The Relationship Between Obstructive Coronary Artery Disease and Serum 25-OH Vitamin D, Fetuin-A, Matrix Gla Protein, and ADMA Levels

Abstract

Objective: In this study, the relationship between the markers of 25OH-vitamin D, Matrix Gla Protein (MGP), Fetuin-A, Asymmetric Dimethyl Arginine (ADMA), which are suggested to play a role in the etiology of atherosclerosis, and coronary artery disease was investigated. Materials and Methods: For this purpose, a total of 80 patients, including 40 patients with normal coronary artery and 40 patients with 70% or more stenosis in at least one coronary artery, who underwent coronary angiography with a preliminary diagnosis of coronary artery disease, were included in the study. Results: While blood MGP levels were observed to be significantly higher in the coronary artery disease group compared to the control group (2082.79±329.75 pg/ml and 1853.42±285.82 pg/ml, p=0.001, respectively), Fetuin-A levels in the control group group was significantly lower than the coronary artery disease group (60.54±28.61 ng/ml and 78.61±20.45 ng/ml, respectively, p=0.002). Although 25OH-vitamin D levels were observed at low levels in 85% of the patients in both groups, no statistically significant difference was found between the two groups (20.27±12.65 ng/ml and 20.64±7.32 ng/ml, respectively). ml, p=0.875). When blood ADMA levels were examined, no statistically significant difference was observed between the groups (group 1; 0.099±0.053 umol/l and group 2; 0.089±0.051 umol/l, p>0.05). As a result; While no significant relationship was found between 25OH-vitamin D and ADMA values and coronary artery disease, it was observed that MGP and Fetuin-A could be markers for occlusive coronary artery disease. Conclusion: In our study, it was observed that MGP and Fetuin-A biomarkers were guiding in the diagnosis of occlusive coronary artery disease. In the light of these findings, new studies with a similar background and larger populations are needed to evaluate the use of MGP and Fetuin-A levels in the diagnosis of coronary artery disease.

Keywords

• 25OH-vitamin D
• Fetuin-A
• MGP
• ADMA
• coronary artery disease

Project Number

2012-091

Obstrüktif Koroner Arter Hastalığı İle Serum 25-OH Vitamin D, Fetuin-A, Matrix Gla Protein Ve ADMA Düzeyleri Arasındaki İlişki

Abstract

Giriş ve Amaç: Bu çalışmada ateroskleroz etyolojisinde rol oynadığı ileri sürülen 25OH-vitamin D, Matrix Gla Protein (MGP), Fetuin-A, Asimetrik Dimetil Arjinin (ADMA) belirteçleri ile koroner arter hastalığı arasındaki ilişki araştırıldı. Gereç ve Yöntemler: Bu amaçla çalışmaya koroner arter hastalığı ön tanısı ile koroner anjiyografi işlemi uygulanmış olan ve normal koroner arter saptanan 40 olgu ile, en az bir koroner arterinde %70 ve üzerinde darlık saptanan 40 olgu olmak üzere toplam 80 olgu dahil edildi. Bulgular: Kan MGP düzeyleri koroner arter hastalığı olan grupta kontrol grubuna kıyasla anlamlı olarak yüksek olarak gözlenirken (sırasıyla 2082,79±329,75 pg/ml ve 1853,42±285,82 pg/ml, p=0,001), Fetuin-A düzeylerinin kontrol grubunda, koroner arter hastalığı grubuna kıyasla anlamlı derecede düşük olduğu gözlendi (sırasıyla 60,54±28,61 ng/ml ve 78,61±20,45 ng/ml, p=0,002). Her iki gruptaki hastaların %85’inde 25OH-vitamin D seviyeleri düşük düzeylerde izlenmekle beraber, her iki grup arasında istatistiksel olarak anlamlı olarak fark saptanmadı (sırasıyla 20,27±12,65 ng/ml ve 20,64±7,32 ng/ml, p=0,875). Kan ADMA seviyeleri incelendiğinde ise yine gruplar arasında istatistiksel olarak anlamlı bir fark gözlenmedi (grup 1; 0,099±0,053 umol/l ve grup 2; 0,089±0,051 umol/l, p>0,05). Sonuç olarak; 25OH-vitamin D ve ADMA değerleri ile koroner arter hastalığı arasında anlamlı bir ilişki saptanmazken, MGP ve Fetuin-A'nın tıkayıcı koroner arter hastalığında belirteç olabileceği gözlendi. Sonuç: Bizim çalışmamızda tıkayıcı koroner arter hastalığı tanısında MGP ve Fetuin-A biyobelirteçlerinin yol gösterici olduğu gözlenmiştir. Bu bulgular ışığında MGP ve Fetuin-A düzeylerinin koroner arter hastalığı tanısında kullanımının değerlendirilmesi için benzer altyapılı ve daha geniş popülasyonlarla yapılacak yeni çalışmalara ihtiyaç vardır.

Keywords

• Koroner Arter Hastalığı
• 25OH-vitamin D
• Fetuin-A
• MGP
• ADMA
• Koroner Arter Hastalığı, 25OH-vitamin D, Fetuin-A, MGP, ADMA

Supporting Institution

T.C. CELAL BAYAR ÜNİVERSİTESİ BİLİMSEL ARAŞTIRMA PROJELERİ KOORDİNATÖRLÜĞÜ

Project Number

2012-091

Thanks

Bu çalışmanın gerçekleştirilmesinde proje desteği sağlayan Celal Bayar Üniversitesi Bilimsel Araştırmalar Komisyonuna ve değerli çalışanlarına çok teşekkür ederiz.

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