Evaluation of Risk Factors in Diabetic Patients with Macrovascular Complications

Abstract

Objecive: In our study, we planned to investigate the risk factors of patients diagnosed with acute myocardial infarction or cerebrovascular event due to macrovascular complications of diabetes mellitus between 2015-2018. Material and Methods: A retrospective study included 48 patients with diabetes mellitus diagnosed with macrovascular complications, the control group consisted of 97 diabetic patients who had no macrovascular complications and that followed-up in our outpatient clinic. In the last 6 months of the patients who developed complications and the patients in the control group, laboratory results were examined and the risk factors were determined according to age, BMI, fasting blood glucose, Hba1C, MPV, RDW, PLT and creatinine parameters.Statistical analysis was performed with SPSS version 17.0 program. Normal distribution of the variables were evaluated according to histogram graphs and Kolmogorov-Smirnov test; In the independent groups, the T test was used to evaluate the nonparametric groups and the Mann Whitney U test was used. Results: As a result of our study, we found a statistically significant relationship with the development of macrovascular complications in diabetic patients, advanced age, progression in HbA1c level, MPV value >11,9 and creatinine levels above 1.2 mg / dl, but gender, BMI, fasting blood glucose, RDW and platelet values were similar in both groups. Conclusion: Based on the data obtained, we think that the follow-up of advanced age, MPV, creatinine, Hba1c values in the follow-up of diabetic patients and the deterioration in these parameters may guide us in terms of the development of macrovascular complications.

Keywords

• Diabetes Mellitus
• Macrovascular Complications
• HbA1c

Makrovasküler Komplikasyon Gelişen Diyabetik Hastalarda Risk Faktörlerinin Değerlendirilmesi

Abstract

Amaç: Biz çalışmamızda 2015-2018 yılları arasında hastanemize diyabetes mellitusun makrovasküler komplikasyonlarından olan akut miyokard infarktüsü veya serebrovasküler olay tanısı konulan hastaların risk faktörleri açısından araştırılmasını planladık. Gereç ve Yöntemler: Retrospektif olarak yapılan çalışmaya 48 diyabetes mellitus tanılı makrovasküler komplikasyon gelişen hasta alınmış iken kontrol grubu olarak da polikliniğimizden takipli makrovasküler komplikasyon gelişmemiş olan 97 diyabetik hasta çalışmaya dahil edilmiştir. Komplikasyon gelişen hastaların ve kontrol grubu hastaların son 6 ayındaki polikliniğimize olan başvurusunda laboratuar sonuçları incelenerek yaş, BMİ, açlık kan şekeri, Hba1C, MPV, RDW, PLT ve kreatinin parametrelerine göre risk faktörleri belirlenmeye çalışıldı. İstatistiksel analizler SPSS versiyon 17.0 programı ile gerçekleştirilmiştir. Değişkenlerin normal dağılıma uygunluğu histogram grafikleri ve Kolmogorov-Smirnov testi ile normal dağılım gösteren (parametrik) değişkenlerin gruplar arasında değerlendirilirken; bağımsız gruplarda T Testi, normal dağılım göstermeyenler (non parametrik) gruplar arasında değerlendirilirken Mann Whitney U Testi kullanılmıştır. Bulgular: Yaptığımız çalışma sonucunda diyabetik hastalarda makrovasküler komplikasyon gelişimi ile yaştaki artışın, HbA1c düzeyindeki progresyonun, MPV değerinin >11,9 ve kreatinin düzeylerinin 1.2 mg/dl dğerinin üzerinde olması durumuyla istatistiksel olarak anlamlı bir ilişki saptadık fakat cinsiyet, BMI, açlık kan şekeri, RDW ve platelet değerleri her iki grupta benzer olarak bulundu. Sonuç: Elde edilen veriler doğrultusunda diyabetik hastaların takiplerinde ileri yaş, MPV,kreatinin, Hba1c değerlerinin yakın takibinin yapılması ve bu parametrelerdeki bozulmaların makrovasküler komplikasyon gelişimi açısından bize yol gösterebileceğini düşünmekteyiz.

Keywords

• Diyabetes Mellitus
• Makrovasküler Komplikasyonlar
• HbA1c

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