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Fekal Mikrobiyota Transplantasyonu (FMT)

Year 2017, - Mikrobiyota, 132 - 140, 15.11.2017

Abstract

Gaita nakli, Clostridium difficile infeksiyonu için önemli bir tedavi seçeneğidir. Gaita naklinin, bağırsak mikroflorasındaki değişiklikler ile ilgili diğer hastalıkların tedavisinde, rol oynayabileceği konusunda ümit verici bulgular tespit edilmiştir. Gaita nakli, bağırsak mikroflorasındaki değişiklikler ile ilgili spesifik hastalıkları tedavi etmek için, sağlıklı bir donörden alınan gaitanın, alıcı hastanın bağırsağına yerleştirilmesidir. Gaita nakli ile ilgili olarak, donör seçimi, donör taraması, yapılması gereken standart protokoller, metodlar ve uzun dönem güvenlik sonuçları dahil, cevaplanmamış bir çok soru hala vardır.

References

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Fecal Microbiota Transplantation (FMT)

Year 2017, - Mikrobiyota, 132 - 140, 15.11.2017

Abstract

Fecal microbiota transplantation (FMT) is an important therapeutic option for Clostridium diffi cile infection. Promising findings suggest that FMT may play a role also in the management of other disorders associated with the alteration of gut microbiota. Fecal microbiota transplantation (FMT) consists of the infusion of feces from a healthy donor to the GI tract of a recipient patient, in order to treat a specifi c disease associated with alteration of gut microbiota. There are still many unanswered questions regarding FMT, including donor selection and screening, standardized protocols, methodology, long-term safety, and regulatory issues.

References

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  • 4. Choi HH, Cho Y-S. Fecal Microbiota Transplantation: Current Applications, Effectiveness, and Future Perspectives. Clinical Endoscopy. 2016;49(3):257-265. doi:10.5946/ce.2015.117.
  • 5. Lee HJ, Choi JK, Ryu HS, et al. Therapeutic Modulation of Gut Microbiota in Functional Bowel Disorders. Journal of Neurogastroenterology and Motility. 2017;23(1):9-19. doi:10.5056/jnm16124.
  • 6. Borody TJ, Warren EF, Leis S, Surace R, Ashman O. Treatment of ulcerative colitis using fecal bacteriotherapy. J Clin Gastroenterol. 2003 Jul;37(1):42-7.
  • 7. Zhang F, Luo W, Shi Y, Fan Z, Ji G. Should we standardize the 1,700-year-old fecal microbiota transplantation? Am J Gastroenterol. 2012 Nov;107(11):1755; author reply p.1755-6. doi: 10.1038/ ajg.2012.251.
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  • 20. Choi HH, Cho Y-S. Fecal Microbiota Transplantation: Current Applications, Effectiveness, and Future Perspectives. Clinical Endoscopy. 2016;49(3):257-265. doi:10.5946/ce.2015.117.
  • 21. Evrensel A, Ceylan ME. Fecal Microbiota Transplantation and Its Usage in Neuropsychiatric Disorders. Clinical Psychopharmacology and Neuroscience. 2016;14(3):231-237. doi:10.9758/ cpn.2016.14.3.231.
  • 22. Drekonja D, Reich J, Gezahegn S, Greer N, Shaukat A, MacDonald R, Rutks I, Wilt TJ. Fecal Microbiota Transplantation for Clostridium diffi cile Infection: A Systematic Review. Ann Intern Med. 2015 May 5;162(9):630-8. doi: 10.7326/M14-2693. Review.
  • 23. Youngster I, Sauk J, Pindar C, et al. Fecal Microbiota Transplant for Relapsing Clostridium diffi cile Infection Using a Frozen Inoculum From Unrelated Donors: A Randomized, Open-Label, Controlled Pilot Study. Clinical Infectious Diseases: An Offi cial Publication of the Infectious Diseases Society of America. 2014;58(11):1515- 1522. doi:10.1093/cid/ciu135.
  • 24. Gough E, Shaikh H, Manges AR. Systematic review of intestinal microbiota transplantation (fecal bacteriotherapy) for recurrent Clostridium diffi cile infection. Clin Infect Dis. 2011 Nov;53(10):994- 1002. doi: 10.1093/cid/cir632. Review.
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There are 56 citations in total.

Details

Subjects Health Care Administration
Journal Section Review
Authors

Ahmet Uygun This is me

Publication Date November 15, 2017
Acceptance Date October 10, 2017
Published in Issue Year 2017 - Mikrobiyota

Cite

AMA Uygun A. Fecal Microbiota Transplantation (FMT). J Biotechnol and Strategic Health Res. November 2017;1:132-140.
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