Inflammatory Bowel Diseases and Intestinal Microbiota

Abstract

The cause of Crohn’s Disease (CH) and Ulcerative Colitis (UC) is infl ammatory bowel disease (IBD) in which the genetic and environmental factors play a role in the pathogenesis. The incidence of UC in the whole world has been reported as 6.3-24.3 / 100.000, and the incidence of CH 5-20.2 / 100.000 (1). In Turkey, the prevalence of IBD is 36 / 100.000 according to the data of 2007. There are still signifi cant unmet needs in the treatment strategies for infl ammatory bowel disease, along with the growing developments in recent years. Patients are seeking safer, immunomodulatory and immunosuppressive treatment alternatives, and modulation of intestinal microbiota in IBD seems conceptually attractive and realistic (2). However, the inconsistent results in the studies and publications still do not provide suffi cient evidence on the subject and therefore studies are insuffi cient to assess the clinical fi ndings of the findings obtained. In this article, the etiopathogenetic and therapeutic relationship between IBD and intestinal microbiota has been tried to be observed in the light of current knowledge

Keywords

• Infl ammatory Bowel Diseases,IBD,Microbiota

İnflamatuar Barsak Hastalığı Ve Barsak Mikrobiyotası

Abstract

Crohn Hastalığı (CH) ve Ülseratif Kolit (ÜK) nedeni kesin olarak bilinmeyen, patogenezinde genetik ve çevresel faktörlerin rol aldığı infl amatuar barsak hastalıklarıdır (İBH). Tüm dünyada ÜK insidansı, 6,3-24,3/100.000, CH insidansı 5-20,2/100.000 olarak bildirilmiştir (1). Türkiye’de ise İBH derneğinin 2007 yılındaki verilerine göre İBH prevalansı, 36/100.000 dır. İnfl amatuar barsak hastalığı için tedavi stratejilerinde son yıllarda artan gelişmeler olmakla beraber hala karşılanmamış önemli ihtiyaçlar mevcuttur. Hastalar daha güvenli, immünmodülatör ve immünsüpresif tedaviye alternatif olabilecek tedaviler aramakta olup bu anlamda İBH’da barsak mikrobiyotasının modülasyonu kavramsal olarak çekici ve gerçekçi gözükmektedir (2). Fakat çalışma ve yayınlardaki ikna edici olmayan sonuçlar konu ile ilgili halen yeterli kanıtları gösterememiştir ve bu nedenle çalışmalar elde edilen bulguların klinik pratiğe yansımasını değerlendirme konusunda yetersiz kalmaktadır. Bu yazıda İBH ile barsak mikrobiyotası arasındaki etyopatogenetik ve terapötik ilişki güncel bilgiler ışığında gözden geçirilmeye çalışılmıştır.

Keywords

• İnfl amatuar Bağırsak Hastalıkları,İBH,Mikrobiyota

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