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Microbiota and Infl ammatory Rheumatic Diseases

Year 2017, - Mikrobiyota, 109 - 114, 15.11.2017

Abstract

In recent years, microbiomic and microbiota terms are frequently used. Relationship between microorganisms and the host can be studied by microbiomic studies. It was aimed to determine by human microbiology project initiated with 300 volunteers in 2007 and to investigate whether human microbiomic changes can be related to diseases. Just like genomics, the number of microorganisms in the human body is 10 times higher than the number of human cells. That is, a human is a holobiont (super organism) consisting of a combination of 10% human and 90% microbial cells. Human microbiota consist of viruses, fungi and many eukaryotic microorganisms, especially bacteria, In addition, the bacterial genome in the human body is 150 times more than the human genome. Most of the human microbiota is colonized in the gut, genitourinary system and respiratory system, especially in the digestive system. The colon alone contains more than 70% of the microorganisms in our body. Microbiota has an important role in human, illness and health. In this case, microbiota can be thought of as an obscured organ. Primarily the intestinal microbiota, provide the necessary signals by promoting immune cell maturation and normal development of immune system functions. Research in microbiota have opened a new page in rheumatology. In recent years, the microbiota structure of the intestines, urogenital, and respiratory tracts has become more understandable in relation to inflammatory rheumatic diseases.

References

  • 1. Yılmaz K, Altındiş M. Sindirim sistemi mikrobiyotası ve fekal transplantasyon. Nobel Med 2017; 13(1):9-15.
  • 2. Turnbaugh PJ, Hamady M, Yatsunenko T, Cantarel BL, Duncan A, Ley RE, Sogin ML, Jones WJ, Roe BA, Affourtit JP, et al. A core gut microbiome in obese and lean twins. Nature. 2009;457:480–484.
  • 3. Manichanh C, Borruel N, Casellas F, Guarner F. The gut microbiota in IBD. Nat Rev Gastroenterol Hepatol. 2012;9:599–608.
  • 4. Turnbaugh PJ, Ley RE, Hamady M, Fraser-Liggett CM, Knight R, Gordon JI. The human microbiome project. Nature. 2007; 449:804–10.
  • 5. Morgan XC, Tickle TL, Sokol H, et al. Dysfunction of the intestinal microbiome in infl ammatory bowel disease and treatment. Genome biology. 2012; 13:R79. [PubMed: 23013615] 22.
  • 6. C. Mackay. SP0178 (2017) GUT DYSBIOSIS AND OTHER CHALLENGES PRECIPITATE ARTHRITIS. Citation: Annals of the Rheumatic Diseases, volume 76, supplement 2, year 2017, page 43. Session: How diet infl uences musculoskeletal diseases , (Speaker Presentations).
  • 7. Warden CC. The Toxemic Factor in Rheumatoid Arthritis. Cal State J Med. 1909; 7:299–301.
  • 8. Reis BS, Hoytema van Konijnenburg DP, Grivennikov SI, Mucida D. Transcription factor T-bet regulates intraepithelial lymphocyte functional maturation. Immunity. 2014;41:244–256.
  • 9. Scher JU, Ubeda C, Equinda M, et al. Periodontal disease and the oral microbiota in new-onset rheumatoid arthritis. Arthritis and rheumatism. 2012; 64:3083–94.
  • 10. Demoruelle MK, Weisman MH, Simonian PL, et al. Brief report: airways abnormalities and rheumatoid arthritis-related autoantibodies in subjects without arthritis: early injury or initiating site of autoimmunity? Arthritis and rheumatism. 2012; 64:1756– 61.
  • 11. Kohashi O, Kohashi Y, Takahashi T, Ozawa A, Shigematsu N. Reverse effect of gram-positive bacteria vs. gram-negative bacteria on adjuvant-induced arthritis in germfree rats. Microbiol Immunol. 1985; 29:487–97.
  • 12. Caccese RG, Zimmerman JL, Carlson RP. Bacterial lipopolysaccharide potentiates type II collagen-induced arthritis in mice. Mediators of infl ammation. 1992; 1:273–9.
  • 13. Gomez A, Luckey D, Yeoman CJ, et al. Loss of sex and age driven differences in the gut microbiome characterize arthritis-susceptible 0401 mice but not arthritis-resistant 0402 mice. PloS one. 2012; 7:e36095.
  • 14. Eerola E, Mottonen T, Hannonen P, et al. Intestinal fl ora in early rheumatoid arthritis. Br J Rheumatol. 1994; 33:1030–8.
  • 15. Stoll ML. Gut microbes, immunity and spondylarthritis. Clin Immunol. 2015 Aug;159(2):134-42.
  • 16. Arvikar SL, Fisher MC. Infl ammatory bowel disease associated arthropathy. Current reviews in musculoskeletal medicine. 2011; 4:123–31.
  • 17. Hammer RE, Maika SD, Richardson JA, Tang JP, Taurog JD. Spontaneous infl ammatory disease in transgenic rats expressing HLA-B27 and human beta 2m: an animal model of HLAB27associated human disorders. Cell. 1990; 63:1099–112.
  • 18. Glatigny S, Fert I, Blaton MA, et al. Proinfl ammatory Th17 cells are expanded and induced by dendritic cells in spondylarthritisprone HLA-B27-transgenic rats. Arthritis and rheumatism. 2012; 64:110–20.
  • 19. Rath HC, Herfarth HH, Ikeda JS, Grenther WB, Hamm TE, Jr, Balish E, Taurog JD, Hammer RE, Wilson KH, Sartor RB. Normal luminal bacteria, especially Bacteroides species, mediate chronic colitis, gastritis, and arthritis in HLA-B27/human beta2 microglobulin transgenic rats. J Clin Invest. 1996;98:945–953.
  • 20. Van Praet L, Van den Bosch FE, Jacques P, et al. Microscopic gut infl ammation in axial spondyloarthritis: a multiparametric predictive model. Annals of the rheumatic diseases. 2013; 72:414–7).
  • 21. Stoll ML, Kumar R, Morrow CD, et al. Altered microbiota associated with abnormal humoral immune responses to commensal organisms in enthesitis-related arthritis. Arthritis research & therapy. 2014; 16:486).
  • 22. Stebbings S, Munro K, Simon MA, Tannock G, Highton J, Harmsen H, Welling G, Seksik P, Dore J, Grame G, et al. Comparison of the faecal microfl ora of patients with ankylosing spondylitis and controls using molecular methods of analysis. Rheumatology (Oxford) 2002;41:1395–1401.].
  • 23. Singh YP, Singh AK, Aggarwal A, Misra R. Evidence of cellular immune response to outer membrane protein of Salmonella typhimurium in patients with enthesitis-related arthritis subtype of juvenile idiopathic arthritis. J Rheumatol. 2011;38:161–166.
  • 24. Gill T, Asquith M, Rosenbaum JT, Colbert RA. The intestinal microbiome in spondyloarthritis. Curr Opin Rheumatol. 2015 Jul;27(4):319-25).
  • 25. Scher JU, Ubeda C, Artacho A, et al. Decreased bacterial diversity characterizes the altered gut microbiota in patients with psoriatic arthritis, resembling dysbiosis in infl ammatory bowel disease. Arthritis & rheumatology. 2015; 67:128–39.
  • 26. Dethlefsen L, Relman DA. Incomplete recovery and individualized responses of the human distal gut microbiota to repeated antibiotic perturbation. Proceedings of the National Academy of Sciences of the United States of America. 2011; 108(Suppl 1):4554–61.).
  • 27. Hoentjen F, Welling GW, Harmsen HJ, Zhang X, Snart J, Tannock GW, Lien K, Churchill TA, Lupicki M, Dieleman LA. Reduction of colitis by prebiotics in HLA-B27 transgenic rats is associated with microfl ora changes and immunomodulation. Infl amm Bowel Dis. 2005;11:977–985.].
  • 28. van Nood E, Vrieze A, Nieuwdorp M, et al. Duodenal infusion of donor feces for recurrent Clostridium diffi cile. The New England journal of medicine. 2013; 368:407–15.
  • 29. (Colman RJ, Rubin DT. Fecal microbiota transplantation as therapy for infl ammatory bowel disease: a systematic review and metaanalysis. Journal of Crohn’s & colitis. 2014; 8:1569–81.

İnflamatuvar Romatizmal Hastalıklar ve Mikrobiyota

Year 2017, - Mikrobiyota, 109 - 114, 15.11.2017

Abstract

Son yıllarda mikrobiyom ve mikrobiyota terimleri sıklıkla kullanılmaktadır. Mikroorganizmalar arası ve mikroorganizma ile konak arasındaki ilişkiler, mikrobiyom çalışmaları ile incelenmektedir. 2007 yılında 300 gönüllü ile başlatılan insan mikrobiyom projesi ile insan vücudundaki tüm mikroorganizmaları belirlemek, insan mikrobiyom değişikliklerinin hastalıklarla ilişkilendirilip ilişkilendirilemeyeceğini araştırmak hedefl enmiştir. İnsan mikrobiyotası; başta bakteriler olmak üzere, virüsler, mantarlar ve birçok ökaryotik mikroorganizmalardan oluşmaktadır. Ayrıca insan vücudundaki bakteri genomu, insan genonumdan 150 kat daha fazladır. Tıpkı genom olarak üstünlükleri gibi, insan vücudundaki mikroorganizma sayısı da insan hücre sayısından 10 kat fazladır. Yani insan, %10 insan ve %90 mikrobiyal hücrelerin birleşiminden oluşan bir holobiont (süperorganizma)’tur. İnsan mikrobiyotasının büyük kısmı, başta sindirim sistemi olmak üzere deri, genitoüriner sistem ve solunum sisteminde kolonize olmuştur. Kolon, tek başına vücudumuzdaki mikroorganizmaların %70’inden fazlasını barındırmaktadır. Mikrobiyotanın insanda, hastalık ve sağlık durumlarında önemli rolü mevcuttur. Bu durumda mikrobiyota, gözardı edilmiş bir organ gibi düşünülebilir. Başta intestinal mikrobiyota olmak üzere insanda mikrobiyota, hastalık ve sağlık durumlarını, bağışıklık hücrelerinin olgunlaşmasını ve bağışıklık sistem fonksiyonlarının normal gelişimini teşvik ederek gerekli sinyalleri sağlar. Mikrobiyota ile ilgili bilimsel veriler romatolojiye yeni bir sayfa açmıştır. Son yıllarda başta bağırsak, ürogenital, solunum yollarının mikrobiyota yapısının inflamatuvar romatizmal hastalıklarla ilişkisi daha çok anlaşılır olmuştur.

References

  • 1. Yılmaz K, Altındiş M. Sindirim sistemi mikrobiyotası ve fekal transplantasyon. Nobel Med 2017; 13(1):9-15.
  • 2. Turnbaugh PJ, Hamady M, Yatsunenko T, Cantarel BL, Duncan A, Ley RE, Sogin ML, Jones WJ, Roe BA, Affourtit JP, et al. A core gut microbiome in obese and lean twins. Nature. 2009;457:480–484.
  • 3. Manichanh C, Borruel N, Casellas F, Guarner F. The gut microbiota in IBD. Nat Rev Gastroenterol Hepatol. 2012;9:599–608.
  • 4. Turnbaugh PJ, Ley RE, Hamady M, Fraser-Liggett CM, Knight R, Gordon JI. The human microbiome project. Nature. 2007; 449:804–10.
  • 5. Morgan XC, Tickle TL, Sokol H, et al. Dysfunction of the intestinal microbiome in infl ammatory bowel disease and treatment. Genome biology. 2012; 13:R79. [PubMed: 23013615] 22.
  • 6. C. Mackay. SP0178 (2017) GUT DYSBIOSIS AND OTHER CHALLENGES PRECIPITATE ARTHRITIS. Citation: Annals of the Rheumatic Diseases, volume 76, supplement 2, year 2017, page 43. Session: How diet infl uences musculoskeletal diseases , (Speaker Presentations).
  • 7. Warden CC. The Toxemic Factor in Rheumatoid Arthritis. Cal State J Med. 1909; 7:299–301.
  • 8. Reis BS, Hoytema van Konijnenburg DP, Grivennikov SI, Mucida D. Transcription factor T-bet regulates intraepithelial lymphocyte functional maturation. Immunity. 2014;41:244–256.
  • 9. Scher JU, Ubeda C, Equinda M, et al. Periodontal disease and the oral microbiota in new-onset rheumatoid arthritis. Arthritis and rheumatism. 2012; 64:3083–94.
  • 10. Demoruelle MK, Weisman MH, Simonian PL, et al. Brief report: airways abnormalities and rheumatoid arthritis-related autoantibodies in subjects without arthritis: early injury or initiating site of autoimmunity? Arthritis and rheumatism. 2012; 64:1756– 61.
  • 11. Kohashi O, Kohashi Y, Takahashi T, Ozawa A, Shigematsu N. Reverse effect of gram-positive bacteria vs. gram-negative bacteria on adjuvant-induced arthritis in germfree rats. Microbiol Immunol. 1985; 29:487–97.
  • 12. Caccese RG, Zimmerman JL, Carlson RP. Bacterial lipopolysaccharide potentiates type II collagen-induced arthritis in mice. Mediators of infl ammation. 1992; 1:273–9.
  • 13. Gomez A, Luckey D, Yeoman CJ, et al. Loss of sex and age driven differences in the gut microbiome characterize arthritis-susceptible 0401 mice but not arthritis-resistant 0402 mice. PloS one. 2012; 7:e36095.
  • 14. Eerola E, Mottonen T, Hannonen P, et al. Intestinal fl ora in early rheumatoid arthritis. Br J Rheumatol. 1994; 33:1030–8.
  • 15. Stoll ML. Gut microbes, immunity and spondylarthritis. Clin Immunol. 2015 Aug;159(2):134-42.
  • 16. Arvikar SL, Fisher MC. Infl ammatory bowel disease associated arthropathy. Current reviews in musculoskeletal medicine. 2011; 4:123–31.
  • 17. Hammer RE, Maika SD, Richardson JA, Tang JP, Taurog JD. Spontaneous infl ammatory disease in transgenic rats expressing HLA-B27 and human beta 2m: an animal model of HLAB27associated human disorders. Cell. 1990; 63:1099–112.
  • 18. Glatigny S, Fert I, Blaton MA, et al. Proinfl ammatory Th17 cells are expanded and induced by dendritic cells in spondylarthritisprone HLA-B27-transgenic rats. Arthritis and rheumatism. 2012; 64:110–20.
  • 19. Rath HC, Herfarth HH, Ikeda JS, Grenther WB, Hamm TE, Jr, Balish E, Taurog JD, Hammer RE, Wilson KH, Sartor RB. Normal luminal bacteria, especially Bacteroides species, mediate chronic colitis, gastritis, and arthritis in HLA-B27/human beta2 microglobulin transgenic rats. J Clin Invest. 1996;98:945–953.
  • 20. Van Praet L, Van den Bosch FE, Jacques P, et al. Microscopic gut infl ammation in axial spondyloarthritis: a multiparametric predictive model. Annals of the rheumatic diseases. 2013; 72:414–7).
  • 21. Stoll ML, Kumar R, Morrow CD, et al. Altered microbiota associated with abnormal humoral immune responses to commensal organisms in enthesitis-related arthritis. Arthritis research & therapy. 2014; 16:486).
  • 22. Stebbings S, Munro K, Simon MA, Tannock G, Highton J, Harmsen H, Welling G, Seksik P, Dore J, Grame G, et al. Comparison of the faecal microfl ora of patients with ankylosing spondylitis and controls using molecular methods of analysis. Rheumatology (Oxford) 2002;41:1395–1401.].
  • 23. Singh YP, Singh AK, Aggarwal A, Misra R. Evidence of cellular immune response to outer membrane protein of Salmonella typhimurium in patients with enthesitis-related arthritis subtype of juvenile idiopathic arthritis. J Rheumatol. 2011;38:161–166.
  • 24. Gill T, Asquith M, Rosenbaum JT, Colbert RA. The intestinal microbiome in spondyloarthritis. Curr Opin Rheumatol. 2015 Jul;27(4):319-25).
  • 25. Scher JU, Ubeda C, Artacho A, et al. Decreased bacterial diversity characterizes the altered gut microbiota in patients with psoriatic arthritis, resembling dysbiosis in infl ammatory bowel disease. Arthritis & rheumatology. 2015; 67:128–39.
  • 26. Dethlefsen L, Relman DA. Incomplete recovery and individualized responses of the human distal gut microbiota to repeated antibiotic perturbation. Proceedings of the National Academy of Sciences of the United States of America. 2011; 108(Suppl 1):4554–61.).
  • 27. Hoentjen F, Welling GW, Harmsen HJ, Zhang X, Snart J, Tannock GW, Lien K, Churchill TA, Lupicki M, Dieleman LA. Reduction of colitis by prebiotics in HLA-B27 transgenic rats is associated with microfl ora changes and immunomodulation. Infl amm Bowel Dis. 2005;11:977–985.].
  • 28. van Nood E, Vrieze A, Nieuwdorp M, et al. Duodenal infusion of donor feces for recurrent Clostridium diffi cile. The New England journal of medicine. 2013; 368:407–15.
  • 29. (Colman RJ, Rubin DT. Fecal microbiota transplantation as therapy for infl ammatory bowel disease: a systematic review and metaanalysis. Journal of Crohn’s & colitis. 2014; 8:1569–81.
There are 29 citations in total.

Details

Subjects Health Care Administration
Journal Section Review
Authors

İbrahim Tekeoğlu

Publication Date November 15, 2017
Acceptance Date September 20, 2017
Published in Issue Year 2017 - Mikrobiyota

Cite

AMA Tekeoğlu İ. Microbiota and Infl ammatory Rheumatic Diseases. J Biotechnol and Strategic Health Res. November 2017;1:109-114.

Journal of Biotechnology and Strategic Health Research