ALKOL KULLANIM BOZUKLUĞUNUN GENETİĞİ

Hasan Kaya; Özlem Bolat Kaya; Nesrin Dilbaz

doi:10.5455/car.20170705081115

ALKOL KULLANIM BOZUKLUĞUNUN GENETİĞİ

Öz

Giriş: Alkol kullanım bozukluğu (AKB); olumsuz duygusal, fiziksel ve sosyal sonuçlara yol açan zararlı içme paternleriyle karakterize olan kronik psikiyatrik bir bozukluktur. İkiz, aile ve evlat edinme çalışmaları genetik faktörlerin AKB patogenezinde kritik rol oynadığını tutarlı bir şekilde göstermiştir. AKB’ye yatkınlık üzerinde etkili genleri belirlemeyi amaçlayan birçok çalışma yapılmıştır. Bu derlemede, ikiz çalışmaları, bağlantı çalışmaları, aday gen çalışmaları ve genom boyu ilişki çalışmalarını (GWAS) içeren, AKB ile ilgili yapılmış genetik araştırmalar gözden geçirilmiştir. AKB’nin çok sayıda gendeki varyasyonlarla gelişme riski belirlenen kompleks bir genetik bozukluk olduğuna dair kanıtlar giderek artmaktadır. Bu genlerden bazıları belirlenmiştir; alkol metabolizmasında rol oynayan ADH1B ve ALDH2 bunlar içinde en güçlü kanıtlara sahip olunan genlerdir. GABRA2, DRD2, OPRM1, MAOA VE PECR genlerini de içeren bazı genlerin varyantaları üzerindeki çalışmalara devam edilmektedir. Daha fazla varyant analiz edildikçe ve yeni meta-analizler yayınlandıkça AKB riskini etkileyen birçok gen ve yolağın bir arada değerlendirildiği bir bakış açısına sahip olmak mümkün olacaktır.

Anahtar Kelimeler

Kaynakça

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Ayrıntılar

Birincil Dil

Türkçe

Konular

Psikoloji, Madde Bağımlılığı

Bölüm

Derleme

Yazarlar

Hasan Kaya Bu kişi benim
Türkiye

Özlem Bolat Kaya Bu kişi benim
Türkiye

Nesrin Dilbaz Bu kişi benim
Türkiye

Yayımlanma Tarihi

7 Mart 2017

Gönderilme Tarihi

17 Ocak 2017

Kabul Tarihi

-

Yayımlandığı Sayı

Yıl 2017 Cilt: 1 Sayı: 1

DOI

https://doi.org/10.5455/car.20170705081115

IZ

https://izlik.org/JA62KJ27SM

Kaynak Göster

RIS / Bibtex

APA

Kaya, H., Bolat Kaya, Ö., & Dilbaz, N. (2017). ALKOL KULLANIM BOZUKLUĞUNUN GENETİĞİ. Current Addiction Research, 1(1), 33-46. https://doi.org/10.5455/car.20170705081115

AMA

1.Kaya H, Bolat Kaya Ö, Dilbaz N. ALKOL KULLANIM BOZUKLUĞUNUN GENETİĞİ. Current Addiction Research. 2017;1(1):33-46. doi:10.5455/car.20170705081115

Chicago

Kaya, Hasan, Özlem Bolat Kaya, ve Nesrin Dilbaz. 2017. “ALKOL KULLANIM BOZUKLUĞUNUN GENETİĞİ”. Current Addiction Research 1 (1): 33-46. https://doi.org/10.5455/car.20170705081115.

EndNote

Kaya H, Bolat Kaya Ö, Dilbaz N (01 Mart 2017) ALKOL KULLANIM BOZUKLUĞUNUN GENETİĞİ. Current Addiction Research 1 1 33–46.

IEEE

[1]H. Kaya, Ö. Bolat Kaya, ve N. Dilbaz, “ALKOL KULLANIM BOZUKLUĞUNUN GENETİĞİ”, Current Addiction Research, c. 1, sy 1, ss. 33–46, Mar. 2017, doi: 10.5455/car.20170705081115.

ISNAD

Kaya, Hasan - Bolat Kaya, Özlem - Dilbaz, Nesrin. “ALKOL KULLANIM BOZUKLUĞUNUN GENETİĞİ”. Current Addiction Research 1/1 (01 Mart 2017): 33-46. https://doi.org/10.5455/car.20170705081115.

JAMA

1.Kaya H, Bolat Kaya Ö, Dilbaz N. ALKOL KULLANIM BOZUKLUĞUNUN GENETİĞİ. Current Addiction Research. 2017;1:33–46.

MLA

Kaya, Hasan, vd. “ALKOL KULLANIM BOZUKLUĞUNUN GENETİĞİ”. Current Addiction Research, c. 1, sy 1, Mart 2017, ss. 33-46, doi:10.5455/car.20170705081115.

Vancouver

1.Hasan Kaya, Özlem Bolat Kaya, Nesrin Dilbaz. ALKOL KULLANIM BOZUKLUĞUNUN GENETİĞİ. Current Addiction Research. 01 Mart 2017;1(1):33-46. doi:10.5455/car.20170705081115