Nf-Kappa B Signaling Pathway and Potential Therapeutic Approaches in Cancer

Abstract

Intracellular pathways involved in cell survival regulate neuronal physiology during development and neurodegenerative disorders. One of the pathways that appears to play an important role in these processes is the nuclear factor-κB signaling pathway. The activity of this pathway leads to nuclear translocation of NF-κB transcription factors and regulation of anti-apoptotic gene expression. Different stimuli can contribute to the translocation of certain dimers of NF-κB transcription factors by activating the pathway through different intracellular cascades (canonical, non-canonical and atypical), and each of these dimers can regulate the transcription of different genes. Recent studies have shown that activation of this pathway regulates opposite responses such as cell survival or neuronal degeneration. These obvious contradictory effects are dependent on conditions such as pathway stimulation, source of cells or cellular context.

Keywords

• NF-κB
• NF-κB Signal Patchway
• Cancer

Nf-Kappa B Sinyal Yolu ve Kanserde Potansiyel Terapotik Yaklaşımlar

Abstract

Hücrenin hayatta kalmasıyla ilgili hücre içi yollar, gelişim ve nörodejeneratif bozukluklar sırasında nöronal fizyolojiyi düzenler. Bu süreçlerde önemli bir rolle ortaya çıkan yollardan biri Nüklear Faktör-κB (NF-κB) sinyal yolağıdır. Bu yolağın aktivitesi, NF-κB transkripsiyon faktörlerinin nüklear translokasyonuna ve anti-apoptotik gen ekspresyonunun düzenlenmesine yol açar. Farklı uyaranlar, farklı hücre içi kademeler (kanonik, kanonik olmayan ve atipik) yoluyla bu yolağı aktive ederek NF-κB transkripsiyon faktörlerinin belirli dimerlerinin translokasyonuna katkıda bulunabilir ve bu dimerlerden her biri farklı genlerin transkripsiyonunu düzenleyebilir. Son çalışmalar, bu yolun aktivasyonunun, hücrenin hayatta kalması veya nöronal dejenerasyon gibi zıt yanıtları düzenlediğini göstermiştir. Bu bariz çelişkili etkiler, yolak uyarısı, hücrelerin kaynağı veya hücresel bağlam gibi koşullara bağlıdır.

Keywords

• NF-κB
• NF-κB sinyal yolu
• Kanser

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