Fekal Mikrobiyota Transplantasyonu (FMT)

Year 2017, - Mikrobiyota, 132 - 140, 15.11.2017

Ahmet Uygun

Abstract

Gaita nakli, Clostridium difficile infeksiyonu için önemli bir tedavi seçeneğidir. Gaita naklinin, bağırsak mikroflorasındaki değişiklikler ile ilgili diğer hastalıkların tedavisinde, rol oynayabileceği konusunda ümit verici bulgular tespit edilmiştir. Gaita nakli, bağırsak mikroflorasındaki değişiklikler ile ilgili spesifik hastalıkları tedavi etmek için, sağlıklı bir donörden alınan gaitanın, alıcı hastanın bağırsağına yerleştirilmesidir. Gaita nakli ile ilgili olarak, donör seçimi, donör taraması, yapılması gereken standart protokoller, metodlar ve uzun dönem güvenlik sonuçları dahil, cevaplanmamış bir çok soru hala vardır.

Keywords

Fekal mikrobiyota transplantasyonu, Ülseratif kolitis, Crohn Hastalığı, İrritabl bağırsak sendromu

Fecal Microbiota Transplantation (FMT)

Abstract

Fecal microbiota transplantation (FMT) is an important therapeutic option for Clostridium diffi cile infection. Promising findings suggest that FMT may play a role also in the management of other disorders associated with the alteration of gut microbiota. Fecal microbiota transplantation (FMT) consists of the infusion of feces from a healthy donor to the GI tract of a recipient patient, in order to treat a specifi c disease associated with alteration of gut microbiota. There are still many unanswered questions regarding FMT, including donor selection and screening, standardized protocols, methodology, long-term safety, and regulatory issues.

Keywords

Fecal microbiota transplantation, Ülcerative colitis; Crohn disease, Irritable bowel syndrome

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