Hedefe Yönelik Kanser İlaç Dizaynında Isı Şok Proteni 90

Year 2019, , 161 - 169, 31.12.2019

Aykut Özgür , İsa Gökçe

https://doi.org/10.34084/bshr.647101

Abstract

Isı şok proteini
90 (HSP90) korunmuş bir proteindir ve onkogenik proteinlerin katlanması ve
stabilizasyonundan görevlidir. Bundan dolayı HSP90’nın şaperon görevinin
inhibisyonu hedefe spesifik kanser tedavisinde önemli bir terapötik strateji
olmaktadır. Çok sayıda doğal ve sentetik bileşikler klinik öncesi ve klinik
çalışmalarda HSP90 inhibitörü olarak değerlendirilmiştir. Bu çalışmada, HSP90
inhibisyonunun tümörogenezdeki moleküler mekanizmaları ve HSP90
inhibitörlerinin genel özellikleri tartışılacaktır. 

Keywords

Isı şok proteinleri, Kanser, Onkoloji, Hücresel Stres

Heat Shock Protein 90 in Target Spesifıc Cancer Drug Design

Abstract

Heat shock protein 90 (HSP90) is
conserved chaperone protein which is involved in proper folding and
stabilization of oncogenic proteins. Therefore, inhibition
of the chaperone function of HSP90 has been significant therapeutic strategy in
target specific cancer treatment. Numerous natural and synthetic
compounds have been evaluated as potential HSP90 inhibitor in pre-clinical and
clinical studies. In this paper, we will discuss the molecular mechanisms of
HSP90 inhibition in tumorigenesis and the
general properties and structures of the HSP90 inhibitors.

Keywords

Heat shock proteins, Cancer, Oncology, Cellular stress

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