Malezya’da Bitkilerin Erkek Doğurganlık Arttırıcı Özelliklerine Yönelik Hayvan Çalışmaları: Son 16 Yılın Bir Değerlendirmesi
Year 2017,
Volume: 1 Issue: 1, 17 - 23, 06.06.2017
Redzuan Nul Hakim Abdul Razak
Muhammad Lokman Md Isa
,
Afzan Mat Yusof
,
Azantee Yazmie Abdul Wahab
Hussin Muhammad
Roszaman Ramli
Abstract
İnfertilite, ulusal ve küresel önemi olan ciddi bir halk sağlığı konusudur. İnfertilite prevalansının artıyor olması endişe
verici bir senaryodur. Doğal ürünlerden erkeklerde fertiliteyi arttırıcı ajanlar arayışında bitki kökenli ilaçların önemi uzun
bir süredir bilinmektedir. Bu çalışma, erkek fertilite verimliliğini arttıran çeşitli bitki araştırmaları yaklaşımlarını özetlemektedir
ki bu çalışılmaların bir kısmında bitkiler bizzat kullanılmıştır, bazılarında bitkiden bileşiklerin izole edilmesi için
ekstrakt elde edilmiştir, diğer bir kısmı ise farklı hayvan modellerinde denenen aktik bileşiklerdir. Araştırılan literatür,
2000’li yıllardan 2016’ya 16 yıllık çalışmaları kapsamakta olup bunlarda yaklaşık 12 bitkinin erkek fertilite aktivitesine
etkilerini gösterilmiştir. Sonuç olarak, bu araştırma, dünyadaki erkeklerde doğurganlık sorununu iyileştirmede gelecekteki
bitki uyumu keşfi ne odaklanmada diğer araştırmacılara yardımcı olacaktır.
References
- 1. Nada EA, El Taieb MA, Ibrahim HM, Al Saied AE. Effi cacy of tamoxifen
References and l-carnitine on sperm ultra structure and seminal oxidative
stres in patients with idiopathic oligoasthenoteratozoospermia.
Andrologia. 2015;47(7):801-10.
- 2. Dasuki M, Wan M, Hasnan J, Siti Amrah S, D’Souza U. Effetcs
of 50% ethanolic extract of Andrographis paniculata on sexual
behavior and serum hormonal assay in male Sprague Dawley
rats. International Journal of Applied Biology and Pharmaceutical
Technology. 2015;6(1):165–171.
- 3. Kenjale R, Shah R, Sathaye S. Effects of Chlorophytum borivilianum
on sexual behaviour and sperm count in Male mats. Phytotherpy
Research. 2008;22:796–801.
- 4. Giribabu N, Kumar KE, Rekha SS, Muniandy S, Salleh, N.
Chlorophytum borivilianum (Safed Musli) root extract prevents
impairment in characteristics and elevation of oxidative stress in
sperm of streptozotocin-induced adult male diabetic Wistar rats.
BMC Complementary and Alternative Medicine. 2014;14(1):291.
- 5. Ang, HH, Cheang HS, Ahmad Pauzi MY. Effects of Eurycoma
longifolia jack (Tongkat Ali) on the initiation of sexual performance
of inexperienced castrated male rats. Experimental Animals /
Japanese Association for Laboratory Animal Science. 2000; 49(1):
35–38.
- 6. Mahanem MN, Abu Hassan Shaari MN, Lukman CH. The Effect
of Eurycoma Longifolia Jack (Tongkat Ali) on Sexual Behaviour
and Sperm Quality in Rats. Malaysian Journal of Pharmaceutical
Sciences. 2004;2(1):53–60.
- 7. Chan KL, Low BS, Teh CH, Das PK. The effect of Eurycoma longifolia
on sperm quality of male rats. Natural Product Communications.
2009;4(10):1331–1336.
- 8. Norhazlina, AW, Norfi lza MM, Wan Nurul Heriza AH, Das S. The
effect of Eurycoma longifolia Jack on spermatogenesis in estrogentreated
rats. Clinics. 2010;65(1):93–98.
- 9. Low BS, Das PK, Chan KL. Standardized quassinoid-rich Eurycoma
longifolia extract improved spermatogenesis and fertility in
male rats via the hypothalamic-pituitary-gonadal axis. Journal of
Ethnopharmacology. 2013;145(3):706–714.
- 10. Amal Salem Farag M, Mahanem MN. Comparative study on the
effect of Eurycoma longifolia and Smilax myosotifl ora on male rats
fertility. AIP Conference Proceedings. 2013;1571:227–233.
- 11. Nurdiana S, Mohd Idzham AZ, Zanariah A, Mohd Luqman Hakim
MN. Effect of Ficus deltoidea leaves extracts on blood clotting,
sperm quality and testosterone level in alloxan-induced male
diabetic rats. International Journal of Pharmaceutical Sciences
Review and Research. 2011;13(1):111–114.
- 12. Samsulrizal N, Awang Z, MohdNajib MLH, Idzham M, Zarin A. Effect
of Ficus deltoidea leaves extracts on sperm quality, LDH-C 4 activity
and testosterone level in alloxan-induced male diabetic rats. IEEE
Colloquium on Humanities, Science and Engineering. 2011. http://
doi.org/10.1109/CHUSER.2011.6163864
- 13. Hakim P, Halimah AS, Mahanem MN. Effects of Gynura procumbens
extract and glibenclamide on sperm quality and specifi c activity of
testicular lactate dehydrogenase in streptozotocin-induced diabetic
rats. Malaysian Journal of Biochemistry and Molecular Biology.
2008;16(2):10–14.
- 14. Muhd Hanis MI, Siti Balkis B, Mohamad O, Jamaludin M. Protective
role of Hibiscus sabdariffa calyx extract against streptozotocin
induced sperm damage in diabetic rats. EXCLI Journal.
2012;11:659–669.
- 15. Farid AA, Mahanem MN. Ethanol extract of dragon fruit and
its effects on sperm quality and histology of the testes in mice.Biomedical Research. 2010;21(2):126–130.
- 16. Nor-Raidah R, Mahanem MN. Enhancement of fertility and
libido in male sprague dawley rats following the administration
of aqueous extract of Lunasia amara. Malaysian Applied Biology.
2015;44(1):125–131.
- 17. Mohamad Syamsudin MD, Wan Mastura SM, Arifah AK, Fuzina
NH. Effect of short-term ingestion of the methanolic extract of
Mitragyna speciosa on sperm quality in mice. In Seminar on
Veterinary Sciences. 2011:51–57.
- 18. Saheera K, Munirah S, Suzanah AR. Effects on mouse
spermatogenesis and DNA fragmentation following exposure to
cyclophosphamide and thymoquinone. European International
Journal of Science and Technology. 2013;2(7):119–136.
- 19. Suzanah AR, Noor Faridah SD, Shaik Sadak B, Saheera K. Protective
effect of black seed Nigella sativa (L.) against cyclophosphamideinduced
toxicity on reproductive and acrosomal function in mice.
- Middle East Journal of Scientifi c Research. 2013;17(7):955–964.
20. Suzanah AR, Norul Athirah MA, Shaik Sadak B, Saheera K. Impact
of thymoquinone supplementation on immobilisation stressinduced
changes in reproductive characteristics of male mice.
Journal of Applied and Natural Science. 2014;6(1):1–5.
- 21. Lina S, Hashida NH, Eliza H. Role of Habbatus sauda towards the
histological features of nicotine treated male rats seminal vesicle
and prostate gland. Biomedical Research. 2014; 25(1):11–18.
- 22. Ping NC, Noor Hashida H, Durriyyah Sharifah HA. Effects of Nigella
sativa (Habbatus sauda) oil and nicotine chronic treatments on
sperm parameters and testis histological features of rats. EvidenceBased
Complementary and Alternative Medicine. 2014:1–7.
- 23. Assi MA, Hezmee MNM, Abba Y, Rajion MA, Wahid H, Yusof
MSM. Assessment of therapeutic effects of Nigella sativa against
chronic lead acetate-induced reproductive dysfunction in male
Sprague-Dawley rats. Comparative Clinical Pathology. 2016 http://
doi.org/10.1007/s00580-016-2349-3.
- 24. Parhizkar S, Maryam Jamielah Y, Mohammad Aziz D. Effect
of Phaleria macrocarpa on sperm characteristics in adult rats.
Advanced Pharmaceutical Bulletin. 2013;3(2):345–352.
- 25. Parhizkar S, Suriani BZ, Mohammad Aziz D. Testicular morphology
of male rats exposed to Phaleria macrocarpa (Mahkota dewa)
aqueous extract. Iranian Journal of Basic Medical Sciences.
2014;17:384–390.
- 26. Noor H, Juing M, Chee BJ, Kueh BL, Zolkepli O. Medicinal
properties of Plantago major: Hypoglycaemic and male fertility
studies. Pertanika J. Trp. Agric. Sci. 2000;23(1):29–35.
- 27. Mocé, E, Graham JK. In vitro evaluation of sperm quality. Animal
Reproduction Science. 2008;105(1–2):104–118.
Animal Studies on Male Fertility Enhancing Properties of Plants In Malaysia: A Review of The Past 16 Years
Year 2017,
Volume: 1 Issue: 1, 17 - 23, 06.06.2017
Redzuan Nul Hakim Abdul Razak
Muhammad Lokman Md Isa
,
Afzan Mat Yusof
,
Azantee Yazmie Abdul Wahab
Hussin Muhammad
Roszaman Ramli
Abstract
Infertility is an issue of global and national public health concern. It is a worrying scenario with increasing number of
prevalence in infertility. The importance of drugs of plant origin in the quest of fertility enhancing agents for the male
from natural products has long been recognized. The present review is an attempt to summarize the fertility enhancing
plants with various approaches which are: part of plant have been used, type of extract for isolating the compounds,
different isolated compounds (active principles) along with different animal model used. The literature covered is of
16 years from 2000 to 2016 for around 12 plants showing improving fertility activity in males. In conclusion, this
review will help other researchers in focusing future herb based drug discovery in improving fertility problem among
male across the globe
References
- 1. Nada EA, El Taieb MA, Ibrahim HM, Al Saied AE. Effi cacy of tamoxifen
References and l-carnitine on sperm ultra structure and seminal oxidative
stres in patients with idiopathic oligoasthenoteratozoospermia.
Andrologia. 2015;47(7):801-10.
- 2. Dasuki M, Wan M, Hasnan J, Siti Amrah S, D’Souza U. Effetcs
of 50% ethanolic extract of Andrographis paniculata on sexual
behavior and serum hormonal assay in male Sprague Dawley
rats. International Journal of Applied Biology and Pharmaceutical
Technology. 2015;6(1):165–171.
- 3. Kenjale R, Shah R, Sathaye S. Effects of Chlorophytum borivilianum
on sexual behaviour and sperm count in Male mats. Phytotherpy
Research. 2008;22:796–801.
- 4. Giribabu N, Kumar KE, Rekha SS, Muniandy S, Salleh, N.
Chlorophytum borivilianum (Safed Musli) root extract prevents
impairment in characteristics and elevation of oxidative stress in
sperm of streptozotocin-induced adult male diabetic Wistar rats.
BMC Complementary and Alternative Medicine. 2014;14(1):291.
- 5. Ang, HH, Cheang HS, Ahmad Pauzi MY. Effects of Eurycoma
longifolia jack (Tongkat Ali) on the initiation of sexual performance
of inexperienced castrated male rats. Experimental Animals /
Japanese Association for Laboratory Animal Science. 2000; 49(1):
35–38.
- 6. Mahanem MN, Abu Hassan Shaari MN, Lukman CH. The Effect
of Eurycoma Longifolia Jack (Tongkat Ali) on Sexual Behaviour
and Sperm Quality in Rats. Malaysian Journal of Pharmaceutical
Sciences. 2004;2(1):53–60.
- 7. Chan KL, Low BS, Teh CH, Das PK. The effect of Eurycoma longifolia
on sperm quality of male rats. Natural Product Communications.
2009;4(10):1331–1336.
- 8. Norhazlina, AW, Norfi lza MM, Wan Nurul Heriza AH, Das S. The
effect of Eurycoma longifolia Jack on spermatogenesis in estrogentreated
rats. Clinics. 2010;65(1):93–98.
- 9. Low BS, Das PK, Chan KL. Standardized quassinoid-rich Eurycoma
longifolia extract improved spermatogenesis and fertility in
male rats via the hypothalamic-pituitary-gonadal axis. Journal of
Ethnopharmacology. 2013;145(3):706–714.
- 10. Amal Salem Farag M, Mahanem MN. Comparative study on the
effect of Eurycoma longifolia and Smilax myosotifl ora on male rats
fertility. AIP Conference Proceedings. 2013;1571:227–233.
- 11. Nurdiana S, Mohd Idzham AZ, Zanariah A, Mohd Luqman Hakim
MN. Effect of Ficus deltoidea leaves extracts on blood clotting,
sperm quality and testosterone level in alloxan-induced male
diabetic rats. International Journal of Pharmaceutical Sciences
Review and Research. 2011;13(1):111–114.
- 12. Samsulrizal N, Awang Z, MohdNajib MLH, Idzham M, Zarin A. Effect
of Ficus deltoidea leaves extracts on sperm quality, LDH-C 4 activity
and testosterone level in alloxan-induced male diabetic rats. IEEE
Colloquium on Humanities, Science and Engineering. 2011. http://
doi.org/10.1109/CHUSER.2011.6163864
- 13. Hakim P, Halimah AS, Mahanem MN. Effects of Gynura procumbens
extract and glibenclamide on sperm quality and specifi c activity of
testicular lactate dehydrogenase in streptozotocin-induced diabetic
rats. Malaysian Journal of Biochemistry and Molecular Biology.
2008;16(2):10–14.
- 14. Muhd Hanis MI, Siti Balkis B, Mohamad O, Jamaludin M. Protective
role of Hibiscus sabdariffa calyx extract against streptozotocin
induced sperm damage in diabetic rats. EXCLI Journal.
2012;11:659–669.
- 15. Farid AA, Mahanem MN. Ethanol extract of dragon fruit and
its effects on sperm quality and histology of the testes in mice.Biomedical Research. 2010;21(2):126–130.
- 16. Nor-Raidah R, Mahanem MN. Enhancement of fertility and
libido in male sprague dawley rats following the administration
of aqueous extract of Lunasia amara. Malaysian Applied Biology.
2015;44(1):125–131.
- 17. Mohamad Syamsudin MD, Wan Mastura SM, Arifah AK, Fuzina
NH. Effect of short-term ingestion of the methanolic extract of
Mitragyna speciosa on sperm quality in mice. In Seminar on
Veterinary Sciences. 2011:51–57.
- 18. Saheera K, Munirah S, Suzanah AR. Effects on mouse
spermatogenesis and DNA fragmentation following exposure to
cyclophosphamide and thymoquinone. European International
Journal of Science and Technology. 2013;2(7):119–136.
- 19. Suzanah AR, Noor Faridah SD, Shaik Sadak B, Saheera K. Protective
effect of black seed Nigella sativa (L.) against cyclophosphamideinduced
toxicity on reproductive and acrosomal function in mice.
- Middle East Journal of Scientifi c Research. 2013;17(7):955–964.
20. Suzanah AR, Norul Athirah MA, Shaik Sadak B, Saheera K. Impact
of thymoquinone supplementation on immobilisation stressinduced
changes in reproductive characteristics of male mice.
Journal of Applied and Natural Science. 2014;6(1):1–5.
- 21. Lina S, Hashida NH, Eliza H. Role of Habbatus sauda towards the
histological features of nicotine treated male rats seminal vesicle
and prostate gland. Biomedical Research. 2014; 25(1):11–18.
- 22. Ping NC, Noor Hashida H, Durriyyah Sharifah HA. Effects of Nigella
sativa (Habbatus sauda) oil and nicotine chronic treatments on
sperm parameters and testis histological features of rats. EvidenceBased
Complementary and Alternative Medicine. 2014:1–7.
- 23. Assi MA, Hezmee MNM, Abba Y, Rajion MA, Wahid H, Yusof
MSM. Assessment of therapeutic effects of Nigella sativa against
chronic lead acetate-induced reproductive dysfunction in male
Sprague-Dawley rats. Comparative Clinical Pathology. 2016 http://
doi.org/10.1007/s00580-016-2349-3.
- 24. Parhizkar S, Maryam Jamielah Y, Mohammad Aziz D. Effect
of Phaleria macrocarpa on sperm characteristics in adult rats.
Advanced Pharmaceutical Bulletin. 2013;3(2):345–352.
- 25. Parhizkar S, Suriani BZ, Mohammad Aziz D. Testicular morphology
of male rats exposed to Phaleria macrocarpa (Mahkota dewa)
aqueous extract. Iranian Journal of Basic Medical Sciences.
2014;17:384–390.
- 26. Noor H, Juing M, Chee BJ, Kueh BL, Zolkepli O. Medicinal
properties of Plantago major: Hypoglycaemic and male fertility
studies. Pertanika J. Trp. Agric. Sci. 2000;23(1):29–35.
- 27. Mocé, E, Graham JK. In vitro evaluation of sperm quality. Animal
Reproduction Science. 2008;105(1–2):104–118.