Predictive Value of Mean Platelet Volume and Platelet Levels for Preeclampsia

Öz

Objective: Preeclampsia is a pregnancy-specific disease with hypertension, proteinuria, and/or organ damage. This study aimed to investigate whether preeclampsia is predictable or not based on some hematological parameters at primary care units step where routine follow-ups are made during the pregnancy. Materials and methods: In this retrospective study, 58 pregnant women with preeclampsia and 116 healthy pregnant women were included. Two different hemogram results belonging to the time of diagnosis and 2-6 weeks before diagnosis in the preeclampsia group; and two different hemogram results belonging to the time of delivery and 2-6 weeks before delivery for the control group were included in the study. Results: It was determined that MPV levels were higher; platelet count, NLR, and PLR levels were lower in the second hemogram results compared with the first hemogram results of the preeclampsia group. The ROC analysis result, it was revealed that the sensitivity and specificity of MPV for predicting preeclampsia were 75,9% and 33,3%, respectively, when the cut-off value of MPV was accepted as 8,95 (fL). Conclusion: When we compared the results of our study with the literature, it was evaluated that MPV, NLR, and PLR data could be used for the prediction of preeclampsia patients. It has been required for a long duration of studies that need a large number of patients to use the tendency in an increase of MPV and the decrease of NLR and PLR for prediction of preeclampsia.

Anahtar Kelimeler

• Hypertension
• Mean Platelet Volume
• Preeclampsia

Preeklampsi Olgularında Ortalama Trombosit Hacmi ve Trombosit Düzeylerinin İncelenmesi

Öz

Giriş ve Amaç: Preeklampsi; hipertansiyon, proteinüri ve/veya organ hasarı ile seyreden gebeliğe özgü bir hastalıktır. Bu çalışmada, gebelikte rutin takiplerin yapıldığı birinci basamakta bazı hematolojik parametrelere göre preeklampsinin öngörülebilir olup olmadığının araştırılması amaçlanmıştır. Gereç ve Yöntemler: Bu retrospektif çalışmaya 58 preeklampsili gebe ve 116 sağlıklı gebe dahil edildi. Preeklampsi grubunda tanı anına ve tanıdan 2-6 hafta öncesine ait iki farklı hemogram sonucu; kontrol grubu için doğum zamanı ve doğumdan 2-6 hafta öncesine ait iki farklı hemogram sonucu çalışmaya dahil edildi. Bulgular: Preeklampsi grubunun ikinci hemogram sonuçlarında trombosit sayısı, NLR ve PLR düzeyleri ilk hemogram sonuçlarına göre daha düşük, MPV düzeyleri daha yüksek olarak bulundu. ROC analizi sonucu, MPV’nin 8.95 (fL) kabul edildiği cut-off değerinde preeklampsiyi öngörmedeki duyarlılığı %75,9 ve özgüllüğü %33,3 olarak saptandı. Sonuç: Çalışmamızın sonuçlarını literatürle karşılaştırdığımızda MPV, NLR ve PLR verilerinin preeklampsi tanılı hastaları öngörmede kullanılabilir olduğu değerlendirildi. MPV’de yükselme, NLR ve PLR’de düşme eğiliminin preeklampsiyi öngörmede kullanılabilmesi için daha fazla hasta sayılı ve uzun süreli çalışmalara ihtiyaç duyulmaktadır.

Anahtar Kelimeler

• Hipertansiyon
• Ortalama Trombosit Hacmi
• Preeklampsi

Kaynakça

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