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Microbiota and Cancer

Year 2017, - Mikrobiyota, 123 - 131, 15.11.2017

Abstract

Cancer is a major public health problem. Today, despite the very important developments in oncology, cancer is still not in the category of curative diseases. However, signifi cant steps are being taken in this direction by the identifi cation of factors that play a role in the stages of complex carcinogenesis. Recent data from the human microbiology project have shown that commensal microorganism species living on the epithelial surfaces of the body play an active role in this process and are also associated with personal responses to cancer treatment and toxicity. As a result, further exposure of a major factor with key roles in cancer development and treatment stages will reduce personal, social and economic losses associated with cancer. We aimed to assess the role of microbiota in carcinogenesis and their effects on response to cancer treatments and toxicity, based on the data obtained from recent studies in this review.

References

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Mikrobiyota ve Kanser

Year 2017, - Mikrobiyota, 123 - 131, 15.11.2017

Abstract

Kanser, önemli bir halk sağlığı sorunudur. Günümüzde, onkoloji alanındaki çok önemli gelişmelere rağmen halen kanser küratif hastalıklar kategorisinde değildir. Ancak, kompleks karsinogenez aşamalarında rol oynayan faktörlerin saptanması ile bu yolda önemli adımlar atılmaktadır. İnsan Mikrobiyota projesi kapsamında son dönemde elde edilen veriler, vücudumuzun epitelyal yüzeylerinde yaşayan kommensal mikroorganizma türlerinin bu süreçte aktif rol aldığını, aynı zamanda kanser tedavisine verilen kişisel yanıtlar ve toksisite ile de ilişkili olduğunu göstermiştir. Sonuç olarak, kanser oluşumu ve tedavisi aşamalarında anahtar role sahip major bir faktörün daha ortaya çıkarılması, kansere bağlı kişisel, toplumsal ve ekonomik kayıpları azaltacaktır. Biz, bu derlemede, yakın zamanda yapılan çalışmalardan elde edilen verilere dayanılarak, Mikrobiyotanın, karsinogenezdeki rolünü ve kanser tedavilerine yanıt ve toksisite üzerine etkilerini değerlendirmeyi amaçladık.

References

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  • 2. Xu Z, Knight R. Dietary effects on human gut microbiome diversity. The British journal of nutrition. 2015;113 Suppl:S1-5.
  • 3. Dzutsev A, Goldszmid RS, Viaud S, Zitvogel L, Trinchieri G. The role of the microbiota in infl ammation, carcinogenesis, and cancer therapy. European journal of immunology. 2015;45(1):17-31.
  • 4. Clarke G, Stilling RM, Kennedy PJ, Stanton C, Cryan JF, Dinan TG. Minireview: Gut microbiota: the neglected endocrine organ. Molecular endocrinology (Baltimore, Md). 2014;28(8):1221-38.
  • 5. Gerritsen J, Smidt H, Rijkers GT, de Vos WM. Intestinal microbiota in human health and disease: the impact of probiotics. Genes & nutrition. 2011;6(3):209-40.
  • 6. Sandek A, Bauditz J, Swidsinski A, Buhner S, Weber-Eibel J, von Haehling S, et al. Altered intestinal function in patients with chronic heart failure. Journal of the American College of Cardiology. 2007;50(16):1561-9.
  • 7. Fuentealba C, Figuerola F, Estévez AM, Bastías JM, Muñoz O. Bioaccessibility of lignans from fl axseed (Linum usitatissimum L.) determined by singleβbatch in vitro simulation of the digestive process. Journal of the science of food and agriculture. 2014;94(9):1729-38.
  • 8. de Martel C, Ferlay J, Franceschi S, Vignat J, Bray F, Forman D, et al. Global burden of cancers attributable to infections in 2008: a review and synthetic analysis. The Lancet Oncology. 2012;13(6):607-15.
  • 9. Turnbaugh PJ, Ley RE, Hamady M, Fraser-Liggett CM, Knight R, Gordon JI. The human microbiome project. Nature. 2007;449(7164):804-10.
  • 10. Roy S, Trinchieri G. Microbiota: a key orchestrator of cancer therapy. Nature reviews Cancer. 2017;17(5):271-85.
  • 11. Bhatt AP, Redinbo MR, Bultman SJ. The role of the microbiome in cancer development and therapy. CA: a cancer journal for clinicians. 2017;67(4):326-44.
  • 12. Belkaid Y, Hand TW. Role of the microbiota in immunity and infl ammation. Cell. 2014;157(1):121-41.
  • 13. De Santis S, Cavalcanti E, Mastronardi M, Jirillo E, Chieppa M. Nutritional Keys for Intestinal Barrier Modulation. Frontiers in immunology. 2015;6:612.
  • 14. Peterson LW, Artis D. Intestinal epithelial cells: regulators of barrier function and immune homeostasis. Nature reviews Immunology. 2014;14(3):141-53.
  • 15. Singh N, Gurav A, Sivaprakasam S, Brady E, Padia R, Shi H, et al. Activation of Gpr109a, receptor for niacin and the commensal metabolite butyrate, suppresses colonic infl ammation and carcinogenesis. Immunity. 2014;40(1):128-39.
  • 16. Plottel CS, Blaser MJ. Microbiome and malignancy. Cell host & microbe. 2011;10(4):324-35.
  • 17. Goldszmid RS, Trinchieri G. The price of immunity. Nature immunology. 2012;13(10):932-8.
  • 18. Larsson E, Tremaroli V, Lee YS, Koren O, Nookaew I, Fricker A, et al. Analysis of gut microbial regulation of host gene expression along the length of the gut and regulation of gut microbial ecology through MyD88. Gut. 2011:gutjnl-2011-301104.
  • 19. Smith PM, Howitt MR, Panikov N, Michaud M, Gallini CA, Bohlooly-y M, et al. The microbial metabolites, short-chain fatty acids, regulate colonic Treg cell homeostasis. Science. 2013;341(6145):569-73.
  • 20. Kalina U, Koyama N, Hosoda T, Nuernberger H, Sato K, Hoelzer D, et al. Enhanced production of ILβ18 in butyrateβtreated intestinal epithelium by stimulation of the proximal promoter region. European journal of immunology. 2002;32(9):2635-43.
  • 21. Salcedo R, Worschech A, Cardone M, Jones Y, Gyulai Z, Dai RM, et al. MyD88-mediated signaling prevents development of adenocarcinomas of the colon: role of interleukin 18. The Journal of experimental medicine. 2010;207(8):1625-36.
  • 22. Saleh M, Trinchieri G. Innate immune mechanisms of colitis and colitis-associated colorectal cancer. Nature reviews Immunology. 2010;11(1):9.
  • 23. Wlodarska M, Thaiss CA, Nowarski R, Henao-Mejia J, Zhang J-P, Brown EM, et al. NLRP6 infl ammasome orchestrates the colonic host-microbial interface by regulating goblet cell mucus secretion. Cell. 2014;156(5):1045-59.
  • 24. Mazmanian SK, Round JL, Kasper DL. A microbial symbiosis factor prevents intestinal infl ammatory disease. Nature. 2008;453(7195):620.
  • 25. Belkaid Y, Naik S. Compartmentalized and systemic control of tissue immunity by commensals. Nature immunology. 2013;14(7):646- 53.
  • 26. Chervonsky AV. Microbiota and autoimmunity. Cold Spring Harbor perspectives in biology. 2013;5(3):a007294.
  • 27. Bongers G, Pacer ME, Geraldino TH, Chen L, He Z, Hashimoto D, et al. Interplay of host microbiota, genetic perturbations, and infl ammation promotes local development of intestinal neoplasms in mice. Journal of Experimental Medicine. 2014;211(3):457-72.
  • 28. Sears CL, Garrett WS. Microbes, microbiota, and colon cancer. Cell host & microbe. 2014;15(3):317-28.
  • 29. Zackular JP, Baxter NT, Iverson KD, Sadler WD, Petrosino JF, Chen GY, et al. The gut microbiome modulates colon tumorigenesis. MBio. 2013;4(6):e00692-13.
  • 30. Mira-Pascual L, Cabrera-Rubio R, Ocon S, Costales P, Parra A, Suarez A, et al. Microbial mucosal colonic shifts associated with the development of colorectal cancer reveal the presence of different bacterial and archaeal biomarkers. Journal of gastroenterology. 2015;50(2):167-79.
  • 31. Poutahidis T, Cappelle K, Levkovich T, Lee C-W, Doulberis M, Ge Z, et al. Pathogenic intestinal bacteria enhance prostate cancer development via systemic activation of immune cells in mice. PloS one. 2013;8(8):e73933.
  • 32. Yamamoto ML, Maier I, Dang AT, Berry D, Liu J, Ruegger PM, et al. Intestinal bacteria modify lymphoma incidence and latency by affecting systemic infl ammatory state, oxidative stress, and leukocyte genotoxicity. Cancer research. 2013;73(14):4222-32.
  • 33. Westbrook AM, Wei B, Hacke K, Xia M, Braun J, Schiestl RH. The role of tumour necrosis factor-β and tumour necrosis factor receptor signalling in infl ammation-associated systemic genotoxicity. Mutagenesis. 2011;27(1):77-86.
  • 34. Sergentanis TN, Zagouri F, Zografos GC. Is antibiotic use a risk factor for breast cancer? A metaβanalysis. Pharmacoepidemiology and drug safety. 2010;19(11):1101-7.
  • 35. Kim Y-G, Udayanga KGS, Totsuka N, Weinberg JB, Núñez G, Shibuya A. Gut dysbiosis promotes M2 macrophage polarization and allergic airway infl ammation via fungi-induced PGE 2. Cell host & microbe. 2014;15(1):95-102.
  • 36. David LA, Maurice CF, Carmody RN, Gootenberg DB, Button JE, Wolfe BE, et al. Diet rapidly and reproducibly alters the human gut microbiome. Nature. 2014;505(7484):559-63.
  • 37. DeVita VT, Chu E. A history of cancer chemotherapy. Cancer research. 2008;68(21):8643-53.
  • 38. Iida N, Dzutsev A, Stewart CA, Smith L, Bouladoux N, Weingarten RA, et al. Commensal bacteria control cancer response to therapy by modulating the tumor microenvironment. Science. 2013;342(6161):967-70.
  • 39. Dzutsev A, Goldszmid RS, Viaud S, Zitvogel L, Trinchieri G. The role of the microbiota in infl ammation, carcinogenesis, and cancer therapy. European journal of immunology. 2015;45(1):17-31.
  • 40. Carmody RN, Turnbaugh PJ. Host-microbial interactions in the metabolism of therapeutic and diet-derived xenobiotics. The Journal of clinical investigation. 2014;124(10):4173.
  • 41. Haiser HJ, Turnbaugh PJ. Developing a metagenomic view of xenobiotic metabolism. Pharmacological research. 2013;69(1):21- 31.
  • 42. Björkholm B, Bok CM, Lundin A, Rafter J, Hibberd ML, Pettersson S. Intestinal microbiota regulate xenobiotic metabolism in the liver. PloS one. 2009;4(9):e6958.
  • 43. Yip LY, Chan ECY. Investigation of host-gut microbiota modulation of therapeutic outcome. Drug Metabolism and Disposition. 2015:dmd. 115.063750.
  • 44. Fujita K-i, Sparreboom A. Pharmacogenetics of irinotecan disposition and toxicity: a review. Current clinical pharmacology. 2010;5(3):209-17.
  • 45. Stringer AM, Gibson RJ, Logan RM, Bowen JM, Yeoh AS, Keefe DM. Faecal microfl ora and β-glucuronidase expression are altered in an irinotecan-induced diarrhea model in rats. Cancer biology & therapy. 2008;7(12):1919-25.
  • 46. McIntosh FM, Maison N, Holtrop G, Young P, Stevens VJ, Ince J, et al. Phylogenetic distribution of genes encoding ββglucuronidase activity in human colonic bacteria and the impact of diet on faecal glycosidase activities. Environmental microbiology. 2012;14(8):1876-87.
  • 47. Wallace BD, Wang H, Lane KT, Scott JE, Orans J, Koo JS, et al. Alleviating cancer drug toxicity by inhibiting a bacterial enzyme. Science. 2010;330(6005):831-5.
  • 48. Lehouritis P, Cummins J, Stanton M, Murphy CT, McCarthy FO, Reid G, et al. Local bacteria affect the effi cacy of chemotherapeutic drugs. Scientifi c reports. 2015;5.
  • 49. Selwyn FP, Cui JY, Klaassen CD. RNA-Seq quantifi cation of hepatic drug processing genes in germ-free mice. Drug Metabolism and Disposition. 2015;43(10):1572-80.
  • 50. Gui Q, Lu H, Zhang C, Xu Z, Yang Y. Well-balanced commensal microbiota contributes to anti-cancer response in a lung cancer mouse model. Genet Mol Res. 2015;14(2):5642-51.
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There are 73 citations in total.

Details

Subjects Health Care Administration
Journal Section Review
Authors

Ahmet Cihat Genç This is me

İlhan Hacıbekiroğlu

Publication Date November 15, 2017
Acceptance Date September 13, 2017
Published in Issue Year 2017 - Mikrobiyota

Cite

AMA Genç AC, Hacıbekiroğlu İ. Microbiota and Cancer. J Biotechnol and Strategic Health Res. November 2017;1:123-131.

Journal of Biotechnology and Strategic Health Research