Evaluation of the Effect of Treatment with Angiotensin Type 1 Receptor Blockers in Hypertensive Patients by Exercise Tissue Doppler Echocardiographic Parameters

Abstract

Objective: The current study aims to examine the effect of Telmisartan treatment on functional and structural cardiac change at rest and during exercise in hypertensive (HT) patients using conventional echocardiography (ECHO) and tissue Doppler ultrasound (US). Materials and Methods: A total of 26 patients (16 female, 10 male with a mean age of 51.9±8.54) with a diagnosis of essential HT were included in the study. Arterial blood pressure measurements, conventional ECHO and tissue Doppler US recordings during rest and stress (cycling ergometry) periods were taken before the treatment and after 6 months of follow-up. Results: The mean blood pressure of the patients decreased from 109.8±4.6 mmHg to 92.2±6.4 mmHg (p<0.05). After telmisartan treatment, it was determined that there was a significant improvement in diastolic function and myocardial performance index (MPI) values measured by tissue Doppler during rest and stress with telmisartan treatment (p<0.05). Conclusion: Telmisartan monotherapy provides blood pressure control in patients with essential HT and enables significant improvements in left ventricular hypertrophy, cardiac functions at rest and during exercise, and structural changes.

Keywords

• Hypertension
• angiotensin receptor blocker
• tissue Doppler imaging

Hipertansif Hastalarda Angiotensin Tip 1 Resptör Blokörleri ile Tedavi Etkisinin Egzersiz Doku Doppler Ekokardiyografik Parametrelerle Değerlendirilmesi

Abstract

Giriş ve Amaç: Bu çalışmada hipertansif (HT) hastalarda Telmisartan tedavisinin altı aylık dönemde dinlenim ve egzersiz esnasında fonksiyonel ve yapısal kardiyak değişime etkisini konvansiyonel ekokardiyografi (EKO) ve doku Doppler ultason (US) kullanarak incelemeyi amaçladık. Gereç ve Yöntemler: Çalışmaya yaş ortalaması 51.9±8.54 olan esansiyel HT tanılı 26 hasta (16 kadın, 10 erkek) alındı. Hastalara Telmisartan 80 mg/gün tedavisi verildi. Tedavi öncesinde ve 6 aylık izlemin ardından arteriyel kan basıncı ölçümleri ile dinlenim ve stres (bisiklet ergometrisi) esnasında konvansiyonel EKO ve doku Doppler US kayıtları alındı. Bulgular: Hastaların ortalama kan basıncı 109,8±4,6 mmHg’den 92,2±6,4 mmHg’ye geriledi (p<0.05). Telmisartan tedavisi sonrasında dinlenim ve stres esnasında da doku Doppler ile ölçülen diyastolik fonksiyon belirteçlerinde ve miyokard performans indeks (MPI) değerlerinde telmisartan tedavisiyle anlamlı düzelme olduğu saptandı (p<0.05). Sonuç: Telmisartan monoterapisi esansiyel HT tanılı hastalarda kan basıncı kontrolünü sağlamakta, sol ventrikül hipertrofisini, dinlenme ve egzersiz sırasındaki kardiyak fonksiyonları ve yapısal değişikliklerde anlamlı düzelme sağlamaktadır.

Keywords

• Hipertansiyon
• angiotensin reseptör blokeri
• doku Doppler görüntüleme

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