ALKOL KULLANIM BOZUKLUĞUNUN GENETİĞİ

Hasan Kaya; Özlem Bolat  Kaya; Nesrin Dilbaz

doi:10.5455/car.20170705081115

Review

ALKOL KULLANIM BOZUKLUĞUNUN GENETİĞİ

Year 2017, , 33 - 46, 07.03.2017

Hasan Kaya Özlem Bolat Kaya Nesrin Dilbaz

https://doi.org/10.5455/car.20170705081115

Abstract

Giriş: Alkol kullanım bozukluğu (AKB); olumsuz duygusal, fiziksel ve sosyal sonuçlara yol açan zararlı içme paternleriyle karakterize olan kronik psikiyatrik bir bozukluktur. İkiz, aile ve evlat edinme çalışmaları genetik faktörlerin AKB patogenezinde kritik rol oynadığını tutarlı bir şekilde göstermiştir. AKB’ye yatkınlık üzerinde etkili genleri belirlemeyi amaçlayan birçok çalışma yapılmıştır. Bu derlemede, ikiz çalışmaları, bağlantı çalışmaları, aday gen çalışmaları ve genom boyu ilişki çalışmalarını (GWAS) içeren, AKB ile ilgili yapılmış genetik araştırmalar gözden geçirilmiştir. AKB’nin çok
sayıda gendeki varyasyonlarla gelişme riski belirlenen kompleks bir genetik bozukluk olduğuna dair kanıtlar giderek artmaktadır. Bu genlerden bazıları belirlenmiştir; alkol metabolizmasında rol oynayan ADH1B ve ALDH2 bunlar içinde en güçlü kanıtlara sahip olunan genlerdir. GABRA2, DRD2, OPRM1, MAOA VE PECR genlerini de içeren bazı genlerin varyantaları üzerindeki çalışmalara
devam edilmektedir. Daha fazla varyant analiz edildikçe ve yeni meta-analizler yayınlandıkça AKB riskini etkileyen birçok gen ve yolağın bir arada değerlendirildiği bir bakış açısına sahip olmak mümkün olacaktır.

Keywords

Alkol kullanım bozukluğu, tek nükleotid polimorfizmleri, genom boyu ilişki çalışmaları

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Year 2017, , 33 - 46, 07.03.2017

Hasan Kaya Özlem Bolat Kaya Nesrin Dilbaz

https://doi.org/10.5455/car.20170705081115

Abstract

References

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2. Heath AC, Bucholz K, Madden P, Dinwiddie S, Slutske W, Bierut L, et al. Genetic and environmental contributions to alcohol dependence risk in a national twin sample: consistency of findings in women and men. Psychological medicine. 1997;27(06):1381-96.
3. Edenberg HJ. Genetics of Alcohol Use Disorders. In Biological Research on Addiction. Elsevier Inc.2013. p. 499-508.
4. Reich T, Edenberg HJ, Goate A, Williams JT, Rice JP, Van Eerdewegh P, et al. Genome-wide search for genes affecting the risk for alcohol dependence. Am J Med Genet. 1998;81(3):207-15.
5. Long JC, Knowler WC, Hanson RL, Robin RW, Urbanek M, Moore E, et al. Evidence for genetic linkage to alcohol dependence on chromosomes 4 and 11 from an autosome-wide scan in an American Indian population. Am J Med Genet. 1998;81(3):216-21.
6. Edenberg HJ, Dick DM, Xuei X, Tian H, Almasy L, Bauer LO, et al. Variations in GABRA2, encoding the alpha 2 subunit of the GABA(A) receptor, are associated with alcohol dependence and with brain oscillations. Am J Hum Genet. 2004;74(4):705-14.
7. Thomasson HR, Edenberg HJ, Crabb DW, Mai XL, Jerome RE, Li TK, et al. Alcohol and aldehyde dehydrogenase genotypes and alcoholism in Chinese men. Am J Hum Genet. 1991;48(4):677-81.
8. Li D, Zhao H, Gelernter J. Strong protective effect of the aldehyde dehydrogenase gene (ALDH2) 504lys (*2) allele against alcoholism and alcohol-induced medical diseases in Asians. Hum Genet. 2012;131(5):725- 37.
9. Bierut LJ, Goate AM, Breslau N, Johnson EO, Bertelsen S, Fox L, et al. ADH1B is associated with alcohol dependence and alcohol consumption in populations of European and African ancestry. Mol Psychiatry. 2012;17(4):445-50.
10. Edenberg HJ, Xuei X, Chen HJ, Tian H, Wetherill LF, Dick DM, et al. Association of alcohol dehydrogenase genes with alcohol dependence: a comprehensive analysis. Hum Mol Genet. 2006;15(9):1539-49.
11. Hurley TD, Edenberg HJ, Li T-K. Pharmacogenomics of Alcoholism. Pharmacogenomics: Wiley-VCH Verlag GmbH & Co. KGaA; 2003. p. 417- 41.
12. Crabb DW, Edenberg HJ, Bosron WF, Li TK. Genotypes for aldehyde dehydrogenase deficiency and alcohol sensitivity. The inactive ALDH2(2) allele is dominant. J Clin Invest. 1989;83(1):314-6.
13. Higuchi S. Polymorphisms of ethanol metabolizing enzyme genes and alcoholism. Alcohol Alcohol Suppl. 1994;2:29-34.
14. Neville MJ, Johnstone EC, Walton RT. Identification and characterization of ANKK1: a novel kinase gene closely linked to DRD2 on chromosome band 11q23.1. Hum Mutat. 2004;23(6):540-5.
15. Smith L, Watson M, Gates S, Ball D, Foxcroft D. Meta-analysis of the association of the Taq1A polymorphism with the risk of alcohol dependency: a HuGE gene-disease association review. Am J Epidemiol. 2008;167(2):125-38.
16. Wang F, Simen A, Arias A, Lu QW, Zhang H. A large-scale meta-analysis of the association between the ANKK1/DRD2 Taq1A polymorphism and alcohol dependence. Hum Genet. 2013;132(3):347-58.
17. McIntyre JC, Titlow WB, McClintock TS. Axon growth and guidance genes identify nascent, immature, and mature olfactory sensory neurons. J Neurosci Res. 2010;88(15):3243-56.
18. Katoh M. Identification and characterization of TPARM gene in silico. Int J Oncol. 2003;23(4):1213-7.
19. Huang W, Payne TJ, Ma JZ, Beuten J, Dupont RT, Inohara N, et al. Significant association of ANKK1 and detection of a functional polymorphism with nicotine dependence in an African-American sample. Neuropsychopharmacology. 2009;34(2):319-30.
20. Edenberg HJ. Biological Research on Addiction: Chapter 49. Genetics of Alcohol Use Disorders: Elsevier Inc. Chapters; 2013.
21. Hutchison KE, McGeary J, Smolen A, Bryan A, Swift RM. The DRD4 VNTR polymorphism moderates craving after alcohol consumption. Health Psychol. 2002;21(2):139-46.
22.Vaughn MG, Beaver KM, DeLisi M, Howard MO, Perron BE. Dopamine D4 receptor gene exon III polymorphism associated with binge drinking attitudinal phenotype. Alcohol. 2009;43(3):179-84.
23.Laucht M, Becker K, Blomeyer D, Schmidt MH. Novelty seeking involved in mediating the association between the dopamine D4 receptor gene exon III polymorphism and heavy drinking in male adolescents: results from a high-risk community sample. Biol Psychiatry. 2007;61(1):87-92.
24.Tiihonen J, Hallikainen T, Lachman H, Saito T, Volavka J, Kauhanen J, et al. Association between the functional variant of the catechol-O-methyltransferase (COMT) gene and type 1 alcoholism. Mol Psychiatry. 1999;4(3):286-9.
25.Wang T, Franke P, Neidt H, Cichon S, Knapp M, Lichtermann D, et al. Association study of the low-activity allele of catechol-O-methyltransferase and alcoholism using a family-based approach. Mol Psychiatry. 2001;6(1):109-11.
26.Enoch MA, Waheed JF, Harris CR, Albaugh B, Goldman D. Sex differences in the influence of COMT Val158Met on alcoholism and smoking in plains American Indians. Alcohol Clin Exp Res. 2006;30(3):399-406.
27.Foroud T, Wetherill LF, Dick DM, Hesselbrock V, Nurnberger JI, Jr., Kramer J, et al. Lack of association of alcohol dependence and habitual smoking with catechol-O-methyltransferase. Alcohol Clin Exp Res. 2007;31(11):1773-9.
28.van der Zwaluw CS, Engels RC, Buitelaar J, Verkes RJ, Franke B, Scholte RH. Polymorphisms in the dopamine transporter gene (SLC6A3/DAT1) and alcohol dependence in humans: a systematic review. Pharmacogenomics. 2009;10(5):853-66.
29.Schmidt LG, Harms H, Kuhn S, Rommelspacher H, Sander T. Modification of alcohol withdrawal by the A9 allele of the dopamine transporter gene. Am J Psychiatry. 1998;155(4):474-8.
30.Kimura M, Higuchi S. Genetics of alcohol dependence. Psychiatry Clin Neurosci. 2011;65(3):213-25.
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Details

Primary Language	Turkish
Subjects	Psychology, Subtance Abuse
Journal Section	Review Article
Authors	Hasan Kaya This is me Özlem Bolat Kaya This is me Nesrin Dilbaz This is me
Publication Date	March 7, 2017
Published in Issue	Year 2017

Cite

APA	Kaya, H., Bolat Kaya, Ö., & Dilbaz, N. (2017). ALKOL KULLANIM BOZUKLUĞUNUN GENETİĞİ. Current Addiction Research, 1(1), 33-46. https://doi.org/10.5455/car.20170705081115
AMA	Kaya H, Bolat Kaya Ö, Dilbaz N. ALKOL KULLANIM BOZUKLUĞUNUN GENETİĞİ. Current Addiction Research. March 2017;1(1):33-46. doi:10.5455/car.20170705081115
Chicago	Kaya, Hasan, Özlem Bolat Kaya, and Nesrin Dilbaz. “ALKOL KULLANIM BOZUKLUĞUNUN GENETİĞİ”. Current Addiction Research 1, no. 1 (March 2017): 33-46. https://doi.org/10.5455/car.20170705081115.
EndNote	Kaya H, Bolat Kaya Ö, Dilbaz N (March 1, 2017) ALKOL KULLANIM BOZUKLUĞUNUN GENETİĞİ. Current Addiction Research 1 1 33–46.
IEEE	H. Kaya, Ö. Bolat Kaya, and N. Dilbaz, “ALKOL KULLANIM BOZUKLUĞUNUN GENETİĞİ”, Current Addiction Research, vol. 1, no. 1, pp. 33–46, 2017, doi: 10.5455/car.20170705081115.
ISNAD	Kaya, Hasan et al. “ALKOL KULLANIM BOZUKLUĞUNUN GENETİĞİ”. Current Addiction Research 1/1 (March 2017), 33-46. https://doi.org/10.5455/car.20170705081115.
JAMA	Kaya H, Bolat Kaya Ö, Dilbaz N. ALKOL KULLANIM BOZUKLUĞUNUN GENETİĞİ. Current Addiction Research. 2017;1:33–46.
MLA	Kaya, Hasan et al. “ALKOL KULLANIM BOZUKLUĞUNUN GENETİĞİ”. Current Addiction Research, vol. 1, no. 1, 2017, pp. 33-46, doi:10.5455/car.20170705081115.
Vancouver	Kaya H, Bolat Kaya Ö, Dilbaz N. ALKOL KULLANIM BOZUKLUĞUNUN GENETİĞİ. Current Addiction Research. 2017;1(1):33-46.

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