BİR İLAÇ MONOGRAFI : MEROPENEM-VABORBAKTAM

Year 2018, Volume: 2 Issue: 1, 50 - 57, 30.04.2018

Hande Toptan , Mustafa Altındiş

Abstract

Meropenem
Vaborbaktam yakın zamanda Amerika’da kullanıma sunulmuş, iki faz III
çalışmasını başarıyla tamamlamış yeni bir β-laktamaz inhibitörlü karbapenem
kombinasyonudur. Kimyasal yapısı, etki mekanizması ve yan etki profili
bakımından diğer β-laktam antibiyotiklerle benzerlik taşımakla birlikte
antibakteriyel etkinliği açısından birçok üstünlüğe sahip olduğu belirtilmektedir.
Başta Klebsiella pneumoniae carbapenemase (KPC) olmak üzere belirli bazı
karbapenemaz türleri üzerinde etkili bulunması bu üstünlüğün en önemli
sebebidir. Karbapenem dirençli bakterilerle gerçekleştirilen TANGO II’de mümkün
olan en iyi tedavi ile meropenem-vaborbaktam alan hasta grupları kıyaslanmış,
meropenem-vaborbaktamın beklenenin üzerinde üstünlük sağlamasıyla çalışma
planlanandan önce sonlandırılmıştır. Günümüzde Meropenem – vaborbaktam
kombinasyonu dirençli Gram negatif bakterilerle meydana gelen komplike idrar
yolları enfeksiyonu / pyelonefrit için ruhsatlandırılmış; ventilatör ilişkili
pnömoni için Faz III çalışmaları devam etmektedir.

Keywords

Meropenem-vaborbaktam, Karpabepenem dirençli Enterobacteriaceae, KPC bakteriler, Metallo-beta-laktamazlar, Karbapenemazlar

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