8.5 months p=0.009, respectively) higher in favor of the adjuvant treatment group. Conclusion: According to real-life data, younger and earlier stage patients who chose surgery as the first treatment option to eliminate cancer as soon as possible had longer mOS and mPFS.

Keywords

• Gastric
• cancer
• neoadjuvant
• adjuvant
• treatment.

Ameliyata Uygun Mide Kanseri Hastalarında Perioperatif Floropirimidin, Docetaxel ve Oksaliplatin Rejiminin Adjuvan Floropirimidin ve Oksaliplatin Rejimi ile Karşılaştırılması

Abstract

Amaç: Bu çalışma, perioperatif 5-Florourasil (5-FU), oksaliplatin ve docetaxel (FLOT) kemoterapi rejimleri postoperatif adjuvan oral kapesitabin ve oksaliplatin/5-FU ve oksaliplatin (CAPEOX/FOLFOX) kemoterapi rejimleriyle karşılaştırılması amacıyla planlanmıştır. Gereç ve Yöntem: Bu tek merkezli, retrospektif çalışmaya en az T2 veya daha fazla invaziv mide kanseri olan ve pozitif lenf nodu(ları) olan veya olmayan 59 hasta (17 kadın ve 42 erkek) dahil edildi. Tüm hastalara D2 lenf nodu diseksiyonu ile birlikte total veya subtotal ((sub) total) mide rezeksiyonu uygulandı. Araştırma bulgularını istatistiksel olarak analiz etmek için Sosyal Bilimler İstatistik Paketi (IBM SPSS) 26.0 programı kullanıldı. Bulgular: 30 hastadan oluşan perioperatif FLOT tedavi grubu, adjuvan CAPEOX/FOLFOX tedavi grubuna (29 hasta) göre tanı sırasında önemli ölçüde daha ileri klinik nodal (cN) evre (p<.005), daha fazla komorbidite (p=.025) ve daha kötü Doğu Kooperatif Onkoloji Grubu (ECOG) performansı (p=.007) gösterdi. Medyan genel anket (mOS) ve medyan ilerleme serbest anket (mPFS)'nin adjuvan tedavi grubunun lehine istatistiksel olarak anlamlı (sırasıyla 21'e karşı 14 ay, p=.018 ve 17'ye karşı 8,5 ay p=.009) daha yüksek olduğu bulundu. Sonuç: Gerçek yaşam verilerine göre, kanseri mümkün olan en kısa sürede ortadan kaldırmak için ilk tedavi seçeneği olarak cerrahiyi seçen daha genç ve daha erken evre hastaların daha uzun mOS ve mPFS'lerinin olduğu görülmüştür.

Keywords

• Gastrik
• kanser
• neoadjuvan
• adjuvan
• tedavi.

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