COVID-19 Immunopathogenesis and Cytokine Storm

Abstract

Coronavirus pandemic is a global health crisis that continues due to COVID-19 caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Although mild, flu-like symptoms are seen in the majority of patients affected by the virus, some patients experience serious complications such as pneumonia, acute respiratory distress syndrome, and organ failure due to hyperinflamation and cytokine storm syndrome. Information about the pathology of the disease is at a limited level. In this review, the pathogenesis of COVID-19 is examined under the available data.

Keywords

• SARS-CoV-2,COVID-19,immunopathogenesis,cytokine storm

COVID-19 İmmünopatogenezi ve Sitokin Fırtınası

Abstract

Koronavirüs pandemisi, ciddi akut solunum sendromu koronavirüs 2 (SARS-CoV-2)’nin neden olduğu COVID-19 nedeniyle devam eden küresel bir sağlık krizidir. Virüsten etkilenen hastaların çoğunda hafif, grip benzeri semptomlar görülse de bazı hastalarda pnömoni, akut solunum sıkıntısı sendromu ile hiperenflamasyon ve sitokin fırtınası sendromu kaynaklı organ yetmezliği gibi ciddi komplikasyonlar görülmektedir. Hastalığının patobiyolojisi ile ilgili bilgiler ise henüz sınırlı düzeydedir. Bu derlemede, mevcut veriler altında COVID-19 patogenezi irdelenmektedir.

Keywords

• SARS-CoV-2,COVID-19,immünopatogenez,sitokin fırtınası

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