SOLUNUM YOLU ÖRNEKLERİNDE İNSAN BOCAVİRUS'Ü SAPTANMASI

Year 2023, Volume: 7 Issue: 3, 206 - 212, 25.10.2023

Yeliz Tanrıverdi Çaycı , Elif Ateş , Demet Gür Vural , Kemal Bilgin , Asuman Bırıncı

https://doi.org/10.34084/bshr.1321392

Abstract

DETECTION OF HUMAN BOCAVIRUS IN RESPIRATORY TRACT SPECIMENS

Abstract

Objective: The aim of this study was to retrospectively examine the patients who presented with the complaints of respiratory tract infection and were found to have Human Bocavirus in the samples studied with the respiratory tract pathogens panel.
Methods: We retrospectively analyzed patients of all age groups who were diagnosed with Human Bocavirus by PCR in the respiratory tract pathogens panel between January 2019 and November 2022.
Results: Human Bocavirus was detected in 36 (3.64%) of 989 patients whose samples were studied with the respiratory tract pathogens panel. Fifteen of the patients (n:36) were under three years old. While Human Bocavirus was detected alone in 18 (50%) of the patients (n: 36), it was detected together with another factor in 18 (50%) patients.
Conclusion: Human Bocavirus can be detected alone and/or as co-, infection in children with acute respiratory tract infection. The cause-effect relationship between Human Bocavirus and respiratory tract infection is not clearly known.

Keywords

Human Bocavirus, Acute Respiratory Infection, Respiratory tract pathogens panel

References

• 1. Aktaş SY, Şahin F, Tekin D, Gerçeker D. Çocukluk Çağı Akut Solunum Yolları Enfeksiyonlarında Bocavirüs Saptanması. J Ankara Univ Fac Med. 2021;74(3):273-277. doi: 10.4274/atfm.galenos.2021.04935.
• 2. Özsürekci Y, Aykaç K, Başaranoğlu S ve ark. Çocuklarda bokavirus enfeksiyonları: Hacettepe Üniversitesi deneyimi. Cocuk Sagligi ve Hastalik. Derg. 2016;59(3):120-125.
• 3. Arslan A, Çiçek C, Saz EU, Gülen F, Karakuş HS. Viral Solunum Yolu Enfeksiyonlarının Tanısında Bir Multipleks PCR Yönteminin Performansının Değerlendirilmesi. Türk Mikrobiyol Cem Derg. 2016,46(4):159-164. doi:10.5222/TMCD.2016.159.
• 4. Guido M, Tumolo MR, Verri T, et al. Human bocavirus: Current knowledge and future challenges. World J Gastroenterol. 2016;22(39):8684-8697. doi: 10.3748/wjg.v22.i39.8684.
• 5. Falahi S, Sayyadi H, Abdoli A, Kenarkoohi A, Mohammadi S. The prevalence of human bocavirus in <2-year-old children with acute bronchiolitis. New Microbes and New Infect. 2020; 37: 100736. doi: 10.1016/j.nmni.2020.100736.
• 6. Verbeke V, Reynders M, Floré K, et al. Human bocavirus infection in Belgian children with respiratory tract disease. Arch Virol. 2019;164(12):2919-2930. doi: 10.1007/s00705-019-04396-6.
• 7. Peltola V, Söderlund-Venermo M, Jartti T. Human Bocavirus Infections. J Pediatr Infect Dis. 2013;32(2):178-179. doi: 10.1097/INF.0b013e31827fef67.
• 8. Bagasi AA, Howson-Wells HC, Clark G, et al. Human Bocavirus infection and respiratory tract disease identified in a UK patient cohort. J Clin Virol. 2020; 129:104453. doi: 10.1016/j.jcv.2020.104453.
• 9. Martin ET, Fairchok MP, Kuypers J, et al. Frequent and Prolonged Shedding of Bocavirus in Young Children Attending Daycare. J Infect Dis. 2010;201(11):1625–32. doi: 10.1086/652405. 10. Allander T, Tammi MT, Eriksson M, Bjerkner A, Tiveljung-Lindell A, Andersson B. Cloning of a human parvovirus by molecular screening of respiratory tract samples. Proc Natl Acad Sci USA. 2005;102(36):12891-6. doi: 10.1073/pnas.0504666102.
• 11. Pavia AT. Viral infections of the lower respiratory tract: old viruses, new viruses, and the role of diagnosis. Clin Infect Dis. 2011;52(4):284–89. doi: 10.1093/cid/cir043.
• 12. Chow BDW, Esper FP. The Human Bocaviruses: A Review and Discussion of Their Role in Infection. Clin Lab Med. 2009,29(4):695–713. doi: 10.1016/j.cll.2009.07.010.
• 13. Jartti T, Hedman K, Jartti L, Ruuskanen O, Allander T, Söderlund-Venermo M. Human bocavirus-the first 5 years. Rev Med Virol. 2012;22(1):46-64. doi: 10.1002/rmv.720.
• 14. Joseph OO, Adeniji JA, Faneye OA. Human Bocavirus infection among children with respiratory tract infection in Ibadan, Nigeria. Access Microbiol. 2022;4(5):acmi000356. doi: 10.1099/acmi.0.000356
• 15. Petrarca L, Nenna R, Frassanito A, et al. Human bocavirus in children hospitalized for acute respiratory tract infection in Rome. World J Pediatr. 2020;16(3):293-298. doi: 10.1007/s12519-019-00324-5.
• 16. Silva PE, Figueiredo CA, Luchs A, et al. Human bocavirus in hospitalized children under 5 years with acute respiratory infection, São Paulo, Brazil, 2010. Arch Virol 2018; 163(5):1325-1330. doi: 10.1007/s00705-017-3694-5.
• 17. Madi NM, Al-Adwani A. Human bocavirus (HBoV) in Kuwait: molecular epidemiology and clinical outcome of the virus among patients with respiratory diseases. J Med Microbiol. 2020;69(7):1005-1012. doi: 10.1099/jmm.0.001219.
• 18. Ljubin-Sternak S, Slović A, Mijač M, et al. Prevalence and Molecular Characterization of Human Bocavirus Detected in Croatian Children with Respiratory Infection. Viruses. 2021;13(9):1728. doi: 10.3390/v13091728.
• 19. Uyar M, Kuyucu N, Tezcan S, Aslan G, Tasdelen B. Determination of the frequency of human bocavirus and other respiratory viruses among 0-2 years age group children diagnosed as acute bronchiolitis. Mikrobiyol Bul. 2014;48(2):242-258. doi: 10.5578/mb.7575.
• 20. Kesebir D, Vazquez M, Weibel C, et al. Human bocavirus infection in young children in the United States: molecular epidemiological profile and clinical characteristics of a newly emerging respiratory virus. J Infect Dis. 2006;194(9):1276-1282. doi: 10.1086/508213.
• 21. Fry AM, Lu X, Chittaganpitch M, et al. Human Bocavirus: A Novel Parvovirus Epidemiologically Associated with Pneumonia Requiring Hospitalization in Thailand. J Infect Dis. 2007;195(7):1038-45. doi: 10.1086/512163.
• 22. Wagner JC, Pyles RB, Miller AL, Nokso-Koivisto J, Loeffelholz MJ, Chonmaitree T. Determining Persistence of Bocavirus DNA in the Respiratory Tract of Children by Pyrosequencing. Pediatr Infect Dis J. 2016;35(5):471-6. doi: 10.1097/INF.0000000000001058.
• 23. Ricour C, Goubau P. Human Bocavırus, A Newly Dıscovered Parvovırus of The Respıratory Tract. Acta Clin Belg. 2008;63(5):329-334. doi: 10.1179/acb.2008.064.
• 24. Schildgen O, Müller A, Allander T, et al. Human bocavirus: passenger or pathogen in acute respiratory tract infections?. Clin Microbiol Rev. 2008;21(2):291-304. doi: 10.1128/CMR.00030-07.